Successful vancomycin dose adjustment in a sepsis patient with bacterial meningitis using cystatin C

Masayuki Chuma; Masateru Kondo; Yoshito Zamami; Kenshi Takechi; Mitsuhiro Goda; Naoto Okada; Akitomo Shibata; Mizuho Asada; Jun Oto; Hiroaki Yanagawa; Keisuke Ishizawa

Successful vancomycin dose adjustment in a sepsis patient with bacterial meningitis using cystatin C

Masayuki Chuma, Masateru Kondo, Yoshito Zamami, Kenshi Takechi, Mitsuhiro Goda, Naoto Okada, Akitomo Shibata, Mizuho Asada, Jun Oto, Hiroaki Yanagawa, Keisuke Ishizawa

Research output: Contribution to journal › Article › peer-review

Abstract

Cystatin C-guided vancomycin (VCM) dosing is useful in critically ill patients. Its usefulness in septic patients with bacterial meningitis remains unknown, as there are no published reports. In this study, we sought to clarify its benefit. Cystatin C was used to guide VCM dosing in a septic bacterial meningitis patient with normal kidney function, according to therapeutic drug monitoring (TDM). Using cystatin C, the Bayesian method-based TDM made optimal VCM dosing possible, and decreased the predicted error (4.85 mg/L) compared to serum creatinine (16.83 mg/L). We concluded TDM of VCM using cystatin C can be considered in sepsis patients with bacterial meningitis with normal kidney function.

Original language	English
Pages (from-to)	365-370
Number of pages	6
Journal	Acta medica Okayama
Volume	74
Issue number	4
Publication status	Published - 2020
Externally published	Yes

Keywords

Bacterial meningitis
Cystatin C
Sepsis
Therapeutic drug monitoring
Vancomycin

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Cite this

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title = "Successful vancomycin dose adjustment in a sepsis patient with bacterial meningitis using cystatin C",

abstract = "Cystatin C-guided vancomycin (VCM) dosing is useful in critically ill patients. Its usefulness in septic patients with bacterial meningitis remains unknown, as there are no published reports. In this study, we sought to clarify its benefit. Cystatin C was used to guide VCM dosing in a septic bacterial meningitis patient with normal kidney function, according to therapeutic drug monitoring (TDM). Using cystatin C, the Bayesian method-based TDM made optimal VCM dosing possible, and decreased the predicted error (4.85 mg/L) compared to serum creatinine (16.83 mg/L). We concluded TDM of VCM using cystatin C can be considered in sepsis patients with bacterial meningitis with normal kidney function.",

keywords = "Bacterial meningitis, Cystatin C, Sepsis, Therapeutic drug monitoring, Vancomycin",

author = "Masayuki Chuma and Masateru Kondo and Yoshito Zamami and Kenshi Takechi and Mitsuhiro Goda and Naoto Okada and Akitomo Shibata and Mizuho Asada and Jun Oto and Hiroaki Yanagawa and Keisuke Ishizawa",

note = "Funding Information: Acknowledgments.　This study was supported by JSPS KAKENHI [grant number 19K16448]. Publisher Copyright: {\textcopyright} 2020 by Okayama University Medical School.",

year = "2020",

language = "English",

volume = "74",

pages = "365--370",

journal = "Acta Medica Okayama",

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AU - Chuma, Masayuki

AU - Kondo, Masateru

AU - Zamami, Yoshito

AU - Takechi, Kenshi

AU - Goda, Mitsuhiro

AU - Okada, Naoto

AU - Shibata, Akitomo

AU - Asada, Mizuho

AU - Oto, Jun

AU - Yanagawa, Hiroaki

AU - Ishizawa, Keisuke

PY - 2020

Y1 - 2020

N2 - Cystatin C-guided vancomycin (VCM) dosing is useful in critically ill patients. Its usefulness in septic patients with bacterial meningitis remains unknown, as there are no published reports. In this study, we sought to clarify its benefit. Cystatin C was used to guide VCM dosing in a septic bacterial meningitis patient with normal kidney function, according to therapeutic drug monitoring (TDM). Using cystatin C, the Bayesian method-based TDM made optimal VCM dosing possible, and decreased the predicted error (4.85 mg/L) compared to serum creatinine (16.83 mg/L). We concluded TDM of VCM using cystatin C can be considered in sepsis patients with bacterial meningitis with normal kidney function.

AB - Cystatin C-guided vancomycin (VCM) dosing is useful in critically ill patients. Its usefulness in septic patients with bacterial meningitis remains unknown, as there are no published reports. In this study, we sought to clarify its benefit. Cystatin C was used to guide VCM dosing in a septic bacterial meningitis patient with normal kidney function, according to therapeutic drug monitoring (TDM). Using cystatin C, the Bayesian method-based TDM made optimal VCM dosing possible, and decreased the predicted error (4.85 mg/L) compared to serum creatinine (16.83 mg/L). We concluded TDM of VCM using cystatin C can be considered in sepsis patients with bacterial meningitis with normal kidney function.

KW - Bacterial meningitis

KW - Cystatin C

KW - Sepsis

KW - Therapeutic drug monitoring

KW - Vancomycin

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Successful vancomycin dose adjustment in a sepsis patient with bacterial meningitis using cystatin C

Abstract

Keywords

ASJC Scopus subject areas

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