Successful treatment with corticosteroids for refractory deterioration of cryptococcal meningitis with an increasing cryptococcal antigen titer

Yoshiaki Takahashi; Nobutoshi Morimoto; Motonori Takamiya; Mizuki Morimoto; Satoshi Mino; Satoshi Kuramoto; Masamitsu Kawauchi; Kyoko Yokota; Koji Abe

doi:10.1016/j.jocn.2020.01.028

Successful treatment with corticosteroids for refractory deterioration of cryptococcal meningitis with an increasing cryptococcal antigen titer

Yoshiaki Takahashi, Nobutoshi Morimoto, Motonori Takamiya, Mizuki Morimoto, Satoshi Mino, Satoshi Kuramoto, Masamitsu Kawauchi, Kyoko Yokota, Koji Abe

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

We report a 55-year-old man with Cryptococcus neoformans meningitis who showed refractory deterioration twice with an increased cerebrospinal fluid cryptococcal antigen titer during the course of treatment. Although the initial deterioration was temporarily improved by placement of a ventriculoperitoneal shunt, he experienced deterioration again. However, he improved after administration of systemic corticosteroids. The present case suggests that systemic corticosteroid can be a choice of treatment to rescue immunocompetent patients with Cryptococcus neoformans meningitis and severe deterioration, even if cerebrospinal fluid analysis shows an increased cryptococcal antigen titer.

Original language	English
Pages (from-to)	455-457
Number of pages	3
Journal	Journal of Clinical Neuroscience
Volume	72
DOIs	https://doi.org/10.1016/j.jocn.2020.01.028
Publication status	Published - Feb 2020

Keywords

Corticosteroid
Cryptococcal antigen titer
Cryptococcus neoformans meningitis
Refractory deterioration
Ventriculoperitoneal shunt

ASJC Scopus subject areas

Surgery
Neurology
Clinical Neurology
Physiology (medical)

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10.1016/j.jocn.2020.01.028

Cite this

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title = "Successful treatment with corticosteroids for refractory deterioration of cryptococcal meningitis with an increasing cryptococcal antigen titer",

abstract = "We report a 55-year-old man with Cryptococcus neoformans meningitis who showed refractory deterioration twice with an increased cerebrospinal fluid cryptococcal antigen titer during the course of treatment. Although the initial deterioration was temporarily improved by placement of a ventriculoperitoneal shunt, he experienced deterioration again. However, he improved after administration of systemic corticosteroids. The present case suggests that systemic corticosteroid can be a choice of treatment to rescue immunocompetent patients with Cryptococcus neoformans meningitis and severe deterioration, even if cerebrospinal fluid analysis shows an increased cryptococcal antigen titer.",

keywords = "Corticosteroid, Cryptococcal antigen titer, Cryptococcus neoformans meningitis, Refractory deterioration, Ventriculoperitoneal shunt",

author = "Yoshiaki Takahashi and Nobutoshi Morimoto and Motonori Takamiya and Mizuki Morimoto and Satoshi Mino and Satoshi Kuramoto and Masamitsu Kawauchi and Kyoko Yokota and Koji Abe",

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T1 - Successful treatment with corticosteroids for refractory deterioration of cryptococcal meningitis with an increasing cryptococcal antigen titer

AU - Takahashi, Yoshiaki

AU - Morimoto, Nobutoshi

AU - Takamiya, Motonori

AU - Morimoto, Mizuki

AU - Mino, Satoshi

AU - Kuramoto, Satoshi

AU - Kawauchi, Masamitsu

AU - Yokota, Kyoko

AU - Abe, Koji

PY - 2020/2

Y1 - 2020/2

N2 - We report a 55-year-old man with Cryptococcus neoformans meningitis who showed refractory deterioration twice with an increased cerebrospinal fluid cryptococcal antigen titer during the course of treatment. Although the initial deterioration was temporarily improved by placement of a ventriculoperitoneal shunt, he experienced deterioration again. However, he improved after administration of systemic corticosteroids. The present case suggests that systemic corticosteroid can be a choice of treatment to rescue immunocompetent patients with Cryptococcus neoformans meningitis and severe deterioration, even if cerebrospinal fluid analysis shows an increased cryptococcal antigen titer.

AB - We report a 55-year-old man with Cryptococcus neoformans meningitis who showed refractory deterioration twice with an increased cerebrospinal fluid cryptococcal antigen titer during the course of treatment. Although the initial deterioration was temporarily improved by placement of a ventriculoperitoneal shunt, he experienced deterioration again. However, he improved after administration of systemic corticosteroids. The present case suggests that systemic corticosteroid can be a choice of treatment to rescue immunocompetent patients with Cryptococcus neoformans meningitis and severe deterioration, even if cerebrospinal fluid analysis shows an increased cryptococcal antigen titer.

KW - Corticosteroid

KW - Cryptococcal antigen titer

KW - Cryptococcus neoformans meningitis

KW - Refractory deterioration

KW - Ventriculoperitoneal shunt

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Successful treatment with corticosteroids for refractory deterioration of cryptococcal meningitis with an increasing cryptococcal antigen titer

Abstract

Keywords

ASJC Scopus subject areas

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