Suppression of postoperative liver metastases from colon cancer by continuous intraportal infusion of an angiogenesis inhibitor FR-118487

I. Eda, H. Soga, M. Ueoka, K. Yamashita, S. Kawasaki, Hiroyoshi Doihara, R. Hirai, N. Shimizu

Research output: Contribution to journalArticle

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Abstract

A rabbit VX2 colon cancer model with spontaneous liver metastases was used to evaluate the antitumor effect of an angiogenesis inhibitor, FR-118487. FR- 118487 (1 mg/kg/day) was infused continuously into the portal vein for a week after resection of primary colon cancer lesions (FR group). The incidence of liver metastases was 71.4% (5/7) in FR group, and 100% (7/7) in control group. The numher and the weight of liver metastatic nodules were 31.0±36.0 and 1.4±1.8 g in FR group versus 83.7±73.9 and 6.5±4.9 g in control group, respectively. The metastases in FR group were significantly decreased in weight compared with those in control group (p

Original languageEnglish
Pages (from-to)1480-1482
Number of pages3
JournalGan to kagaku ryoho. Cancer & chemotherapy
Volume22
Issue number11
Publication statusPublished - 1995

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Angiogenesis Inhibitors
Colonic Neoplasms
Neoplasm Metastasis
Control Groups
Liver
Weights and Measures
Portal Vein
Rabbits
Incidence
FR 118487

Keywords

  • Colon cancer
  • Continuous intraportal infusion
  • FR-118487
  • Liver metastasis

ASJC Scopus subject areas

  • Cancer Research
  • Pharmacology

Cite this

Suppression of postoperative liver metastases from colon cancer by continuous intraportal infusion of an angiogenesis inhibitor FR-118487. / Eda, I.; Soga, H.; Ueoka, M.; Yamashita, K.; Kawasaki, S.; Doihara, Hiroyoshi; Hirai, R.; Shimizu, N.

In: Gan to kagaku ryoho. Cancer & chemotherapy, Vol. 22, No. 11, 1995, p. 1480-1482.

Research output: Contribution to journalArticle

Eda, I. ; Soga, H. ; Ueoka, M. ; Yamashita, K. ; Kawasaki, S. ; Doihara, Hiroyoshi ; Hirai, R. ; Shimizu, N. / Suppression of postoperative liver metastases from colon cancer by continuous intraportal infusion of an angiogenesis inhibitor FR-118487. In: Gan to kagaku ryoho. Cancer & chemotherapy. 1995 ; Vol. 22, No. 11. pp. 1480-1482.
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AU - Soga, H.

AU - Ueoka, M.

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AU - Kawasaki, S.

AU - Doihara, Hiroyoshi

AU - Hirai, R.

AU - Shimizu, N.

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