Abstract
We report on a patient with early-onset spasms in series and partial seizures associated with focal cortical dysplasia whose EEGs showed suppression-burst patterns during early infancy. These electroclinical characteristics suggested a diagnosis of Ohtahara syndrome, but the EEG findings were atypical because of the lack of suppression-burst patterns during wakefulness. In addition, the patient did not have severe psychomotor retardation. With high-dose pyridoxal phosphate therapy, seizures were suppressed and suppression-burst patterns disappeared at 2 months of age. Focal motor seizures recurred later and they often evolved into epilepsia partialis continua. Patients with early-onset intractable seizures associated with suppression-burst patterns on EEGs have several different etiologies, and these patients should be categorized according to their etiology in addition to their syndromic diagnosis. (C) 2000 Elsevier Science B.V.
| Original language | English |
|---|---|
| Pages (from-to) | 135-138 |
| Number of pages | 4 |
| Journal | Brain and Development |
| Volume | 22 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Mar 14 2000 |
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Keywords
- Early-infantile epileptic encephalopathy with suppression bursts
- Focal cortical dysplasia
- Ohtahara syndrome
- Spasms
- Suppression-burst pattern
ASJC Scopus subject areas
- Clinical Neurology
- Pediatrics, Perinatology, and Child Health
- Neurology
Cite this
Suppression-burst patterns in intractable epilepsy with focal cortical dysplasia. / Ohtsuka, Yoko; Sato, Masahiro; Sanada, Satoshi; Yoshinaga, Harumi; Oka, Eiji.
In: Brain and Development, Vol. 22, No. 2, 14.03.2000, p. 135-138.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Suppression-burst patterns in intractable epilepsy with focal cortical dysplasia
AU - Ohtsuka, Yoko
AU - Sato, Masahiro
AU - Sanada, Satoshi
AU - Yoshinaga, Harumi
AU - Oka, Eiji
PY - 2000/3/14
Y1 - 2000/3/14
N2 - We report on a patient with early-onset spasms in series and partial seizures associated with focal cortical dysplasia whose EEGs showed suppression-burst patterns during early infancy. These electroclinical characteristics suggested a diagnosis of Ohtahara syndrome, but the EEG findings were atypical because of the lack of suppression-burst patterns during wakefulness. In addition, the patient did not have severe psychomotor retardation. With high-dose pyridoxal phosphate therapy, seizures were suppressed and suppression-burst patterns disappeared at 2 months of age. Focal motor seizures recurred later and they often evolved into epilepsia partialis continua. Patients with early-onset intractable seizures associated with suppression-burst patterns on EEGs have several different etiologies, and these patients should be categorized according to their etiology in addition to their syndromic diagnosis. (C) 2000 Elsevier Science B.V.
AB - We report on a patient with early-onset spasms in series and partial seizures associated with focal cortical dysplasia whose EEGs showed suppression-burst patterns during early infancy. These electroclinical characteristics suggested a diagnosis of Ohtahara syndrome, but the EEG findings were atypical because of the lack of suppression-burst patterns during wakefulness. In addition, the patient did not have severe psychomotor retardation. With high-dose pyridoxal phosphate therapy, seizures were suppressed and suppression-burst patterns disappeared at 2 months of age. Focal motor seizures recurred later and they often evolved into epilepsia partialis continua. Patients with early-onset intractable seizures associated with suppression-burst patterns on EEGs have several different etiologies, and these patients should be categorized according to their etiology in addition to their syndromic diagnosis. (C) 2000 Elsevier Science B.V.
KW - Early-infantile epileptic encephalopathy with suppression bursts
KW - Focal cortical dysplasia
KW - Ohtahara syndrome
KW - Spasms
KW - Suppression-burst pattern
UR - http://www.scopus.com/inward/record.url?scp=0034646237&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034646237&partnerID=8YFLogxK
U2 - 10.1016/S0387-7604(00)00090-5
DO - 10.1016/S0387-7604(00)00090-5
M3 - Article
C2 - 10722968
AN - SCOPUS:0034646237
VL - 22
SP - 135
EP - 138
JO - Brain and Development
JF - Brain and Development
SN - 0387-7604
IS - 2
ER -