TY - JOUR
T1 - Successful treatment with corticosteroids for refractory deterioration of cryptococcal meningitis with an increasing cryptococcal antigen titer
AU - Takahashi, Yoshiaki
AU - Morimoto, Nobutoshi
AU - Takamiya, Motonori
AU - Morimoto, Mizuki
AU - Mino, Satoshi
AU - Kuramoto, Satoshi
AU - Kawauchi, Masamitsu
AU - Yokota, Kyoko
AU - Abe, Koji
PY - 2020/2
Y1 - 2020/2
N2 - We report a 55-year-old man with Cryptococcus neoformans meningitis who showed refractory deterioration twice with an increased cerebrospinal fluid cryptococcal antigen titer during the course of treatment. Although the initial deterioration was temporarily improved by placement of a ventriculoperitoneal shunt, he experienced deterioration again. However, he improved after administration of systemic corticosteroids. The present case suggests that systemic corticosteroid can be a choice of treatment to rescue immunocompetent patients with Cryptococcus neoformans meningitis and severe deterioration, even if cerebrospinal fluid analysis shows an increased cryptococcal antigen titer.
AB - We report a 55-year-old man with Cryptococcus neoformans meningitis who showed refractory deterioration twice with an increased cerebrospinal fluid cryptococcal antigen titer during the course of treatment. Although the initial deterioration was temporarily improved by placement of a ventriculoperitoneal shunt, he experienced deterioration again. However, he improved after administration of systemic corticosteroids. The present case suggests that systemic corticosteroid can be a choice of treatment to rescue immunocompetent patients with Cryptococcus neoformans meningitis and severe deterioration, even if cerebrospinal fluid analysis shows an increased cryptococcal antigen titer.
KW - Corticosteroid
KW - Cryptococcal antigen titer
KW - Cryptococcus neoformans meningitis
KW - Refractory deterioration
KW - Ventriculoperitoneal shunt
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U2 - 10.1016/j.jocn.2020.01.028
DO - 10.1016/j.jocn.2020.01.028
M3 - Article
C2 - 31952971
AN - SCOPUS:85077928956
VL - 72
SP - 455
EP - 457
JO - Journal of Clinical Neuroscience
JF - Journal of Clinical Neuroscience
SN - 0967-5868
ER -