Suppressive effect of overexpressed connective tissue growth factor on tumor cell growth in a human oral squamous cell carcinoma-derived cell line

Norifumi H. Moritani, Satoshi Kubota, Takashi Nishida, Harumi Kawaki, Seiji Kondo, Toshio Sugahara, Masaharu Takigawa

Research output: Contribution to journalArticlepeer-review

49 Citations (Scopus)

Abstract

Connective tissue growth factor (CTGF) is known to be a multifunctional growth factor that is overexpressed in several types of malignancies. In this study, effects of CTGF gene overexpression on the phenotypes of oral squamous cell carcinoma cells were investigated by using a cell line with undetectable endogenous CTGF expression. Surprisingly, our results indicated that CTGF-overexpressed clones were characterized by attenuated cell growth and less potent tumorigenicity, with coincidental downregulation of prothymosin α gene. Although CTGF is known to promote cell proliferation in mesenchymal cells, our present results suggest that CTGF acts as a negative regulator of the cell growth in oral squamous cell carcinoma possibly through its interaction with growth modifiers inside the cell.

Original languageEnglish
Pages (from-to)205-214
Number of pages10
JournalCancer Letters
Volume192
Issue number2
DOIs
Publication statusPublished - Mar 31 2003

Keywords

  • Connective tissue growth factor
  • Negative regulator
  • Oral squamous cell carcinoma
  • Prothymosin alpha

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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