Susceptibilities of Enterococcus faecium, PRSP and MRSA to RP59500 and their correlations with those to other drugs

Matsuhisa Inoue; Akira Saito; Yoshinori Shimizu; Akira Watanabe; Tadashi Kawai; Mutsumu Hayashi; Harushige Kanno; Setsuko Kubo; Kimiko Ubukata; Jun Igari; Toyoko Oguri; Yoshio Kobayashi; Kouya Shiba; Mitsuo Sakamoto; Yutaka Tokue; Keizo Yamaguchi; Shuichi Miyazaki; Takashi Inamatsu; Jingoro Shimada; Mitsuo Kaku; Akio Kuga; Satoshi Ichiyama; Masanori Aihara; Minoru Higashitsutsumi; Masako Sakamoto; Shigeru Kohno; Kazunori Tomono; Yoichi Hlrakata; Atsushi Saito; Nobuchika Kusano; Yasushi Ueda

Susceptibilities of Enterococcus faecium, PRSP and MRSA to RP59500 and their correlations with those to other drugs

Matsuhisa Inoue, Akira Saito, Yoshinori Shimizu, Akira Watanabe, Tadashi Kawai, Mutsumu Hayashi, Harushige Kanno, Setsuko Kubo, Kimiko Ubukata, Jun Igari, Toyoko Oguri, Yoshio Kobayashi, Kouya Shiba, Mitsuo Sakamoto, Yutaka Tokue, Keizo Yamaguchi, Shuichi Miyazaki, Takashi Inamatsu, Jingoro Shimada, Mitsuo KakuAkio Kuga, Satoshi Ichiyama, Masanori Aihara, Minoru Higashitsutsumi, Masako Sakamoto, Shigeru Kohno, Kazunori Tomono, Yoichi Hlrakata, Atsushi Saito, Nobuchika Kusano, Yasushi Ueda

University Hospital

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Investigations on emergence of vancomycin-resistant Enterococciis faecium (VREF) which has recently been attracting attention, especially in the Western contries, have been conducted in Japan. A total of 1,239 isolates ofE.faecium were collected from 19 institutions during the period of April 1995 and June 1996, in the purpose of evaluating susceptibilities to variety of antimicrobial agents, including RP59500 and vancomycin (VCM), and detecting vancomycin-resistant genes (van genes). Susceptibilities of penicillin-resistant Streptococcuspneumoniae (PRSP) and methicillin-resistant Staphylococctis aweus (MRSA) were also studied. As a result, 2 isolates of E.faecium were found to be moderately resistant to VCM showing MIC of 8/fg/ml though the final identification in species level and the detection of van genes by PCR method have not been completed. On the other hand, there detected no MRSA nor PRSP showing moderately resistant or resistant to VCM. It was concluded that RP59500 and VCM possessed favorable activity against clinically isolated E. faeciiim, PRSP and MRSA. Among other species of enterococci, moderately resistant strains to VCM showing MIC of 8/ig/ml were detected; 10 isolates of E. gallinarum, 4 of E. casseliflavus and 2 of E. flavescens. In those isolates , vanCl and \anC2 were detected by PCR, and vanB was also detected in a isolates ofE. gallinamm simultaneously.

Original language	English
Pages (from-to)	310-311
Number of pages	2
Journal	Japanese Journal of Antibiotics
Volume	52
Issue number	4
Publication status	Published - 1999

ASJC Scopus subject areas

Microbiology (medical)
Pharmacology (medical)
Infectious Diseases

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Inoue, M., Saito, A., Shimizu, Y., Watanabe, A., Kawai, T., Hayashi, M., Kanno, H., Kubo, S., Ubukata, K., Igari, J., Oguri, T., Kobayashi, Y., Shiba, K., Sakamoto, M., Tokue, Y., Yamaguchi, K., Miyazaki, S., Inamatsu, T., Shimada, J., ... Ueda, Y. (1999). Susceptibilities of Enterococcus faecium, PRSP and MRSA to RP59500 and their correlations with those to other drugs. Japanese Journal of Antibiotics, 52(4), 310-311.

