Suppressive effects of mometasone furoate on an antigen-specific IgE antibody response and production of IL-4 in mice

Masaki Magari, Mika Ikeda, Miki Asakura, Naoki Kanayama, Masami Ogawa, Hitoshi Ohmori

Research output: Contribution to journalArticle

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Abstract

A nasal formulation of mometasone furoate (MF) is advantageous in avoiding systemic activity characteristic of glucocorticoids when it is applied topically. To confirm antiallergic effects of this glucocorticoid formulation elaborately, we investigated whether the drug can suppress the production of IgE antibodies and related cytokines. It we showed that IgE production induced in mice immunized via intranasal route was significantly reduced when the mice were administered MF intranasally. Further, MF was effective in inhibiting production of type-2 helper T cell cytokines in vivo and in vitro. These results provide a immunopharmacological basis for clinical efficacy of this drug.

Original languageEnglish
Pages (from-to)491-500
Number of pages10
JournalImmunopharmacology and Immunotoxicology
Volume28
Issue number3
DOIs
Publication statusPublished - Sep 1 2006

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Mometasone Furoate
Interleukin-4
Immunoglobulin E
Antibody Formation
Antigens
Glucocorticoids
Antibodies
Cytokines
Anti-Allergic Agents
Th2 Cells
T-cells
Nose
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Immunology
  • Pharmacology
  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Suppressive effects of mometasone furoate on an antigen-specific IgE antibody response and production of IL-4 in mice. / Magari, Masaki; Ikeda, Mika; Asakura, Miki; Kanayama, Naoki; Ogawa, Masami; Ohmori, Hitoshi.

In: Immunopharmacology and Immunotoxicology, Vol. 28, No. 3, 01.09.2006, p. 491-500.

Research output: Contribution to journalArticle

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