Surgical outcomes for pulmonary metastases from hepatocellular carcinoma

Masafumi Kawamura, Jun Nakajima, Haruhisa Matsuguma, Hirotoshi Horio, Shinichiro Miyoshi, Ken Nakagawa, Takehiko Fujisawa, Koichi Kobayashi

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34 Citations (Scopus)

Abstract

Background: Although favourable prognosis following aggressive treatment of extrahepatic metastases from hepatocellular carcinoma (HCC) has been reported, surgical outcomes for pulmonary metastases are unclear. Methods and materials: Sixty-one patients (2.6%) of 2297 registered with the Metastatic Lung Tumor Study Group of Japan between 1990 and 2006, who underwent surgery for pulmonary metastases from HCC, were retrospectively reviewed from the registry. Results: The overall 5-year survival rate was 32.2%. The prognosis was significantly better for ≤2 lesions than for ≥3 lesions (p = 0.046), for ≤3 lesions than for ≥4 lesions (p = 0.0070), and for ≤4 lesions than for ≥5 lesions (p = 0.029). No other factors that influence outcomes were identified. A stepwise regression analysis showed three or less pulmonary metastases to be an independent factor for better prognosis (p = 0.048). Conclusion: With careful patient selection, comparatively good outcomes can be expected following surgical resection of pulmonary HCC metastases. Among them, patients with multiple metastases, if number of metastases is small such as four or less, can be expected to survive long after surgery.

Original languageEnglish
Pages (from-to)196-199
Number of pages4
JournalEuropean Journal of Cardio-Thoracic Surgery
Volume34
Issue number1
DOIs
Publication statusPublished - Jul 1 2008

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Keywords

  • Extrahepatic metastasis
  • Hepatocellular carcinoma
  • Metastasectomy
  • Pulmonary metastasis
  • Surgery

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Kawamura, M., Nakajima, J., Matsuguma, H., Horio, H., Miyoshi, S., Nakagawa, K., Fujisawa, T., & Kobayashi, K. (2008). Surgical outcomes for pulmonary metastases from hepatocellular carcinoma. European Journal of Cardio-Thoracic Surgery, 34(1), 196-199. https://doi.org/10.1016/j.ejcts.2008.03.056