Successful treatment with corticosteroids for refractory deterioration of cryptococcal meningitis with an increasing cryptococcal antigen titer

Yoshiaki Takahashi, Nobutoshi Morimoto, Motonori Takamiya, Mizuki Morimoto, Satoshi Mino, Satoshi Kuramoto, Masamitsu Kawauchi, Kyoko Yokota, Koji Abe

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

We report a 55-year-old man with Cryptococcus neoformans meningitis who showed refractory deterioration twice with an increased cerebrospinal fluid cryptococcal antigen titer during the course of treatment. Although the initial deterioration was temporarily improved by placement of a ventriculoperitoneal shunt, he experienced deterioration again. However, he improved after administration of systemic corticosteroids. The present case suggests that systemic corticosteroid can be a choice of treatment to rescue immunocompetent patients with Cryptococcus neoformans meningitis and severe deterioration, even if cerebrospinal fluid analysis shows an increased cryptococcal antigen titer.

Original languageEnglish
Pages (from-to)455-457
Number of pages3
JournalJournal of Clinical Neuroscience
Volume72
DOIs
Publication statusPublished - Feb 2020

Keywords

  • Corticosteroid
  • Cryptococcal antigen titer
  • Cryptococcus neoformans meningitis
  • Refractory deterioration
  • Ventriculoperitoneal shunt

ASJC Scopus subject areas

  • Surgery
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

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