Abstract
Microvesicles in endocrine cells are the morphological and functional equivalent of neuronal synaptic vesicles. Microvesicles accumulate various neurotransmitters through a transmitter-specific vesicular transporter energized by vacuolar H+-ATPase. We found that mammalian pinealocytes, endocrine cells that synthesize and secrete melatonin, accumulate L-glutamate in their microvesicles and secrete it through exocytosis. Pinealocytes use L-glutamate as either a paracrine- or autocrine-like chemical transmitter in a receptor-mediated manner, resulting in inhibition of melatonin synthesis. In this article, we briefly describe the overall features of the microvesicle-mediated signal-transduction mechanism in the pineal gland and discuss the important role of acidic organelles in a novel regulatory mechanism for hormonal synthesis and secretion.
| Original language | English |
|---|---|
| Pages (from-to) | 117-125 |
| Number of pages | 9 |
| Journal | Journal of Experimental Biology |
| Volume | 203 |
| Issue number | 1 |
| Publication status | Published - Jan 2000 |
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Keywords
- Autocrine
- Endocrine cell
- L-glutamate
- Melatonin
- Microvesicle
- Paracrine
- Pin ealocyte
- Serotonin
- V-ATPase
ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
- Agricultural and Biological Sciences (miscellaneous)
Cite this
Synaptic-like microvesicles, synaptic vesicle counterparts in endocrine cells, are involved in a novel regulatory mechanism for the synthesis and secretion of hormones. / Moriyama, Yoshinori; Hayashi, Mitsuko; Yamada, Hiroshi; Yatsushiro, Shouki; Ishio, Shougo; Yamamoto, Akitsugu.
In: Journal of Experimental Biology, Vol. 203, No. 1, 01.2000, p. 117-125.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Synaptic-like microvesicles, synaptic vesicle counterparts in endocrine cells, are involved in a novel regulatory mechanism for the synthesis and secretion of hormones
AU - Moriyama, Yoshinori
AU - Hayashi, Mitsuko
AU - Yamada, Hiroshi
AU - Yatsushiro, Shouki
AU - Ishio, Shougo
AU - Yamamoto, Akitsugu
PY - 2000/1
Y1 - 2000/1
N2 - Microvesicles in endocrine cells are the morphological and functional equivalent of neuronal synaptic vesicles. Microvesicles accumulate various neurotransmitters through a transmitter-specific vesicular transporter energized by vacuolar H+-ATPase. We found that mammalian pinealocytes, endocrine cells that synthesize and secrete melatonin, accumulate L-glutamate in their microvesicles and secrete it through exocytosis. Pinealocytes use L-glutamate as either a paracrine- or autocrine-like chemical transmitter in a receptor-mediated manner, resulting in inhibition of melatonin synthesis. In this article, we briefly describe the overall features of the microvesicle-mediated signal-transduction mechanism in the pineal gland and discuss the important role of acidic organelles in a novel regulatory mechanism for hormonal synthesis and secretion.
AB - Microvesicles in endocrine cells are the morphological and functional equivalent of neuronal synaptic vesicles. Microvesicles accumulate various neurotransmitters through a transmitter-specific vesicular transporter energized by vacuolar H+-ATPase. We found that mammalian pinealocytes, endocrine cells that synthesize and secrete melatonin, accumulate L-glutamate in their microvesicles and secrete it through exocytosis. Pinealocytes use L-glutamate as either a paracrine- or autocrine-like chemical transmitter in a receptor-mediated manner, resulting in inhibition of melatonin synthesis. In this article, we briefly describe the overall features of the microvesicle-mediated signal-transduction mechanism in the pineal gland and discuss the important role of acidic organelles in a novel regulatory mechanism for hormonal synthesis and secretion.
KW - Autocrine
KW - Endocrine cell
KW - L-glutamate
KW - Melatonin
KW - Microvesicle
KW - Paracrine
KW - Pin ealocyte
KW - Serotonin
KW - V-ATPase
UR - http://www.scopus.com/inward/record.url?scp=0033981087&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033981087&partnerID=8YFLogxK
M3 - Article
C2 - 10600680
AN - SCOPUS:0033981087
VL - 203
SP - 117
EP - 125
JO - Journal of Experimental Biology
JF - Journal of Experimental Biology
SN - 0022-0949
IS - 1
ER -