Surgical Management in Patients with Gastrointestinal Stromal Tumors

A Single-Center Experience

Teppei Tokumaru, Takehiro Okabayashi, Yasuo Shima, Yuichi Shibuya, Kazuhide Ozaki, Tatsuaki Sumiyoshi, Akihito Kozuki, Fuminori Teranishi, Toshio Nakamura, Manabu Matsumoto, Jun Iwata, Sojiro Morita, Tatsuo Iiyama

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: We have revisited prognostic outcomes and recurrence patterns in patients with gastrointestinal stromal tumors (GISTs) who underwent complete surgical resection at a single institution. Patients and Methods: Patients who underwent curative surgical treatment were divided into two groups: those with high-risk GISTs (high-risk group) and those with very low-, low-, and intermediate-risk GISTs (lower-risk group). Results: A total of 109 patients who underwent surgery as an initial treatment for GIST were studied. The overall 5- and 10-year survival rates after surgery were 90.3 and 71.1%, respectively. The 5-year survival rate in high-risk group patients was 88.1%, and their overall survival rate did not vary significantly from that of the lower-risk group (5-year survival rate, 91.3%). The recurrence rate in patients with high-risk GISTs gradually increased without reaching a plateau, with a cumulative rate of GIST recurrence of 26.4 and 48.9% at 5 and 10 years after surgical treatment, respectively. Conclusions: Our data suggest that the repeat surgical management in metastatic GIST is of clinical usefulness whatever the risk and improves survival.

Original languageEnglish
Pages (from-to)273-279
Number of pages7
JournalOncology (Switzerland)
Volume90
Issue number5
DOIs
Publication statusPublished - May 1 2016
Externally publishedYes

Fingerprint

Gastrointestinal Stromal Tumors
Survival Rate
Recurrence
Therapeutics
Survival

Keywords

  • Gastrointestinal stromal tumor
  • Imatinib
  • Outcome
  • Prognosis
  • Surgery

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Tokumaru, T., Okabayashi, T., Shima, Y., Shibuya, Y., Ozaki, K., Sumiyoshi, T., ... Iiyama, T. (2016). Surgical Management in Patients with Gastrointestinal Stromal Tumors: A Single-Center Experience. Oncology (Switzerland), 90(5), 273-279. https://doi.org/10.1159/000445208

Surgical Management in Patients with Gastrointestinal Stromal Tumors : A Single-Center Experience. / Tokumaru, Teppei; Okabayashi, Takehiro; Shima, Yasuo; Shibuya, Yuichi; Ozaki, Kazuhide; Sumiyoshi, Tatsuaki; Kozuki, Akihito; Teranishi, Fuminori; Nakamura, Toshio; Matsumoto, Manabu; Iwata, Jun; Morita, Sojiro; Iiyama, Tatsuo.

In: Oncology (Switzerland), Vol. 90, No. 5, 01.05.2016, p. 273-279.

Research output: Contribution to journalArticle

Tokumaru, T, Okabayashi, T, Shima, Y, Shibuya, Y, Ozaki, K, Sumiyoshi, T, Kozuki, A, Teranishi, F, Nakamura, T, Matsumoto, M, Iwata, J, Morita, S & Iiyama, T 2016, 'Surgical Management in Patients with Gastrointestinal Stromal Tumors: A Single-Center Experience', Oncology (Switzerland), vol. 90, no. 5, pp. 273-279. https://doi.org/10.1159/000445208
Tokumaru T, Okabayashi T, Shima Y, Shibuya Y, Ozaki K, Sumiyoshi T et al. Surgical Management in Patients with Gastrointestinal Stromal Tumors: A Single-Center Experience. Oncology (Switzerland). 2016 May 1;90(5):273-279. https://doi.org/10.1159/000445208
Tokumaru, Teppei ; Okabayashi, Takehiro ; Shima, Yasuo ; Shibuya, Yuichi ; Ozaki, Kazuhide ; Sumiyoshi, Tatsuaki ; Kozuki, Akihito ; Teranishi, Fuminori ; Nakamura, Toshio ; Matsumoto, Manabu ; Iwata, Jun ; Morita, Sojiro ; Iiyama, Tatsuo. / Surgical Management in Patients with Gastrointestinal Stromal Tumors : A Single-Center Experience. In: Oncology (Switzerland). 2016 ; Vol. 90, No. 5. pp. 273-279.
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