Suppression-burst patterns in intractable epilepsy with focal cortical dysplasia

Yoko Ohtsuka, Masahiro Sato, Satoshi Sanada, Harumi Yoshinaga, Eiji Oka

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

We report on a patient with early-onset spasms in series and partial seizures associated with focal cortical dysplasia whose EEGs showed suppression-burst patterns during early infancy. These electroclinical characteristics suggested a diagnosis of Ohtahara syndrome, but the EEG findings were atypical because of the lack of suppression-burst patterns during wakefulness. In addition, the patient did not have severe psychomotor retardation. With high-dose pyridoxal phosphate therapy, seizures were suppressed and suppression-burst patterns disappeared at 2 months of age. Focal motor seizures recurred later and they often evolved into epilepsia partialis continua. Patients with early-onset intractable seizures associated with suppression-burst patterns on EEGs have several different etiologies, and these patients should be categorized according to their etiology in addition to their syndromic diagnosis. (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)135-138
Number of pages4
JournalBrain and Development
Volume22
Issue number2
DOIs
Publication statusPublished - Mar 14 2000

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Keywords

  • Early-infantile epileptic encephalopathy with suppression bursts
  • Focal cortical dysplasia
  • Ohtahara syndrome
  • Spasms
  • Suppression-burst pattern

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Neurology

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