Successful treatment of unresectable advanced hepatoblastoma

Living liver transplantation after surgical removal of lung metastasis

Takako Miyamura, Ryuichi Yoshida, Takahito Yagi, Hiroyoshi Matsukawa, Kousuke Chayama, Toshiaki Ishida, Kana Washio, Naoto Morishita, Megumi Oda, Tsuneo Morishima

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Hepatoblastoma is a rare malignant tumor of the liver in children. Intensive combination chemotherapy has increased the number of surgically resectable cases and improved prognosis markedly. However, unresectable cases and cases with residual metastasis, including lung metastases, have a poor prognosis. In these refractory cases, treatment strategy has not been established. On the other hand, living liver transplantation has been shown to be effective in cases of advanced hepatoblastoma, but its effectiveness in cases with residual distant metastases after chemotherapy remains unclear. We report one successful case of advanced unresectable hepatoblastoma with multiple lung metastases. Intensive chemotherapy consisting of high-dose chemotherapy with autologous hematopoietic stem cell transplantation was not effective. We performed living liver transplantation after surgical resection of residual lung metastases, which were histologically viable. After liver transplantation, the level of tumor marker decreased gradually. The patient experienced no severe complications. This case suggested that living liver transplantation could be effective in cases of advanced refractory hepatoblastoma after control of distant metastases.

Original languageEnglish
JournalPediatric Transplantation
Volume15
Issue number5
DOIs
Publication statusPublished - Aug 2011

Fingerprint

Hepatoblastoma
Liver Transplantation
Neoplasm Metastasis
Lung
Drug Therapy
Therapeutics
Hematopoietic Stem Cell Transplantation
Tumor Biomarkers
Combination Drug Therapy
Liver
Neoplasms

Keywords

  • hepatoblastoma
  • living liver transplantation
  • metastasis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Transplantation

Cite this

Successful treatment of unresectable advanced hepatoblastoma : Living liver transplantation after surgical removal of lung metastasis. / Miyamura, Takako; Yoshida, Ryuichi; Yagi, Takahito; Matsukawa, Hiroyoshi; Chayama, Kousuke; Ishida, Toshiaki; Washio, Kana; Morishita, Naoto; Oda, Megumi; Morishima, Tsuneo.

In: Pediatric Transplantation, Vol. 15, No. 5, 08.2011.

Research output: Contribution to journalArticle

Miyamura, Takako ; Yoshida, Ryuichi ; Yagi, Takahito ; Matsukawa, Hiroyoshi ; Chayama, Kousuke ; Ishida, Toshiaki ; Washio, Kana ; Morishita, Naoto ; Oda, Megumi ; Morishima, Tsuneo. / Successful treatment of unresectable advanced hepatoblastoma : Living liver transplantation after surgical removal of lung metastasis. In: Pediatric Transplantation. 2011 ; Vol. 15, No. 5.
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AU - Chayama, Kousuke

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