Suppressive effects of mometasone furoate on an antigen-specific IgE antibody response and production of IL-4 in mice

Masaki Magari; Mika Ikeda; Miki Asakura; Naoki Kanayama; Masami Ogawa; Hitoshi Ohmori

doi:10.1080/08923970600928155

Suppressive effects of mometasone furoate on an antigen-specific IgE antibody response and production of IL-4 in mice

Masaki Magari, Mika Ikeda, Miki Asakura, Naoki Kanayama, Masami Ogawa, Hitoshi Ohmori

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

A nasal formulation of mometasone furoate (MF) is advantageous in avoiding systemic activity characteristic of glucocorticoids when it is applied topically. To confirm antiallergic effects of this glucocorticoid formulation elaborately, we investigated whether the drug can suppress the production of IgE antibodies and related cytokines. It we showed that IgE production induced in mice immunized via intranasal route was significantly reduced when the mice were administered MF intranasally. Further, MF was effective in inhibiting production of type-2 helper T cell cytokines in vivo and in vitro. These results provide a immunopharmacological basis for clinical efficacy of this drug.

Original language	English
Pages (from-to)	491-500
Number of pages	10
Journal	Immunopharmacology and Immunotoxicology
Volume	28
Issue number	3
DOIs	https://doi.org/10.1080/08923970600928155
Publication status	Published - Sep 1 2006

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Toxicology
Pharmacology

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abstract = "A nasal formulation of mometasone furoate (MF) is advantageous in avoiding systemic activity characteristic of glucocorticoids when it is applied topically. To confirm antiallergic effects of this glucocorticoid formulation elaborately, we investigated whether the drug can suppress the production of IgE antibodies and related cytokines. It we showed that IgE production induced in mice immunized via intranasal route was significantly reduced when the mice were administered MF intranasally. Further, MF was effective in inhibiting production of type-2 helper T cell cytokines in vivo and in vitro. These results provide a immunopharmacological basis for clinical efficacy of this drug.",

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AU - Ogawa, Masami

AU - Ohmori, Hitoshi

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