Suppression of AP-1 activity by cycloprodigiosin hydrochloride

Keiko Kawauchi, Kei Tobiume, Shuhei Kaneko, Keiko Kaneshiro, Shiho Okamoto, Emi Ueda, Hideaki Kamata, Yoshinori Moriyama, Hajime Hirata

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Cycloprodigiosin hydrochloride (cPrG · HCl), a compound isolated from a marine bacterium, acts as an immunosuppressant and an anti-cancer drug. We have previously reported that cPrG · HCl suppressed the transcriptional activation of nuclear factor (NF)-κB. Here we studied the effect of cPrG · HCl on activation of another transcription factor, activator protein 1 (AP-1). cPrG · HCl potently suppressed AP-1 activity induced by tumor necrosis factor (TNF) α and phorbol myristate acetate (PMA). cPrG · HCl did not inhibit any of the mitogen-activated protein kinase (MAPK) families, whereas it did suppress transcriptional activation of AP-1 induced by constitutively activated mutants of MEKK1 or Ras. cPrG · HCl inhibited neither TNFα- or PMA-induced DNA-binding of AP-1 nor co-activator p300-induced activation of AP-1. Taken together, cPrG · HCl suppresses AP-1-dependent gene expression downstream of MAPK group through the inhibition of the transcription activation step of the AP-1 promoter complex.

Original languageEnglish
Pages (from-to)1792-1795
Number of pages4
JournalBiological and Pharmaceutical Bulletin
Volume30
Issue number9
DOIs
Publication statusPublished - Sep 2007

Fingerprint

Transcription Factor AP-1
Transcriptional Activation
Tetradecanoylphorbol Acetate
Mitogen-Activated Protein Kinases
Tumor Necrosis Factor-alpha
DNA-Binding Proteins
Immunosuppressive Agents
cycloprodigiosin
Transcription Factors
Bacteria
Gene Expression
Pharmaceutical Preparations
Neoplasms

Keywords

  • Activator protein 1
  • Mitogen-activated protein kinase
  • Nuclear factor (NF)-κB
  • Prodigiosin

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Kawauchi, K., Tobiume, K., Kaneko, S., Kaneshiro, K., Okamoto, S., Ueda, E., ... Hirata, H. (2007). Suppression of AP-1 activity by cycloprodigiosin hydrochloride. Biological and Pharmaceutical Bulletin, 30(9), 1792-1795. https://doi.org/10.1248/bpb.30.1792

Suppression of AP-1 activity by cycloprodigiosin hydrochloride. / Kawauchi, Keiko; Tobiume, Kei; Kaneko, Shuhei; Kaneshiro, Keiko; Okamoto, Shiho; Ueda, Emi; Kamata, Hideaki; Moriyama, Yoshinori; Hirata, Hajime.

In: Biological and Pharmaceutical Bulletin, Vol. 30, No. 9, 09.2007, p. 1792-1795.

Research output: Contribution to journalArticle

Kawauchi, K, Tobiume, K, Kaneko, S, Kaneshiro, K, Okamoto, S, Ueda, E, Kamata, H, Moriyama, Y & Hirata, H 2007, 'Suppression of AP-1 activity by cycloprodigiosin hydrochloride', Biological and Pharmaceutical Bulletin, vol. 30, no. 9, pp. 1792-1795. https://doi.org/10.1248/bpb.30.1792
Kawauchi K, Tobiume K, Kaneko S, Kaneshiro K, Okamoto S, Ueda E et al. Suppression of AP-1 activity by cycloprodigiosin hydrochloride. Biological and Pharmaceutical Bulletin. 2007 Sep;30(9):1792-1795. https://doi.org/10.1248/bpb.30.1792
Kawauchi, Keiko ; Tobiume, Kei ; Kaneko, Shuhei ; Kaneshiro, Keiko ; Okamoto, Shiho ; Ueda, Emi ; Kamata, Hideaki ; Moriyama, Yoshinori ; Hirata, Hajime. / Suppression of AP-1 activity by cycloprodigiosin hydrochloride. In: Biological and Pharmaceutical Bulletin. 2007 ; Vol. 30, No. 9. pp. 1792-1795.
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