Sustained tubulointerstitial inflammation in kidney with severe leptospirosis

Keiko Tanaka, Katsuyuki Tanabe, Naoko Nishii, Keiichi Takiue, Hitoshi Sugiyama, Jun Wada

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Leptospirosis is frequently associated with acute kidney injury. Some survivors are known to progress to chronic kidney disease due to sustained tubulointerstitial inflammation. We present a case of severe leptospirosis with acute renal failure. Although antibiotic therapy resolved the infection, moderate renal dysfunction remained. A renal biopsy demonstrated marked inflammatory infiltration in the tubules and interstitium. Many of the inflammatory cells were CD68-positive monocytes/macrophages, predominantly M1 phenotype. An intermediate dose of oral corticosteroids normalized the patient’s serum creatinine levels. We suggest that corticosteroid therapy may be a therapeutic option for some patients with sustained tubulointerstitial nephritis who survive severe leptospirosis.

Original languageEnglish
Pages (from-to)1179-1184
Number of pages6
JournalInternal Medicine
Volume56
Issue number10
DOIs
Publication statusPublished - 2017

Fingerprint

Leptospirosis
Inflammation
Kidney
Acute Kidney Injury
Adrenal Cortex Hormones
Interstitial Nephritis
Chronic Renal Insufficiency
Survivors
Monocytes
Creatinine
Therapeutics
Macrophages
Anti-Bacterial Agents
Phenotype
Biopsy
Infection
Serum

Keywords

  • Acute kidney injury
  • Leptospirosis
  • Macrophages

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Sustained tubulointerstitial inflammation in kidney with severe leptospirosis. / Tanaka, Keiko; Tanabe, Katsuyuki; Nishii, Naoko; Takiue, Keiichi; Sugiyama, Hitoshi; Wada, Jun.

In: Internal Medicine, Vol. 56, No. 10, 2017, p. 1179-1184.

Research output: Contribution to journalArticle

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