Susceptibilities of Enterococcus faecium, PRSP and MRSA to RP59500 and their correlations with those to other drugs. / Inoue, Matsuhisa; Saito, Akira; Shimizu, Yoshinori; Watanabe, Akira; Kawai, Tadashi; Hayashi, Mutsumu; Kanno, Harushige; Kubo, Setsuko; Ubukata, Kimiko; Igari, Jun; Oguri, Toyoko; Kobayashi, Yoshio; Shiba, Kouya; Sakamoto, Mitsuo; Tokue, Yutaka; Yamaguchi, Keizo; Miyazaki, Shuichi; Inamatsu, Takashi; Shimada, Jingoro; Kaku, Mitsuo; Kuga, Akio; Ichiyama, Satoshi; Aihara, Masanori; Higashitsutsumi, Minoru; Sakamoto, Masako; Kohno, Shigeru; Tomono, Kazunori; Hlrakata, Yoichi; Saito, Atsushi; Kusano, Nobuchika; Ueda, Yasushi.

In: Japanese Journal of Antibiotics, Vol. 52, No. 4, 1999, p. 310-311.

Research output: Contribution to journal › Article › peer-review

Inoue, M, Saito, A, Shimizu, Y, Watanabe, A, Kawai, T, Hayashi, M, Kanno, H, Kubo, S, Ubukata, K, Igari, J, Oguri, T, Kobayashi, Y, Shiba, K, Sakamoto, M, Tokue, Y, Yamaguchi, K, Miyazaki, S, Inamatsu, T, Shimada, J, Kaku, M, Kuga, A, Ichiyama, S, Aihara, M, Higashitsutsumi, M, Sakamoto, M, Kohno, S, Tomono, K, Hlrakata, Y, Saito, A, Kusano, N & Ueda, Y 1999, 'Susceptibilities of Enterococcus faecium, PRSP and MRSA to RP59500 and their correlations with those to other drugs', Japanese Journal of Antibiotics, vol. 52, no. 4, pp. 310-311.

Inoue, Matsuhisa ; Saito, Akira ; Shimizu, Yoshinori ; Watanabe, Akira ; Kawai, Tadashi ; Hayashi, Mutsumu ; Kanno, Harushige ; Kubo, Setsuko ; Ubukata, Kimiko ; Igari, Jun ; Oguri, Toyoko ; Kobayashi, Yoshio ; Shiba, Kouya ; Sakamoto, Mitsuo ; Tokue, Yutaka ; Yamaguchi, Keizo ; Miyazaki, Shuichi ; Inamatsu, Takashi ; Shimada, Jingoro ; Kaku, Mitsuo ; Kuga, Akio ; Ichiyama, Satoshi ; Aihara, Masanori ; Higashitsutsumi, Minoru ; Sakamoto, Masako ; Kohno, Shigeru ; Tomono, Kazunori ; Hlrakata, Yoichi ; Saito, Atsushi ; Kusano, Nobuchika ; Ueda, Yasushi. / Susceptibilities of Enterococcus faecium, PRSP and MRSA to RP59500 and their correlations with those to other drugs. In: Japanese Journal of Antibiotics. 1999 ; Vol. 52, No. 4. pp. 310-311.

