Suppressive Effect of a Neutrophil Elastase Inhibitor on the Development of Collagen-Induced Arthritis

Kiichi Kakimoto, Akihiro Matsukawa, Masaru Yoshinaga, Hiroshi Nakamura

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

A novel neutrophil elastase inhibitor, ONO-5046, was administered to BB/DR rats and DBA/1 mice immunized with type II collagen to study its effect on the development of collagen-induced arthritis (CA), an experimental model of human rheumatoid arthritis. ONO-5046 reduced the incidence as well as the severity of CA in both rats and mice. This suppressive effect on severity was correlated with improvement of the histological findings, particularly with reduced destruction of the articular cartilage. These results indicate that neutrophil elastase may play an important role in the pathogenesis of CA.

Original languageEnglish
Pages (from-to)26-32
Number of pages7
JournalCellular Immunology
Volume165
Issue number1
DOIs
Publication statusPublished - Oct 1 1995
Externally publishedYes

Fingerprint

Secretory Proteinase Inhibitory Proteins
Experimental Arthritis
Inbred BB Rats
Leukocyte Elastase
Inbred DBA Mouse
Collagen Type II
Articular Cartilage
Rheumatoid Arthritis
Theoretical Models
Incidence
sivelestat

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

Cite this

Suppressive Effect of a Neutrophil Elastase Inhibitor on the Development of Collagen-Induced Arthritis. / Kakimoto, Kiichi; Matsukawa, Akihiro; Yoshinaga, Masaru; Nakamura, Hiroshi.

In: Cellular Immunology, Vol. 165, No. 1, 01.10.1995, p. 26-32.

Research output: Contribution to journalArticle

Kakimoto, Kiichi ; Matsukawa, Akihiro ; Yoshinaga, Masaru ; Nakamura, Hiroshi. / Suppressive Effect of a Neutrophil Elastase Inhibitor on the Development of Collagen-Induced Arthritis. In: Cellular Immunology. 1995 ; Vol. 165, No. 1. pp. 26-32.
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