Surface topography designed to provide osteoconductivity to titanium after thermal oxidation

Atsushi Sugino, Keita Uetsuki, Kanji Tsuru, Satoshi Hayakawa, Akiyoshi Osaka, Chikara Ohtsuki

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Hydroxyapatite formation on the surface of materials in the body is an essential condition for demonstrating osteoconduction after implantation in bony defects. This paper reports a technique for providing hydroxyapatite formation properties to titanium metals by using specially designed surface topography followed by thermal oxidation. Two pieces of titanium thermally oxidized at 400°C were set together in a V-shape with varied mouth opening. They showed the formation of hydroxyapatite on both facing surfaces after exposure to a simulated body fluid (SBF), when the gap height was approximately less than 600 μm. Moreover, pure titanium specimens with macro-grooves less than 1000 μm in depth and 800 μm in width were able to form hydroxyapatite deposits in SBF within 604.8 ks, after they were thermally oxidized at 400°C for 3.6 ks. Hydroxyapatite also formed on the internal surfaces of macro-grooves made in Ti-15-Zr-4Ta-4Nb within 604.8 ks of soaking in SBF, after the sample was thermally oxidized at 500°C for 3.6 ks, whereas it was not deposited on alloy made of TÍ-6A1-4V extra low interstitial processed in the same way. These findings indicate that titanium and its alloys can be conferred with hydroxyapatite-forming ability, i.e. osteoconduction, within a controlled spatial gap and thermal oxidation. We conclude that bioactive titanium substrate showing osteoconduction can be produced by using a specially designed surface topography followed by thermal oxidation at an appropriate temperature.

Original languageEnglish
Pages (from-to)428-434
Number of pages7
JournalMaterials Transactions
Volume49
Issue number3
DOIs
Publication statusPublished - Mar 2008

Fingerprint

Surface topography
Durapatite
Titanium
Hydroxyapatite
topography
titanium
body fluids
Oxidation
oxidation
Body fluids
grooves
Macros
soaking
mouth
titanium alloys
activity (biology)
implantation
Titanium alloys
interstitials
deposits

Keywords

  • Designed surface topography
  • Hydroxyapatite
  • Macro-groove
  • Thermal oxidation
  • Titanium

ASJC Scopus subject areas

  • Materials Science(all)
  • Metals and Alloys

Cite this

Surface topography designed to provide osteoconductivity to titanium after thermal oxidation. / Sugino, Atsushi; Uetsuki, Keita; Tsuru, Kanji; Hayakawa, Satoshi; Osaka, Akiyoshi; Ohtsuki, Chikara.

In: Materials Transactions, Vol. 49, No. 3, 03.2008, p. 428-434.

Research output: Contribution to journalArticle

Sugino, Atsushi ; Uetsuki, Keita ; Tsuru, Kanji ; Hayakawa, Satoshi ; Osaka, Akiyoshi ; Ohtsuki, Chikara. / Surface topography designed to provide osteoconductivity to titanium after thermal oxidation. In: Materials Transactions. 2008 ; Vol. 49, No. 3. pp. 428-434.
@article{81475e58d7c34be38e0a4034c5fe160d,
title = "Surface topography designed to provide osteoconductivity to titanium after thermal oxidation",
abstract = "Hydroxyapatite formation on the surface of materials in the body is an essential condition for demonstrating osteoconduction after implantation in bony defects. This paper reports a technique for providing hydroxyapatite formation properties to titanium metals by using specially designed surface topography followed by thermal oxidation. Two pieces of titanium thermally oxidized at 400°C were set together in a V-shape with varied mouth opening. They showed the formation of hydroxyapatite on both facing surfaces after exposure to a simulated body fluid (SBF), when the gap height was approximately less than 600 μm. Moreover, pure titanium specimens with macro-grooves less than 1000 μm in depth and 800 μm in width were able to form hydroxyapatite deposits in SBF within 604.8 ks, after they were thermally oxidized at 400°C for 3.6 ks. Hydroxyapatite also formed on the internal surfaces of macro-grooves made in Ti-15-Zr-4Ta-4Nb within 604.8 ks of soaking in SBF, after the sample was thermally oxidized at 500°C for 3.6 ks, whereas it was not deposited on alloy made of T{\'I}-6A1-4V extra low interstitial processed in the same way. These findings indicate that titanium and its alloys can be conferred with hydroxyapatite-forming ability, i.e. osteoconduction, within a controlled spatial gap and thermal oxidation. We conclude that bioactive titanium substrate showing osteoconduction can be produced by using a specially designed surface topography followed by thermal oxidation at an appropriate temperature.",
keywords = "Designed surface topography, Hydroxyapatite, Macro-groove, Thermal oxidation, Titanium",
author = "Atsushi Sugino and Keita Uetsuki and Kanji Tsuru and Satoshi Hayakawa and Akiyoshi Osaka and Chikara Ohtsuki",
year = "2008",
month = "3",
doi = "10.2320/matertrans.MBW200711",
language = "English",
volume = "49",
pages = "428--434",
journal = "Materials Transactions",
issn = "1345-9678",
publisher = "Japan Institute of Metals (JIM)",
number = "3",

