Suppression of allergic inflammation by the prostaglandin E receptor subtype EP3

Tomonori Kunikata, Hana Yamane, Eri Segi, Toshiyuki Matsuoka, Yukihiko Sugimoto, Satoshi Tanaka, Hiroyuki Tanaka, Hiroichi Nagai, Atsushi Ichikawa, Shuh Narumiya

Research output: Contribution to journalArticlepeer-review

190 Citations (Scopus)


Prostaglandins, including PGD2 and PGE2, are produced during allergic reactions. Although PGD2 is an important mediator of allergic responses, aspirin-like drugs that inhibit prostaglandin synthesis are generally ineffective in allergic disorders, suggesting that another prostaglandin-mediated pathway prevents the development of allergic reactions. Here we show that such a pathway may be mediated by PGE2 acting at the prostaglandin E receptor EP3. Mice lacking EP3 developed allergic inflammation that was much more pronounced than that in wild-type mice or mice deficient in other prostaglandin E receptor subtypes. Conversely, an EP3-selective agonist suppressed the inflammation. This suppression was effective when the agonist was administered 3 h after antigen challenge and was associated with inhibition of allergy-related gene expression. Thus, the PGE2-EPB pathway is an important negative modulator of allergic reactions.

Original languageEnglish
Pages (from-to)524-531
Number of pages8
JournalNature Immunology
Issue number5
Publication statusPublished - 2005

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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