Abstract
Prostaglandins, including PGD2 and PGE2, are produced during allergic reactions. Although PGD2 is an important mediator of allergic responses, aspirin-like drugs that inhibit prostaglandin synthesis are generally ineffective in allergic disorders, suggesting that another prostaglandin-mediated pathway prevents the development of allergic reactions. Here we show that such a pathway may be mediated by PGE2 acting at the prostaglandin E receptor EP3. Mice lacking EP3 developed allergic inflammation that was much more pronounced than that in wild-type mice or mice deficient in other prostaglandin E receptor subtypes. Conversely, an EP3-selective agonist suppressed the inflammation. This suppression was effective when the agonist was administered 3 h after antigen challenge and was associated with inhibition of allergy-related gene expression. Thus, the PGE2-EPB pathway is an important negative modulator of allergic reactions.
| Original language | English |
|---|---|
| Pages (from-to) | 524-531 |
| Number of pages | 8 |
| Journal | Nature Immunology |
| Volume | 6 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2005 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Immunology
Cite this
Suppression of allergic inflammation by the prostaglandin E receptor subtype EP3. / Kunikata, Tomonori; Yamane, Hana; Segi, Eri; Matsuoka, Toshiyuki; Sugimoto, Yukihiko; Tanaka, Satoshi; Tanaka, Hiroyuki; Nagai, Hiroichi; Ichikawa, Atsushi; Narumiya, Shuh.
In: Nature Immunology, Vol. 6, No. 5, 2005, p. 524-531.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Suppression of allergic inflammation by the prostaglandin E receptor subtype EP3
AU - Kunikata, Tomonori
AU - Yamane, Hana
AU - Segi, Eri
AU - Matsuoka, Toshiyuki
AU - Sugimoto, Yukihiko
AU - Tanaka, Satoshi
AU - Tanaka, Hiroyuki
AU - Nagai, Hiroichi
AU - Ichikawa, Atsushi
AU - Narumiya, Shuh
PY - 2005
Y1 - 2005
N2 - Prostaglandins, including PGD2 and PGE2, are produced during allergic reactions. Although PGD2 is an important mediator of allergic responses, aspirin-like drugs that inhibit prostaglandin synthesis are generally ineffective in allergic disorders, suggesting that another prostaglandin-mediated pathway prevents the development of allergic reactions. Here we show that such a pathway may be mediated by PGE2 acting at the prostaglandin E receptor EP3. Mice lacking EP3 developed allergic inflammation that was much more pronounced than that in wild-type mice or mice deficient in other prostaglandin E receptor subtypes. Conversely, an EP3-selective agonist suppressed the inflammation. This suppression was effective when the agonist was administered 3 h after antigen challenge and was associated with inhibition of allergy-related gene expression. Thus, the PGE2-EPB pathway is an important negative modulator of allergic reactions.
AB - Prostaglandins, including PGD2 and PGE2, are produced during allergic reactions. Although PGD2 is an important mediator of allergic responses, aspirin-like drugs that inhibit prostaglandin synthesis are generally ineffective in allergic disorders, suggesting that another prostaglandin-mediated pathway prevents the development of allergic reactions. Here we show that such a pathway may be mediated by PGE2 acting at the prostaglandin E receptor EP3. Mice lacking EP3 developed allergic inflammation that was much more pronounced than that in wild-type mice or mice deficient in other prostaglandin E receptor subtypes. Conversely, an EP3-selective agonist suppressed the inflammation. This suppression was effective when the agonist was administered 3 h after antigen challenge and was associated with inhibition of allergy-related gene expression. Thus, the PGE2-EPB pathway is an important negative modulator of allergic reactions.
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UR - http://www.scopus.com/inward/citedby.url?scp=18244406799&partnerID=8YFLogxK
U2 - 10.1038/ni1188
DO - 10.1038/ni1188
M3 - Article
C2 - 15806106
AN - SCOPUS:18244406799
VL - 6
SP - 524
EP - 531
JO - Nature Immunology
JF - Nature Immunology
SN - 1529-2908
IS - 5
ER -