Susceptibilities of Enterococcus faecium, PRSP and MRSA to RP59500 and their correlations with those to other drugs

Matsuhisa Inoue, Akira Saito, Yoshinori Shimizu, Akira Watanabe, Tadashi Kawai, Mutsumu Hayashi, Harushige Kanno, Setsuko Kubo, Kimiko Ubukata, Jun Igari, Toyoko Oguri, Yoshio Kobayashi, Kouya Shiba, Mitsuo Sakamoto, Yutaka Tokue, Keizo Yamaguchi, Shuichi Miyazaki, Takashi Inamatsu, Jingoro Shimada, Mitsuo KakuAkio Kuga, Satoshi Ichiyama, Masanori Aihara, Minoru Higashitsutsumi, Masako Sakamoto, Shigeru Kohno, Kazunori Tomono, Yoichi Hlrakata, Atsushi Saito, Nobuchika Kusano, Yasushi Ueda

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3 Citations (Scopus)


Investigations on emergence of vancomycin-resistant Enterococciis faecium (VREF) which has recently been attracting attention, especially in the Western contries, have been conducted in Japan. A total of 1,239 isolates ofE.faecium were collected from 19 institutions during the period of April 1995 and June 1996, in the purpose of evaluating susceptibilities to variety of antimicrobial agents, including RP59500 and vancomycin (VCM), and detecting vancomycin-resistant genes (van genes). Susceptibilities of penicillin-resistant Streptococcuspneumoniae (PRSP) and methicillin-resistant Staphylococctis aweus (MRSA) were also studied. As a result, 2 isolates of E.faecium were found to be moderately resistant to VCM showing MIC of 8/fg/ml though the final identification in species level and the detection of van genes by PCR method have not been completed. On the other hand, there detected no MRSA nor PRSP showing moderately resistant or resistant to VCM. It was concluded that RP59500 and VCM possessed favorable activity against clinically isolated E. faeciiim, PRSP and MRSA. Among other species of enterococci, moderately resistant strains to VCM showing MIC of 8/ig/ml were detected; 10 isolates of E. gallinarum, 4 of E. casseliflavus and 2 of E. flavescens. In those isolates , vanCl and \anC2 were detected by PCR, and vanB was also detected in a isolates ofE. gallinamm simultaneously.

Original languageEnglish
Pages (from-to)310-311
Number of pages2
JournalJapanese Journal of Antibiotics
Issue number4
Publication statusPublished - 1999
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases


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