Abstract
We herein report a case of persistent methicillin-resistant Staphylococcus aureus (MRSA) bacteremia that was successfully treated with combination therapy consisting of high-dose daptomycin (DAP, 10 mg/kg) and rifampicin. The patient’s condition was complicated with multiple infectious foci, including an iliopsoas abscess and epidural abscess, as well as discitis and spondylitis at the cervical, thoracic and lumbar levels. Monotherapy treatments with vancomycin, linezolid and usual-dose DAP were all ineffective. It has been shown that usual-dose DAP administration may result in the emergence of a resistant strain and treatment failure. We would like to emphasize the importance of high-dose DAP therapy for MRSA bacteremia, a condition with a potentially high mortality rate.
| Original language | English |
|---|---|
| Pages (from-to) | 2159-2163 |
| Number of pages | 5 |
| Journal | Internal Medicine |
| Volume | 53 |
| Issue number | 18 |
| DOIs | |
| Publication status | Published - Sep 1 2014 |
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Keywords
- Butyrylcholinesterase (BChE) deficiency
- Daptomycin (DAP)
- Methicillin-resistant Staphylococcus aureus (MRSA)
- Staphylococcus aureus bacteremia (SAB)
ASJC Scopus subject areas
- Internal Medicine
- Medicine(all)
Cite this
Successful treatment of persistent MRSA bacteremia using high-dose daptomycin combined with rifampicin. / Hagiya, Hideharu; Terasaka, Tomohiro; Kimura, Kosuke; Satou, Asuka; Asano, Kikuko; Waseda, Koichi; Hanayama, Yoshihisa; Otsuka, Fumio.
In: Internal Medicine, Vol. 53, No. 18, 01.09.2014, p. 2159-2163.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Successful treatment of persistent MRSA bacteremia using high-dose daptomycin combined with rifampicin
AU - Hagiya, Hideharu
AU - Terasaka, Tomohiro
AU - Kimura, Kosuke
AU - Satou, Asuka
AU - Asano, Kikuko
AU - Waseda, Koichi
AU - Hanayama, Yoshihisa
AU - Otsuka, Fumio
PY - 2014/9/1
Y1 - 2014/9/1
N2 - We herein report a case of persistent methicillin-resistant Staphylococcus aureus (MRSA) bacteremia that was successfully treated with combination therapy consisting of high-dose daptomycin (DAP, 10 mg/kg) and rifampicin. The patient’s condition was complicated with multiple infectious foci, including an iliopsoas abscess and epidural abscess, as well as discitis and spondylitis at the cervical, thoracic and lumbar levels. Monotherapy treatments with vancomycin, linezolid and usual-dose DAP were all ineffective. It has been shown that usual-dose DAP administration may result in the emergence of a resistant strain and treatment failure. We would like to emphasize the importance of high-dose DAP therapy for MRSA bacteremia, a condition with a potentially high mortality rate.
AB - We herein report a case of persistent methicillin-resistant Staphylococcus aureus (MRSA) bacteremia that was successfully treated with combination therapy consisting of high-dose daptomycin (DAP, 10 mg/kg) and rifampicin. The patient’s condition was complicated with multiple infectious foci, including an iliopsoas abscess and epidural abscess, as well as discitis and spondylitis at the cervical, thoracic and lumbar levels. Monotherapy treatments with vancomycin, linezolid and usual-dose DAP were all ineffective. It has been shown that usual-dose DAP administration may result in the emergence of a resistant strain and treatment failure. We would like to emphasize the importance of high-dose DAP therapy for MRSA bacteremia, a condition with a potentially high mortality rate.
KW - Butyrylcholinesterase (BChE) deficiency
KW - Daptomycin (DAP)
KW - Methicillin-resistant Staphylococcus aureus (MRSA)
KW - Staphylococcus aureus bacteremia (SAB)
UR - http://www.scopus.com/inward/record.url?scp=84907459348&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84907459348&partnerID=8YFLogxK
U2 - 10.2169/internalmedicine.53.2711
DO - 10.2169/internalmedicine.53.2711
M3 - Article
C2 - 25224207
AN - SCOPUS:84907459348
VL - 53
SP - 2159
EP - 2163
JO - Internal Medicine
JF - Internal Medicine
SN - 0918-2918
IS - 18
ER -