TY - JOUR
T1 - Susceptibilities of bacteria isolated from patients with lower respiratory infectious diseases to antibiotics (1997)
AU - Ikemoto, Hideo
AU - Watanabe, Kazuyoshi
AU - Mori, Takeshi
AU - Igari, Jun
AU - Oguri, Toyoko
AU - Terai, Tsugio
AU - Inoue, Hiroshi
AU - Nakadate, Toshihide
AU - Ito, Chuichi
AU - Yoshida, Takeshi
AU - Ohno, Isao
AU - Okada, Siiinji
AU - Arakawa, Masaaki
AU - Igarashi, Kenichi
AU - Okada, Masahiko
AU - Ozaki, Kyoko
AU - Aoki, Nobuki
AU - Kltamura, Nobuko
AU - Sekine, Osamu
AU - Suzuki, Yasutosmi
AU - Nakata, Kouichiro
AU - Nakatani, Tatsuo
AU - Inagawa, Hiroko
AU - Kudo, Kouichiro
AU - Kondo, Tadashi
AU - Kobayashi, Hiroyuki
AU - Kawai, Shin
AU - Takayasu, Satoshi
AU - Shimada, Kaoru
AU - Nakano, Kunio
AU - Takamori, Mikio
AU - Yokouchi, Hlroshi
AU - Ito, A. K.Ira
AU - Sumitomo, Midori
AU - Matsushima, Toshiharu
AU - Niki, Yoshihito
AU - Ando, Masayuki
AU - Suga, Moritaka
AU - Sato, Keizou
AU - Tosaka, Masakazu
AU - Kohno, Shigeru
AU - Tomono, Kazunori
AU - Hlrakata, Yoichi
AU - Izumikawa, Koichi
AU - Yamaguchi, Toshiyuki
AU - Mochida, Cliikako
AU - Nasu, Masaru
AU - Ito, Morio
AU - Yamasaki, Tohru
AU - Nakano, Tadao
AU - Saito, Atsushi
AU - Touyama, Masato
AU - Yamane, Nobuhisa
AU - Kusano, Nobutika
N1 - Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 1999
Y1 - 1999
N2 - bacteria isolated from the patients with lower respiratory tract infections were collected by institutions located throughout Japan, since 1981. IKEMOTO et al. have been investigating susceptibilities of these isolates to various antibacterial agents and antibiotics, and analyzed some characteristics of the patients and isolates from them each year. Results obtained from these investigations are discussed. In these 17 institutions around the entire Japan, 512 strains of presumably etiological bacteria were isolated mainly from the sputa of 440 patients with lower respiratory tract infections during the period from October in 1997 to September in 1998. MICs of various antibacterial agents and antibiotics were determined against 100 strains of Staphylococctts aureus, 81 strains of Streptococcus pneiiinoniae, 85 strains of Haemophilus influenzae, 71 strains of Pseiidomonas aeruginosa (non-mucoid strains), 27 strains of Pseudomonas aeruginosa (mucoid strains), 33 strains oïMoraxella subgenus Branhamella catarrhalis, 17 strains of Klebsiella pnewnoniae etc., and the susceptibilities of these strains were assessed except for those strains that died during transportation. S. aweus strains for which MICs of oxacillin (MPIPC) were higher than 4/ig/ml (methicillin-resistant S. aureits: MRSA) accounted for 55.0%. The frequency of the drug resistant bacteria decreased comparing to the previous year's 67.3%. Arbekacin (ABK) and vancomycin (VCM) showed the most potent activities against MRSA. Imipenem (IPM) and panipenem (PAPM) of carbapenems showed the most potent activities with MIC80s of 0.063//g/ml against S. pnewnoniae. The frequency of penicillin (PC)-intermediate S. pnewnoniae (PISPJ+PCresistant S. pnewnoniae (PRSP) had decreased gradually, that is, in 1995 the frequency of it was 40.3%, but that was 30.9% in 1997. Against H. influenzae and M.(B.) catarrhalis, all the drugs showed good activities. But the sensitive strains of them against ceftazidime (CAZ) had decreased in 1997, compared those in 1995 and 1996. Meropenem (MEPM), IPM and tobramycin (TOB) showed the most potent activity against P. aeruginosa (mucoid strains). And TOB and ciprofloxacin (CPFX) showed the most potent activities against P. aeruginosa (non-mucoid strains). All drugs except ampicillin (ABPC) were more active against K. pneiiinoniae in 1997 than that in 1996. Also, we investigated year to year changes in the characteristics of patients, their respiratory infectious diseases, and the etiology. The examination of age distribution indicated that the proportion of patients with ages over 70 years was 45.5% of all the patients showing a slight increase year by year. About the proportion of diagnosed diseases, not so particular changes were recognized as follows: Bacterial pneumonia and chronic bronchitis were the most frequent with 33.6% and 29.1%, respectively. Number of strains isolated from patients before administration of antibiotics were more than those after administration of them in chronic bronchitis, but these had reversed in bacterial pneumonia. The tendency in bacterial pneumonia had been acknowledged since 1995. The increase of S. atireus and P. aeruginosa (both mucoid and non-mucoid strains) isolated after administration of antibiotics, has suggested the decrease of the susceptibility of these strains against antibiotics. Administration of antibiotics has changed the results of the frequency of isolation of bacterial species. Bacterial isolations before administration of antibiotics were as follows: S. pnewnoniae 24.5%, H. influenzae 21.4%, S. aweus 18.4% and P. aeruginosa 12.2%. The frequencies of S. aureus decreased after antibiotics administration over 15 days, but the frequencies of P. aeruginosa was not affected. The frequencies of P. aeruginosa was 47.8% after administration over 15 days. From patients administered antibiotics of penicillins and cephems, S. aureus was mainly detected with 31.7~58.3%, and from patients administered antibiotics of macrolides, P. aeruginosa was mainly detected with about 50%.
