Suppression of allergic inflammation by the prostaglandin E receptor subtype EP3

Tomonori Kunikata, Hana Yamane, Eri Segi, Toshiyuki Matsuoka, Yukihiko Sugimoto, Satoshi Tanaka, Hiroyuki Tanaka, Hiroichi Nagai, Atsushi Ichikawa, Shuh Narumiya

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171 Citations (Scopus)

Abstract

Prostaglandins, including PGD2 and PGE2, are produced during allergic reactions. Although PGD2 is an important mediator of allergic responses, aspirin-like drugs that inhibit prostaglandin synthesis are generally ineffective in allergic disorders, suggesting that another prostaglandin-mediated pathway prevents the development of allergic reactions. Here we show that such a pathway may be mediated by PGE2 acting at the prostaglandin E receptor EP3. Mice lacking EP3 developed allergic inflammation that was much more pronounced than that in wild-type mice or mice deficient in other prostaglandin E receptor subtypes. Conversely, an EP3-selective agonist suppressed the inflammation. This suppression was effective when the agonist was administered 3 h after antigen challenge and was associated with inhibition of allergy-related gene expression. Thus, the PGE2-EPB pathway is an important negative modulator of allergic reactions.

Original languageEnglish
Pages (from-to)524-531
Number of pages8
JournalNature Immunology
Volume6
Issue number5
DOIs
Publication statusPublished - 2005
Externally publishedYes

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ASJC Scopus subject areas

  • Immunology

Cite this

Kunikata, T., Yamane, H., Segi, E., Matsuoka, T., Sugimoto, Y., Tanaka, S., Tanaka, H., Nagai, H., Ichikawa, A., & Narumiya, S. (2005). Suppression of allergic inflammation by the prostaglandin E receptor subtype EP3. Nature Immunology, 6(5), 524-531. https://doi.org/10.1038/ni1188