Successful treatment of proton pump inhibitor induced sporadic fundic gland polyps with an argon plasma coagulator in a patient with polycythaemia vera

Kazuya Kato, Yoshiaki Iwasaki, Masahiko Taniguchi, Kazuhiko Onodera, Takako Kawakami, Minoru Matsuda, Mineko Higuchi, Kimitaka Kato, Yurina Kato, Susumu Tamakawa, Hiroyuki Furukawa

Research output: Contribution to journalArticle

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Abstract

Introduction Proton pump inhibitor (PPI) use is associated with the development of fundic gland polyps (FGPs); discontinuing PPIs is associated with regression of FGPs. Here, we report a rare case of non-respondent FGPs after discontinuation of PPI that were successfully treated using an argon plasma coagulator (APC). Presentation of case We present the case of a 68-year-old woman with a history of polycytheamia vera. She also had gastroesophageal reflux disease (GERD) and had been taking 10 mg of omeprazole daily for the past three years. Esophagogastroduedenoscopy (GF) revealed over 100 pedunculated polyps in the gastric body and fundus. Histological examination of the specimens showed dilated oxyntic glands with flattened parietal and mucous cells. Based on these findings and the clinical history, a diagnosis of FGPs was made. Omeprazole use was then discontinued. Repeat GF performed 6 months and 1 year later showed a significant increase in the number and size of the polyps. APC treatment was performed every 6 months for 3 years. Further GF showed a significant decrease in the number and size of the FGPs 4 years after discontinuing PPI. Discussion We conclude that PPI use is a strong risk factor for the development of FGPs and discontinuing PPI is associated with regression of FGPs, but not in patients with polycythaemia vera. However, the mechanism involved in the interaction between FGP and polycytheamia vera remains unknown. Conclusion Non-respondent FGPs after discontinuation of PPI use may be successfully treated using APC.

Original languageEnglish
Pages (from-to)75-78
Number of pages4
JournalInternational Journal of Surgery Case Reports
Volume33
DOIs
Publication statusPublished - 2017

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Polycythemia Vera
Argon
Proton Pump Inhibitors
Polyps
Therapeutics
Omeprazole
Gastric Fundus
Gastroesophageal Reflux

Keywords

  • Proton pump inhibitors (PPI) gastric fundic gland polyp (FGP) TreatmentArgon plasma coagulator (APC) polycythaemia vera

ASJC Scopus subject areas

  • Surgery

Cite this

Successful treatment of proton pump inhibitor induced sporadic fundic gland polyps with an argon plasma coagulator in a patient with polycythaemia vera. / Kato, Kazuya; Iwasaki, Yoshiaki; Taniguchi, Masahiko; Onodera, Kazuhiko; Kawakami, Takako; Matsuda, Minoru; Higuchi, Mineko; Kato, Kimitaka; Kato, Yurina; Tamakawa, Susumu; Furukawa, Hiroyuki.

In: International Journal of Surgery Case Reports, Vol. 33, 2017, p. 75-78.

Research output: Contribution to journalArticle

Kato, Kazuya ; Iwasaki, Yoshiaki ; Taniguchi, Masahiko ; Onodera, Kazuhiko ; Kawakami, Takako ; Matsuda, Minoru ; Higuchi, Mineko ; Kato, Kimitaka ; Kato, Yurina ; Tamakawa, Susumu ; Furukawa, Hiroyuki. / Successful treatment of proton pump inhibitor induced sporadic fundic gland polyps with an argon plasma coagulator in a patient with polycythaemia vera. In: International Journal of Surgery Case Reports. 2017 ; Vol. 33. pp. 75-78.
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AU - Kato, Kazuya

AU - Iwasaki, Yoshiaki

AU - Taniguchi, Masahiko

AU - Onodera, Kazuhiko

AU - Kawakami, Takako

AU - Matsuda, Minoru

AU - Higuchi, Mineko

AU - Kato, Kimitaka

AU - Kato, Yurina

AU - Tamakawa, Susumu

AU - Furukawa, Hiroyuki

PY - 2017

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N2 - Introduction Proton pump inhibitor (PPI) use is associated with the development of fundic gland polyps (FGPs); discontinuing PPIs is associated with regression of FGPs. Here, we report a rare case of non-respondent FGPs after discontinuation of PPI that were successfully treated using an argon plasma coagulator (APC). Presentation of case We present the case of a 68-year-old woman with a history of polycytheamia vera. She also had gastroesophageal reflux disease (GERD) and had been taking 10 mg of omeprazole daily for the past three years. Esophagogastroduedenoscopy (GF) revealed over 100 pedunculated polyps in the gastric body and fundus. Histological examination of the specimens showed dilated oxyntic glands with flattened parietal and mucous cells. Based on these findings and the clinical history, a diagnosis of FGPs was made. Omeprazole use was then discontinued. Repeat GF performed 6 months and 1 year later showed a significant increase in the number and size of the polyps. APC treatment was performed every 6 months for 3 years. Further GF showed a significant decrease in the number and size of the FGPs 4 years after discontinuing PPI. Discussion We conclude that PPI use is a strong risk factor for the development of FGPs and discontinuing PPI is associated with regression of FGPs, but not in patients with polycythaemia vera. However, the mechanism involved in the interaction between FGP and polycytheamia vera remains unknown. Conclusion Non-respondent FGPs after discontinuation of PPI use may be successfully treated using APC.

AB - Introduction Proton pump inhibitor (PPI) use is associated with the development of fundic gland polyps (FGPs); discontinuing PPIs is associated with regression of FGPs. Here, we report a rare case of non-respondent FGPs after discontinuation of PPI that were successfully treated using an argon plasma coagulator (APC). Presentation of case We present the case of a 68-year-old woman with a history of polycytheamia vera. She also had gastroesophageal reflux disease (GERD) and had been taking 10 mg of omeprazole daily for the past three years. Esophagogastroduedenoscopy (GF) revealed over 100 pedunculated polyps in the gastric body and fundus. Histological examination of the specimens showed dilated oxyntic glands with flattened parietal and mucous cells. Based on these findings and the clinical history, a diagnosis of FGPs was made. Omeprazole use was then discontinued. Repeat GF performed 6 months and 1 year later showed a significant increase in the number and size of the polyps. APC treatment was performed every 6 months for 3 years. Further GF showed a significant decrease in the number and size of the FGPs 4 years after discontinuing PPI. Discussion We conclude that PPI use is a strong risk factor for the development of FGPs and discontinuing PPI is associated with regression of FGPs, but not in patients with polycythaemia vera. However, the mechanism involved in the interaction between FGP and polycytheamia vera remains unknown. Conclusion Non-respondent FGPs after discontinuation of PPI use may be successfully treated using APC.

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