Surgical Resection for Local and Lateral Lymph Node Recurrence of MSI-high Cecal Cancer with the BRAF V600E Mutation

Fuminori Teraishi; Atsushi Jikuhara; Ryunosuke Ogawa; Toshiyoshi Fujiwara

doi:10.18926/AMO/64043

Surgical Resection for Local and Lateral Lymph Node Recurrence of MSI-high Cecal Cancer with the BRAF V600E Mutation

Fuminori Teraishi, Atsushi Jikuhara, Ryunosuke Ogawa, Toshiyoshi Fujiwara

Research output: Contribution to journal › Article › peer-review

Abstract

An 84-year-old female underwent open right hemicolectomy with D3 lymph node dissection for cecal cancer, pathologically identified as pT4aN2M0 Stage IIIc and BRAF mutation-positive. Due to early recurrence of abdominal wall and right lateral lymph nodes, the patient was treated with FOLFOXIRI+Bevacizumab. Imaging after 5 courses of chemotherapy found tumor shrinkage and no new metastases. The patient did not tolerate chemotherapy well, and tumor resection was performed. Microsatellite instability (MSI) testing using multiplex polymerase chain reaction (PCR) fragment analysis revealed MSI-high status. The patient is currently recurrence-free without chemotherapy at 1 year postoperatively. BRAF-mutated colorectal cancer has a poor prognosis, and may require resection of the metastatic or recurrent tumor after comprehensive evaluation.

Original language	English
Pages (from-to)	605-608
Number of pages	4
Journal	Acta medica Okayama
Volume	76
Issue number	5
DOIs	https://doi.org/10.18926/AMO/64043
Publication status	Published - 2022

Keywords

Braf v600e mutation
Cecal cancer
Msi-high

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.18926/AMO/64043

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title = "Surgical Resection for Local and Lateral Lymph Node Recurrence of MSI-high Cecal Cancer with the BRAF V600E Mutation",

abstract = "An 84-year-old female underwent open right hemicolectomy with D3 lymph node dissection for cecal cancer, pathologically identified as pT4aN2M0 Stage IIIc and BRAF mutation-positive. Due to early recurrence of abdominal wall and right lateral lymph nodes, the patient was treated with FOLFOXIRI+Bevacizumab. Imaging after 5 courses of chemotherapy found tumor shrinkage and no new metastases. The patient did not tolerate chemotherapy well, and tumor resection was performed. Microsatellite instability (MSI) testing using multiplex polymerase chain reaction (PCR) fragment analysis revealed MSI-high status. The patient is currently recurrence-free without chemotherapy at 1 year postoperatively. BRAF-mutated colorectal cancer has a poor prognosis, and may require resection of the metastatic or recurrent tumor after comprehensive evaluation.",

keywords = "Braf v600e mutation, Cecal cancer, Msi-high",

author = "Fuminori Teraishi and Atsushi Jikuhara and Ryunosuke Ogawa and Toshiyoshi Fujiwara",

note = "Funding Information: We would like to express our deepest gratitude to Dr. Kayoko Iwatani, of the Department of Pathology, Fukuyama Medical Association, for her guidance on histopathological diagnosis in completing this article. Publisher Copyright: {\textcopyright} 2022 by Okayama University Medical School",

year = "2022",

doi = "10.18926/AMO/64043",

language = "English",

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journal = "Acta Medica Okayama",

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T1 - Surgical Resection for Local and Lateral Lymph Node Recurrence of MSI-high Cecal Cancer with the BRAF V600E Mutation

AU - Teraishi, Fuminori

AU - Jikuhara, Atsushi

AU - Ogawa, Ryunosuke

AU - Fujiwara, Toshiyoshi

N1 - Funding Information: We would like to express our deepest gratitude to Dr. Kayoko Iwatani, of the Department of Pathology, Fukuyama Medical Association, for her guidance on histopathological diagnosis in completing this article. Publisher Copyright: © 2022 by Okayama University Medical School

PY - 2022

Y1 - 2022

N2 - An 84-year-old female underwent open right hemicolectomy with D3 lymph node dissection for cecal cancer, pathologically identified as pT4aN2M0 Stage IIIc and BRAF mutation-positive. Due to early recurrence of abdominal wall and right lateral lymph nodes, the patient was treated with FOLFOXIRI+Bevacizumab. Imaging after 5 courses of chemotherapy found tumor shrinkage and no new metastases. The patient did not tolerate chemotherapy well, and tumor resection was performed. Microsatellite instability (MSI) testing using multiplex polymerase chain reaction (PCR) fragment analysis revealed MSI-high status. The patient is currently recurrence-free without chemotherapy at 1 year postoperatively. BRAF-mutated colorectal cancer has a poor prognosis, and may require resection of the metastatic or recurrent tumor after comprehensive evaluation.

AB - An 84-year-old female underwent open right hemicolectomy with D3 lymph node dissection for cecal cancer, pathologically identified as pT4aN2M0 Stage IIIc and BRAF mutation-positive. Due to early recurrence of abdominal wall and right lateral lymph nodes, the patient was treated with FOLFOXIRI+Bevacizumab. Imaging after 5 courses of chemotherapy found tumor shrinkage and no new metastases. The patient did not tolerate chemotherapy well, and tumor resection was performed. Microsatellite instability (MSI) testing using multiplex polymerase chain reaction (PCR) fragment analysis revealed MSI-high status. The patient is currently recurrence-free without chemotherapy at 1 year postoperatively. BRAF-mutated colorectal cancer has a poor prognosis, and may require resection of the metastatic or recurrent tumor after comprehensive evaluation.

KW - Braf v600e mutation

KW - Cecal cancer

KW - Msi-high

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Surgical Resection for Local and Lateral Lymph Node Recurrence of MSI-high Cecal Cancer with the BRAF V600E Mutation

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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