Suppressed recombination on mouse chromosome 15 defined regions of chromosomal inversions associated with Koala (Koa) and hairy ears (Eh) mutations

Kentaro Katayama, Aki Furuno, Sayaka Miyamoto, Miyuki Nakamura, Izumi Ojika, Yusuke Shinkai, Kouyou Akiyama, Takehito Tsuji, Tetsuo Kunieda

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Koala (Koa) and hairy ears (Eh) mutations of mice are associated with chromosomal inversions in the distal half of chromosome 15. Since these two mutant mice show some common phenotypic features including extra hair on pinna and craniofacial dysmorphogenesis and have similar inverted regions, we determined the inverted regions. of these two chromosomal inversions to examine whether a common gene is responsible for the phenotypes of these two mutants. The inverted regions were identified as the recombination-suppressed regions by linkage analysis. The length of the recombination-suppressed regions of Koa and Eh were approximately 52 and 47 Mb, respectively, and these inverted regions were not the same. These results indicate that the phenotypes of Koa and Eh mutant mice are likely to be caused by different genes.

Original languageEnglish
Pages (from-to)73-77
Number of pages5
JournalExperimental Animals
Issue number1
Publication statusPublished - Mar 18 2008



  • Chromosomal inversion
  • Eh mutation
  • Koa mutation

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Biochemistry, Genetics and Molecular Biology(all)
  • veterinary(all)

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