Successful treatment of progresive Henoch-Schönlein purpura nephritis with tonsillectomy and steroid pulse therapy

Hitoshi Sugiyama, Naomi Watanabe, Tetsuya Onoda, Yoko Kikumoto, Miki Yamamoto, Manabu Maeta, Nobuya Ohara, Yohei Maeshima, Yasushi Yamasaki, Hirofumi Makino

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Henoch-Schönlein purpura (HSP) is a systemic disorder characterized by a leukocytoclastic vasculitis involving small vessels with the deposition of IgA immune complexes. The renal involvement is the major cause of morbidity and mortality in patients with HSP. We report here an adult patient with HSP nephritis (HSPN) accompanied by persistent proteinuria and progressive renal dysfunction despite conventional therapy. The patient was successfully treated with tonsillectomy followed by intravenous pulse methylprednisolone and oral prednisone. The combination therapy resulted in a significant decrease in proteinuria, improvement of renal function and the disappearance of microhematuria. The patient finally reached a stage of clinical remission.

Original languageEnglish
Pages (from-to)611-615
Number of pages5
JournalInternal Medicine
Volume44
Issue number6
DOIs
Publication statusPublished - Jun 2005

Keywords

  • Hematuria
  • IgA
  • Prednisolone
  • Proteinuria
  • Remission
  • Tonsil

ASJC Scopus subject areas

  • Internal Medicine

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