Abstract
Prostaglandins, including PGD2 and PGE2, are produced during allergic reactions. Although PGD2 is an important mediator of allergic responses, aspirin-like drugs that inhibit prostaglandin synthesis are generally ineffective in allergic disorders, suggesting that another prostaglandin-mediated pathway prevents the development of allergic reactions. Here we show that such a pathway may be mediated by PGE2 acting at the prostaglandin E receptor EP3. Mice lacking EP3 developed allergic inflammation that was much more pronounced than that in wild-type mice or mice deficient in other prostaglandin E receptor subtypes. Conversely, an EP3-selective agonist suppressed the inflammation. This suppression was effective when the agonist was administered 3 h after antigen challenge and was associated with inhibition of allergy-related gene expression. Thus, the PGE2-EPB pathway is an important negative modulator of allergic reactions.
Original language | English |
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Pages (from-to) | 524-531 |
Number of pages | 8 |
Journal | Nature Immunology |
Volume | 6 |
Issue number | 5 |
DOIs | |
Publication status | Published - 2005 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology