Symptoms and health-related quality of life in Japanese patients with primary biliary cholangitis

Minami Yagi, Atsushi Tanaka, Masanori Abe, Tadashi Namisaki, Hitoshi Yoshiji, Atsushi Takahashi, Hiromasa Ohira, Atsumasa Komori, Satoshi Yamagiwa, Kentaro Kikuchi, Tetsuya Yasunaka, Akinobu Takaki, Yoshiyuki Ueno, Akira Honda, Yasushi Matsuzaki, Hajime Takikawa

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Although patients with primary biliary cholangitis (PBC) experience a variety of symptoms that could impair health-related quality of life (HRQOL), no studies regarding symptoms and impact of PBC on HRQOL have been performed in Asian countries. Herein, we aimed to evaluate symptoms and HRQOL in Japanese PBC patients. We performed a multicenter, observational, cross-sectional study. The PBC-40 and the short form (SF)-36 were used as measures of symptoms and HRQOL. Four-hundred-ninety-six patients with PBC were enrolled. In the PBC-40, the average score was highest in the emotional domain, followed by the fatigue domain. The HRQOL measured using SF-36 was also impaired, especially in the physical and role-social components. After adjustments of variables, female sex, younger age at diagnosis, and lower serum albumin level were independently associated with fatigue scores, while a longer follow-up period and lower serum albumin levels were associated with itch scores.

Original languageEnglish
Article number12542
JournalScientific Reports
Volume8
Issue number1
DOIs
Publication statusPublished - Dec 1 2018

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Cholangitis
Quality of Life
Serum Albumin
Fatigue
Cross-Sectional Studies

ASJC Scopus subject areas

  • General

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Yagi, M., Tanaka, A., Abe, M., Namisaki, T., Yoshiji, H., Takahashi, A., ... Takikawa, H. (2018). Symptoms and health-related quality of life in Japanese patients with primary biliary cholangitis. Scientific Reports, 8(1), [12542]. https://doi.org/10.1038/s41598-018-31063-8

Symptoms and health-related quality of life in Japanese patients with primary biliary cholangitis. / Yagi, Minami; Tanaka, Atsushi; Abe, Masanori; Namisaki, Tadashi; Yoshiji, Hitoshi; Takahashi, Atsushi; Ohira, Hiromasa; Komori, Atsumasa; Yamagiwa, Satoshi; Kikuchi, Kentaro; Yasunaka, Tetsuya; Takaki, Akinobu; Ueno, Yoshiyuki; Honda, Akira; Matsuzaki, Yasushi; Takikawa, Hajime.

In: Scientific Reports, Vol. 8, No. 1, 12542, 01.12.2018.

Research output: Contribution to journalArticle

Yagi, M, Tanaka, A, Abe, M, Namisaki, T, Yoshiji, H, Takahashi, A, Ohira, H, Komori, A, Yamagiwa, S, Kikuchi, K, Yasunaka, T, Takaki, A, Ueno, Y, Honda, A, Matsuzaki, Y & Takikawa, H 2018, 'Symptoms and health-related quality of life in Japanese patients with primary biliary cholangitis', Scientific Reports, vol. 8, no. 1, 12542. https://doi.org/10.1038/s41598-018-31063-8
Yagi, Minami ; Tanaka, Atsushi ; Abe, Masanori ; Namisaki, Tadashi ; Yoshiji, Hitoshi ; Takahashi, Atsushi ; Ohira, Hiromasa ; Komori, Atsumasa ; Yamagiwa, Satoshi ; Kikuchi, Kentaro ; Yasunaka, Tetsuya ; Takaki, Akinobu ; Ueno, Yoshiyuki ; Honda, Akira ; Matsuzaki, Yasushi ; Takikawa, Hajime. / Symptoms and health-related quality of life in Japanese patients with primary biliary cholangitis. In: Scientific Reports. 2018 ; Vol. 8, No. 1.
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