}

TY - JOUR

T1 - Surface topography designed to provide osteoconductivity to titanium after thermal oxidation

AU - Sugino, Atsushi

AU - Uetsuki, Keita

AU - Tsuru, Kanji

AU - Hayakawa, Satoshi

AU - Osaka, Akiyoshi

AU - Ohtsuki, Chikara

PY - 2008/3

Y1 - 2008/3

N2 - Hydroxyapatite formation on the surface of materials in the body is an essential condition for demonstrating osteoconduction after implantation in bony defects. This paper reports a technique for providing hydroxyapatite formation properties to titanium metals by using specially designed surface topography followed by thermal oxidation. Two pieces of titanium thermally oxidized at 400°C were set together in a V-shape with varied mouth opening. They showed the formation of hydroxyapatite on both facing surfaces after exposure to a simulated body fluid (SBF), when the gap height was approximately less than 600 μm. Moreover, pure titanium specimens with macro-grooves less than 1000 μm in depth and 800 μm in width were able to form hydroxyapatite deposits in SBF within 604.8 ks, after they were thermally oxidized at 400°C for 3.6 ks. Hydroxyapatite also formed on the internal surfaces of macro-grooves made in Ti-15-Zr-4Ta-4Nb within 604.8 ks of soaking in SBF, after the sample was thermally oxidized at 500°C for 3.6 ks, whereas it was not deposited on alloy made of TÍ-6A1-4V extra low interstitial processed in the same way. These findings indicate that titanium and its alloys can be conferred with hydroxyapatite-forming ability, i.e. osteoconduction, within a controlled spatial gap and thermal oxidation. We conclude that bioactive titanium substrate showing osteoconduction can be produced by using a specially designed surface topography followed by thermal oxidation at an appropriate temperature.

AB - Hydroxyapatite formation on the surface of materials in the body is an essential condition for demonstrating osteoconduction after implantation in bony defects. This paper reports a technique for providing hydroxyapatite formation properties to titanium metals by using specially designed surface topography followed by thermal oxidation. Two pieces of titanium thermally oxidized at 400°C were set together in a V-shape with varied mouth opening. They showed the formation of hydroxyapatite on both facing surfaces after exposure to a simulated body fluid (SBF), when the gap height was approximately less than 600 μm. Moreover, pure titanium specimens with macro-grooves less than 1000 μm in depth and 800 μm in width were able to form hydroxyapatite deposits in SBF within 604.8 ks, after they were thermally oxidized at 400°C for 3.6 ks. Hydroxyapatite also formed on the internal surfaces of macro-grooves made in Ti-15-Zr-4Ta-4Nb within 604.8 ks of soaking in SBF, after the sample was thermally oxidized at 500°C for 3.6 ks, whereas it was not deposited on alloy made of TÍ-6A1-4V extra low interstitial processed in the same way. These findings indicate that titanium and its alloys can be conferred with hydroxyapatite-forming ability, i.e. osteoconduction, within a controlled spatial gap and thermal oxidation. We conclude that bioactive titanium substrate showing osteoconduction can be produced by using a specially designed surface topography followed by thermal oxidation at an appropriate temperature.

KW - Designed surface topography

KW - Hydroxyapatite

KW - Macro-groove

KW - Thermal oxidation

KW - Titanium

UR - http://www.scopus.com/inward/record.url?scp=42349111106&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=42349111106&partnerID=8YFLogxK

U2 - 10.2320/matertrans.MBW200711

DO - 10.2320/matertrans.MBW200711

M3 - Article

AN - SCOPUS:42349111106

VL - 49

SP - 428

EP - 434

JO - Materials Transactions

JF - Materials Transactions

SN - 1345-9678

IS - 3

ER -