Successful treatment of recurrent candidemia due to candidal thrombophlebitis associated with a central venous catheter using a combination of fosfluconazole and micafungin

Hideharu Hagiya, Hiroki Kajioka

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Abstract

We herein report the case of an 85-year-old woman presenting with right internal jugular vein candidal thrombophlebitis associated with central venous catheters (CTCVC). The infecting agent was Candida albicans, which caused recurrent candidemia five times in total. Micafungin (MCFG) alone was ineffective; however, the combination of MCFG with fosfluconazole (F-FLCZ) successfully treated the patient without a need for any anticoagulant or surgical therapies. To the extent of our knowledge, this is the first report of CTCVC being successfully treated with a combination of F-FLCZ and MCFG. These new antifungal agents have better efficacy, tolerability and bioavailability; therefore, they can be useful alternatives to classical combination therapies such as amphotericin-B and 5-fluorocytosine.

Original languageEnglish
Pages (from-to)2139-2143
Number of pages5
JournalInternal Medicine
Volume52
Issue number18
DOIs
Publication statusPublished - Sep 24 2013

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Keywords

  • Candidemia
  • Fluconazole
  • Micafungin
  • Thrombophlebitis

ASJC Scopus subject areas

  • Internal Medicine

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