Suppression of streptozotocin-induced type-1 diabetes in mice by radon inhalation

Y. Nishiyama, Takahiro Kataoka, J. Teraoka, A. Sakoda, H. Tanaka, Y. Ishimori, Fumihiro Mitsunobu, Takehito Taguchi, Kiyonori Yamaoka

Research output: Contribution to journalArticle

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Abstract

We examined the protective effect of radon inhalation on streptozotocin (STZ)-induced type-1 diabetes in mice. Mice inhaled radon at concentrations of 1000, 2500, and 5500 Bq/m3 for 24 hours before STZ administration. STZ administration induced characteristics of type-1 diabetes such as hyperglycemia and hypoinsulinemia; however, radon inhalation at doses of 1000 and 5500 Bq/m3 significantly suppressed the elevation of blood glucose in diabetic mice. Serum insulin was significantly higher in mice pre-treated with radon at a dose of 1000 Bq/m3 than in mice treated with a sham. In addition, superoxide dismutase activities and total glutathione contents were significantly higher and lipid peroxide was significantly lower in mice pre-treated with radon at doses of 1000 and 5500 Bq/m3 than in mice treated with a sham. These results were consistent with the result that radon inhalation at 1000 and 5500 Bq/m3 suppressed hyperglycemia. These findings suggested that radon inhalation suppressed STZ-induced type-1 diabetes through the enhancement of antioxidative functions in the pancreas.

Original languageEnglish
Pages (from-to)57-66
Number of pages10
JournalPhysiological Research
Volume62
Issue number1
Publication statusPublished - 2013

Fingerprint

Radon
Streptozocin
Type 1 Diabetes Mellitus
Inhalation
Hyperglycemia
Lipid Peroxides
Superoxide Dismutase
Glutathione
Blood Glucose
Pancreas
Insulin
Serum

Keywords

  • Antioxidative function
  • Radon inhalation
  • Streptozotocin
  • Type-1 diabetes

ASJC Scopus subject areas

  • Physiology

Cite this

Nishiyama, Y., Kataoka, T., Teraoka, J., Sakoda, A., Tanaka, H., Ishimori, Y., ... Yamaoka, K. (2013). Suppression of streptozotocin-induced type-1 diabetes in mice by radon inhalation. Physiological Research, 62(1), 57-66.

Suppression of streptozotocin-induced type-1 diabetes in mice by radon inhalation. / Nishiyama, Y.; Kataoka, Takahiro; Teraoka, J.; Sakoda, A.; Tanaka, H.; Ishimori, Y.; Mitsunobu, Fumihiro; Taguchi, Takehito; Yamaoka, Kiyonori.

In: Physiological Research, Vol. 62, No. 1, 2013, p. 57-66.

Research output: Contribution to journalArticle

Nishiyama Y, Kataoka T, Teraoka J, Sakoda A, Tanaka H, Ishimori Y et al. Suppression of streptozotocin-induced type-1 diabetes in mice by radon inhalation. Physiological Research. 2013;62(1):57-66.
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