Suppression of tumor metastasis by manganese superoxide dismutase is associated with reduced tumorigenicity and elevated fibronectin

Daret K. St. Clair, X. Steven Wan, Masahiro Kuroda, Satit Vichitbandha, Emiko Tsuchida, Muneyasu Urano

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

We have examined the tumorigenicity and the level of extracellular matrix proteins in fibrosarcoma cells expressing low (SOD-L) and high (SOD- H) MnSOD activities as well as the fibrosarcoma cells transfected with the selectable marker alone (NEO). When the cells derived from each tumor cell line were injected into syngeneic mice, the number of tumor cells required to make a tumor in one-half of the mice (TD50) was markedly increased in MnSOD-transfected cells. The decrease in the tumorigenicity of the MnSOD- transfected cells was associated with an increase in the fibronectin level. These results support the hypothesis that MnSOD is a new type of tumor- suppressor gene.

Original languageEnglish
Pages (from-to)753-757
Number of pages5
JournalOncology reports
Volume4
Issue number4
DOIs
Publication statusPublished - 1997

Keywords

  • Fibronectin
  • MnSOD
  • Tumor metastasis
  • Tumor suppressor
  • Tumorigenicity

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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