TY - JOUR
T1 - Susceptibilities of Enterococcus faecium, PRSP and MRSA to RP59500 and their correlations with those to other drugs
AU - Inoue, Matsuhisa
AU - Saito, Akira
AU - Shimizu, Yoshinori
AU - Watanabe, Akira
AU - Kawai, Tadashi
AU - Hayashi, Mutsumu
AU - Kanno, Harushige
AU - Kubo, Setsuko
AU - Ubukata, Kimiko
AU - Igari, Jun
AU - Oguri, Toyoko
AU - Kobayashi, Yoshio
AU - Shiba, Kouya
AU - Sakamoto, Mitsuo
AU - Tokue, Yutaka
AU - Yamaguchi, Keizo
AU - Miyazaki, Shuichi
AU - Inamatsu, Takashi
AU - Shimada, Jingoro
AU - Kaku, Mitsuo
AU - Kuga, Akio
AU - Ichiyama, Satoshi
AU - Aihara, Masanori
AU - Higashitsutsumi, Minoru
AU - Sakamoto, Masako
AU - Kohno, Shigeru
AU - Tomono, Kazunori
AU - Hlrakata, Yoichi
AU - Saito, Atsushi
AU - Kusano, Nobuchika
AU - Ueda, Yasushi
PY - 1999
Y1 - 1999
N2 - Investigations on emergence of vancomycin-resistant Enterococciis faecium (VREF) which has recently been attracting attention, especially in the Western contries, have been conducted in Japan. A total of 1,239 isolates ofE.faecium were collected from 19 institutions during the period of April 1995 and June 1996, in the purpose of evaluating susceptibilities to variety of antimicrobial agents, including RP59500 and vancomycin (VCM), and detecting vancomycin-resistant genes (van genes). Susceptibilities of penicillin-resistant Streptococcuspneumoniae (PRSP) and methicillin-resistant Staphylococctis aweus (MRSA) were also studied. As a result, 2 isolates of E.faecium were found to be moderately resistant to VCM showing MIC of 8/fg/ml though the final identification in species level and the detection of van genes by PCR method have not been completed. On the other hand, there detected no MRSA nor PRSP showing moderately resistant or resistant to VCM. It was concluded that RP59500 and VCM possessed favorable activity against clinically isolated E. faeciiim, PRSP and MRSA. Among other species of enterococci, moderately resistant strains to VCM showing MIC of 8/ig/ml were detected; 10 isolates of E. gallinarum, 4 of E. casseliflavus and 2 of E. flavescens. In those isolates , vanCl and \anC2 were detected by PCR, and vanB was also detected in a isolates ofE. gallinamm simultaneously.
AB - Investigations on emergence of vancomycin-resistant Enterococciis faecium (VREF) which has recently been attracting attention, especially in the Western contries, have been conducted in Japan. A total of 1,239 isolates ofE.faecium were collected from 19 institutions during the period of April 1995 and June 1996, in the purpose of evaluating susceptibilities to variety of antimicrobial agents, including RP59500 and vancomycin (VCM), and detecting vancomycin-resistant genes (van genes). Susceptibilities of penicillin-resistant Streptococcuspneumoniae (PRSP) and methicillin-resistant Staphylococctis aweus (MRSA) were also studied. As a result, 2 isolates of E.faecium were found to be moderately resistant to VCM showing MIC of 8/fg/ml though the final identification in species level and the detection of van genes by PCR method have not been completed. On the other hand, there detected no MRSA nor PRSP showing moderately resistant or resistant to VCM. It was concluded that RP59500 and VCM possessed favorable activity against clinically isolated E. faeciiim, PRSP and MRSA. Among other species of enterococci, moderately resistant strains to VCM showing MIC of 8/ig/ml were detected; 10 isolates of E. gallinarum, 4 of E. casseliflavus and 2 of E. flavescens. In those isolates , vanCl and \anC2 were detected by PCR, and vanB was also detected in a isolates ofE. gallinamm simultaneously.
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M3 - Article
C2 - 10396687
AN - SCOPUS:0032890645
VL - 52
SP - 310
EP - 311
JO - The Journal of antibiotics. Ser. B
JF - The Journal of antibiotics. Ser. B
SN - 0368-2781
IS - 4
ER -