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abstract = "Investigations on emergence of vancomycin-resistant Enterococciis faecium (VREF) which has recently been attracting attention, especially in the Western contries, have been conducted in Japan. A total of 1,239 isolates ofE.faecium were collected from 19 institutions during the period of April 1995 and June 1996, in the purpose of evaluating susceptibilities to variety of antimicrobial agents, including RP59500 and vancomycin (VCM), and detecting vancomycin-resistant genes (van genes). Susceptibilities of penicillin-resistant Streptococcuspneumoniae (PRSP) and methicillin-resistant Staphylococctis aweus (MRSA) were also studied. As a result, 2 isolates of E.faecium were found to be moderately resistant to VCM showing MIC of 8/fg/ml though the final identification in species level and the detection of van genes by PCR method have not been completed. On the other hand, there detected no MRSA nor PRSP showing moderately resistant or resistant to VCM. It was concluded that RP59500 and VCM possessed favorable activity against clinically isolated E. faeciiim, PRSP and MRSA. Among other species of enterococci, moderately resistant strains to VCM showing MIC of 8/ig/ml were detected; 10 isolates of E. gallinarum, 4 of E. casseliflavus and 2 of E. flavescens. In those isolates , vanCl and \anC2 were detected by PCR, and vanB was also detected in a isolates ofE. gallinamm simultaneously.",

author = "Matsuhisa Inoue and Akira Saito and Yoshinori Shimizu and Akira Watanabe and Tadashi Kawai and Mutsumu Hayashi and Harushige Kanno and Setsuko Kubo and Kimiko Ubukata and Jun Igari and Toyoko Oguri and Yoshio Kobayashi and Kouya Shiba and Mitsuo Sakamoto and Yutaka Tokue and Keizo Yamaguchi and Shuichi Miyazaki and Takashi Inamatsu and Jingoro Shimada and Mitsuo Kaku and Akio Kuga and Satoshi Ichiyama and Masanori Aihara and Minoru Higashitsutsumi and Masako Sakamoto and Shigeru Kohno and Kazunori Tomono and Yoichi Hlrakata and Atsushi Saito and Nobuchika Kusano and Yasushi Ueda",

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AU - Inoue, Matsuhisa

AU - Saito, Akira

AU - Shimizu, Yoshinori

AU - Watanabe, Akira

AU - Kawai, Tadashi

AU - Hayashi, Mutsumu

AU - Kanno, Harushige

AU - Kubo, Setsuko

AU - Ubukata, Kimiko

AU - Igari, Jun

AU - Oguri, Toyoko

AU - Kobayashi, Yoshio

AU - Shiba, Kouya

AU - Sakamoto, Mitsuo

AU - Tokue, Yutaka

AU - Yamaguchi, Keizo

AU - Miyazaki, Shuichi

AU - Inamatsu, Takashi

AU - Shimada, Jingoro

AU - Kaku, Mitsuo

AU - Kuga, Akio

AU - Ichiyama, Satoshi

AU - Aihara, Masanori

AU - Higashitsutsumi, Minoru

AU - Sakamoto, Masako

AU - Kohno, Shigeru

AU - Tomono, Kazunori

AU - Hlrakata, Yoichi

AU - Saito, Atsushi

AU - Kusano, Nobuchika

AU - Ueda, Yasushi

PY - 1999

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N2 - Investigations on emergence of vancomycin-resistant Enterococciis faecium (VREF) which has recently been attracting attention, especially in the Western contries, have been conducted in Japan. A total of 1,239 isolates ofE.faecium were collected from 19 institutions during the period of April 1995 and June 1996, in the purpose of evaluating susceptibilities to variety of antimicrobial agents, including RP59500 and vancomycin (VCM), and detecting vancomycin-resistant genes (van genes). Susceptibilities of penicillin-resistant Streptococcuspneumoniae (PRSP) and methicillin-resistant Staphylococctis aweus (MRSA) were also studied. As a result, 2 isolates of E.faecium were found to be moderately resistant to VCM showing MIC of 8/fg/ml though the final identification in species level and the detection of van genes by PCR method have not been completed. On the other hand, there detected no MRSA nor PRSP showing moderately resistant or resistant to VCM. It was concluded that RP59500 and VCM possessed favorable activity against clinically isolated E. faeciiim, PRSP and MRSA. Among other species of enterococci, moderately resistant strains to VCM showing MIC of 8/ig/ml were detected; 10 isolates of E. gallinarum, 4 of E. casseliflavus and 2 of E. flavescens. In those isolates , vanCl and \anC2 were detected by PCR, and vanB was also detected in a isolates ofE. gallinamm simultaneously.

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