Successful treatment with concurrent chemoradiotherapy followed by surgery for a patient with thymic adenocarcinoma

M. Shimono, A. Hiraki, H. Ueoka, Y. Tanimoto, M. Aoe, K. Sakae, K. Kaneda, M. Sakugawa, Katsuyuki Kiura, M. Harada

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Most neoplasms arising from the thymic epithelium are considered to be 'thymomas', which are composed of cytologically benign, neoplastic epithelial cells and non-neoplastic lymphocytes. In contrast, thymic epithelial neoplasms displaying cytologically malignant features have recently been classified as thymic carcinomas of various types of histology (1-6). However, primary thymic adenocarcinoma is extremely rare and only four cases of it have been reported in the literature (7). We report a rare case of primary thymic adenocarcinoma of 4-year complete remission with concurrent chemoradiotherapy followed by surgery. A 61-year-old Japanese man was referred to us complaining of facial edema and general fatigue. Computed tomography scans revealed a huge mass in the anterior mediastinum obstructing the superior vena cava. He was diagnosed with thymic adenocarcinoma on needle biopsy. He was treated with induction chemoradiotherapy consisting of cisplatin, 5-FU and concurrent thoracic radiation, which yielded a partial response. He then underwent surgical resection of the remaining mass. However, Pathologic examination of the resected mass revealed no malignant cells. The patient is doing well without symptoms or signs of relapse 53 months after diagnosis.

Original languageEnglish
Pages (from-to)2519-2522
Number of pages4
JournalAnticancer Research
Volume21
Issue number4 A
Publication statusPublished - 2001

Fingerprint

Chemoradiotherapy
Thymus Neoplasms
Adenocarcinoma
Thymoma
Superior Vena Cava
Glandular and Epithelial Neoplasms
Mediastinum
Needle Biopsy
Fluorouracil
Cisplatin
Signs and Symptoms
Fatigue
Edema
Histology
Thorax
Therapeutics
Epithelium
Epithelial Cells
Tomography
Lymphocytes

Keywords

  • Adjuvant chemoradiotherapy
  • Induction chemoradiotherapy
  • Papillary adenocarcinoma
  • Surgery
  • Thymic adenocarcinoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Shimono, M., Hiraki, A., Ueoka, H., Tanimoto, Y., Aoe, M., Sakae, K., ... Harada, M. (2001). Successful treatment with concurrent chemoradiotherapy followed by surgery for a patient with thymic adenocarcinoma. Anticancer Research, 21(4 A), 2519-2522.

Successful treatment with concurrent chemoradiotherapy followed by surgery for a patient with thymic adenocarcinoma. / Shimono, M.; Hiraki, A.; Ueoka, H.; Tanimoto, Y.; Aoe, M.; Sakae, K.; Kaneda, K.; Sakugawa, M.; Kiura, Katsuyuki; Harada, M.

In: Anticancer Research, Vol. 21, No. 4 A, 2001, p. 2519-2522.

Research output: Contribution to journalArticle

Shimono, M, Hiraki, A, Ueoka, H, Tanimoto, Y, Aoe, M, Sakae, K, Kaneda, K, Sakugawa, M, Kiura, K & Harada, M 2001, 'Successful treatment with concurrent chemoradiotherapy followed by surgery for a patient with thymic adenocarcinoma', Anticancer Research, vol. 21, no. 4 A, pp. 2519-2522.
Shimono M, Hiraki A, Ueoka H, Tanimoto Y, Aoe M, Sakae K et al. Successful treatment with concurrent chemoradiotherapy followed by surgery for a patient with thymic adenocarcinoma. Anticancer Research. 2001;21(4 A):2519-2522.
Shimono, M. ; Hiraki, A. ; Ueoka, H. ; Tanimoto, Y. ; Aoe, M. ; Sakae, K. ; Kaneda, K. ; Sakugawa, M. ; Kiura, Katsuyuki ; Harada, M. / Successful treatment with concurrent chemoradiotherapy followed by surgery for a patient with thymic adenocarcinoma. In: Anticancer Research. 2001 ; Vol. 21, No. 4 A. pp. 2519-2522.
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