Survey of human group C rotaviruses in Japan during the winter of 1992 to 1993

Mitsutaka Kuzuya, Ritsushi Fujii, Masako Hamano, Masao Yamada, Kuniko Shinozaki, Akira Sasagawa, Sumiyo Hasegawa, Hiroyoshi Kawamoto, Kazuo Matsumoto, Ayumi Kawamoto, Asao Itagaki, Sadayuki Funatsumaru, Syozo Urasawa

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Abstract

Fecal specimens from patients with acute diarrhea were collected from 10 prefectures in Japan over a 6-month period (November 1992 to April 1993), and the specimens that were negative for human group A rotaviruses were screened for the presence of human group C rotaviruses (CHRVs) by the reverse passive hemagglutination test. Of 784 specimens examined, 53 samples (6.8%) that were collected in 7 of 10 prefectures were positive for CHRV, indicating that CHRVs are widely distributed across Japan. Most of the CHRV isolates were detected in March and April, and CHRVs mainly prevailed in children ages 3 to 8 years. The genome electropherotypes of eight strains isolated in five individual prefectures were surprisingly similar to each other and were different from those of CHRV strains isolated to date. The outer capsid glycoprotein (VP7) gene homologies of the isolates retrieved in 1993 were subsequently analyzed by the dot blot hybridization method. As a result, the VP7 genes of the isolates revealed very high levels of homology not only with each other but also with the VP7 gene of the OK118 strain isolated in 1988. These results suggest that a large-scale outbreak of CHRV occurred during the winter of 1992 and 1993 in Japan.

Original languageEnglish
Pages (from-to)6-10
Number of pages5
JournalJournal of Clinical Microbiology
Volume36
Issue number1
Publication statusPublished - Jan 1998

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Rotavirus
Japan
Genes
Hemagglutination Tests
Capsid
Disease Outbreaks
Diarrhea
Glycoproteins
Genome
Surveys and Questionnaires

ASJC Scopus subject areas

  • Microbiology (medical)
  • Microbiology

Cite this

Kuzuya, M., Fujii, R., Hamano, M., Yamada, M., Shinozaki, K., Sasagawa, A., ... Urasawa, S. (1998). Survey of human group C rotaviruses in Japan during the winter of 1992 to 1993. Journal of Clinical Microbiology, 36(1), 6-10.

Survey of human group C rotaviruses in Japan during the winter of 1992 to 1993. / Kuzuya, Mitsutaka; Fujii, Ritsushi; Hamano, Masako; Yamada, Masao; Shinozaki, Kuniko; Sasagawa, Akira; Hasegawa, Sumiyo; Kawamoto, Hiroyoshi; Matsumoto, Kazuo; Kawamoto, Ayumi; Itagaki, Asao; Funatsumaru, Sadayuki; Urasawa, Syozo.

In: Journal of Clinical Microbiology, Vol. 36, No. 1, 01.1998, p. 6-10.

Research output: Contribution to journalArticle

Kuzuya, M, Fujii, R, Hamano, M, Yamada, M, Shinozaki, K, Sasagawa, A, Hasegawa, S, Kawamoto, H, Matsumoto, K, Kawamoto, A, Itagaki, A, Funatsumaru, S & Urasawa, S 1998, 'Survey of human group C rotaviruses in Japan during the winter of 1992 to 1993', Journal of Clinical Microbiology, vol. 36, no. 1, pp. 6-10.
Kuzuya M, Fujii R, Hamano M, Yamada M, Shinozaki K, Sasagawa A et al. Survey of human group C rotaviruses in Japan during the winter of 1992 to 1993. Journal of Clinical Microbiology. 1998 Jan;36(1):6-10.
Kuzuya, Mitsutaka ; Fujii, Ritsushi ; Hamano, Masako ; Yamada, Masao ; Shinozaki, Kuniko ; Sasagawa, Akira ; Hasegawa, Sumiyo ; Kawamoto, Hiroyoshi ; Matsumoto, Kazuo ; Kawamoto, Ayumi ; Itagaki, Asao ; Funatsumaru, Sadayuki ; Urasawa, Syozo. / Survey of human group C rotaviruses in Japan during the winter of 1992 to 1993. In: Journal of Clinical Microbiology. 1998 ; Vol. 36, No. 1. pp. 6-10.
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