AB - bacteria isolated from the patients with lower respiratory tract infections were collected by institutions located throughout Japan, since 1981. IKEMOTO et al. have been investigating susceptibilities of these isolates to various antibacterial agents and antibiotics, and analyzed some characteristics of the patients and isolates from them each year. Results obtained from these investigations are discussed. In these 17 institutions around the entire Japan, 512 strains of presumably etiological bacteria were isolated mainly from the sputa of 440 patients with lower respiratory tract infections during the period from October in 1997 to September in 1998. MICs of various antibacterial agents and antibiotics were determined against 100 strains of Staphylococctts aureus, 81 strains of Streptococcus pneiiinoniae, 85 strains of Haemophilus influenzae, 71 strains of Pseiidomonas aeruginosa (non-mucoid strains), 27 strains of Pseudomonas aeruginosa (mucoid strains), 33 strains oïMoraxella subgenus Branhamella catarrhalis, 17 strains of Klebsiella pnewnoniae etc., and the susceptibilities of these strains were assessed except for those strains that died during transportation. S. aweus strains for which MICs of oxacillin (MPIPC) were higher than 4/ig/ml (methicillin-resistant S. aureits: MRSA) accounted for 55.0%. The frequency of the drug resistant bacteria decreased comparing to the previous year's 67.3%. Arbekacin (ABK) and vancomycin (VCM) showed the most potent activities against MRSA. Imipenem (IPM) and panipenem (PAPM) of carbapenems showed the most potent activities with MIC80s of 0.063//g/ml against S. pnewnoniae. The frequency of penicillin (PC)-intermediate S. pnewnoniae (PISPJ+PCresistant S. pnewnoniae (PRSP) had decreased gradually, that is, in 1995 the frequency of it was 40.3%, but that was 30.9% in 1997. Against H. influenzae and M.(B.) catarrhalis, all the drugs showed good activities. But the sensitive strains of them against ceftazidime (CAZ) had decreased in 1997, compared those in 1995 and 1996. Meropenem (MEPM), IPM and tobramycin (TOB) showed the most potent activity against P. aeruginosa (mucoid strains). And TOB and ciprofloxacin (CPFX) showed the most potent activities against P. aeruginosa (non-mucoid strains). All drugs except ampicillin (ABPC) were more active against K. pneiiinoniae in 1997 than that in 1996. Also, we investigated year to year changes in the characteristics of patients, their respiratory infectious diseases, and the etiology. The examination of age distribution indicated that the proportion of patients with ages over 70 years was 45.5% of all the patients showing a slight increase year by year. About the proportion of diagnosed diseases, not so particular changes were recognized as follows: Bacterial pneumonia and chronic bronchitis were the most frequent with 33.6% and 29.1%, respectively. Number of strains isolated from patients before administration of antibiotics were more than those after administration of them in chronic bronchitis, but these had reversed in bacterial pneumonia. The tendency in bacterial pneumonia had been acknowledged since 1995. The increase of S. atireus and P. aeruginosa (both mucoid and non-mucoid strains) isolated after administration of antibiotics, has suggested the decrease of the susceptibility of these strains against antibiotics. Administration of antibiotics has changed the results of the frequency of isolation of bacterial species. Bacterial isolations before administration of antibiotics were as follows: S. pnewnoniae 24.5%, H. influenzae 21.4%, S. aweus 18.4% and P. aeruginosa 12.2%. The frequencies of S. aureus decreased after antibiotics administration over 15 days, but the frequencies of P. aeruginosa was not affected. The frequencies of P. aeruginosa was 47.8% after administration over 15 days. From patients administered antibiotics of penicillins and cephems, S. aureus was mainly detected with 31.7~58.3%, and from patients administered antibiotics of macrolides, P. aeruginosa was mainly detected with about 50%.
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M3 - Article
C2 - 10480048
AN - SCOPUS:0033021767
VL - 52
SP - 392
EP - 397
JO - The Journal of antibiotics. Ser. B
JF - The Journal of antibiotics. Ser. B
SN - 0368-2781
IS - 5
ER -