Successful treatment of osteonecrosis-induced fractured mandible with teriparatide therapy: A case report

Mayumi Yao; Tsuyoshi Shimo; Yuko Ono; Kyoichi Obata; Norie Yoshioka; Akira Sasaki

doi:10.1016/j.ijscr.2016.02.028

Successful treatment of osteonecrosis-induced fractured mandible with teriparatide therapy: A case report

Mayumi Yao, Tsuyoshi Shimo, Yuko Ono, Kyoichi Obata, Norie Yoshioka, Akira Sasaki

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Introduction The management of medication-related osteonecrosis of the jaw (MRONJ) is controversial. To date, there is no established treatment for cases of advanced stage 3 MRONJ osteoporosis in elderly patients. Presentation An 87-year-old osteoporotic woman with osteonecrosis-induced left mandible fracture related to minodronate therapy was referred to us for treatment. She had a vertebral compression fracture concurrently and had started subcutaneous injection of teriparatide. After 18 months of treatment with teriparatide the pathological mandible fracture was healed and functional recovery of the occlusion was obtained by complete dentures. Discussion Teriparatide may have a powerful anabolic effect on bone, and promote bone regeneration against pathologic mandible fracture induced by MRONJ. Conclusion Based upon these findings, teriparatide might be beneficial for advanced stage 3 MRONJ osteoporosis in elderly patients.

Original language	English
Pages (from-to)	151-153
Number of pages	3
Journal	International Journal of Surgery Case Reports
Volume	21
DOIs	https://doi.org/10.1016/j.ijscr.2016.02.028
Publication status	Published - 2016

Keywords

Elderly
MRONJ
Osteoporosis
Teriparatide

ASJC Scopus subject areas

Surgery

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title = "Successful treatment of osteonecrosis-induced fractured mandible with teriparatide therapy: A case report",

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AU - Yao, Mayumi

AU - Shimo, Tsuyoshi

AU - Ono, Yuko

AU - Obata, Kyoichi

AU - Yoshioka, Norie

AU - Sasaki, Akira

PY - 2016

Y1 - 2016

N2 - Introduction The management of medication-related osteonecrosis of the jaw (MRONJ) is controversial. To date, there is no established treatment for cases of advanced stage 3 MRONJ osteoporosis in elderly patients. Presentation An 87-year-old osteoporotic woman with osteonecrosis-induced left mandible fracture related to minodronate therapy was referred to us for treatment. She had a vertebral compression fracture concurrently and had started subcutaneous injection of teriparatide. After 18 months of treatment with teriparatide the pathological mandible fracture was healed and functional recovery of the occlusion was obtained by complete dentures. Discussion Teriparatide may have a powerful anabolic effect on bone, and promote bone regeneration against pathologic mandible fracture induced by MRONJ. Conclusion Based upon these findings, teriparatide might be beneficial for advanced stage 3 MRONJ osteoporosis in elderly patients.

AB - Introduction The management of medication-related osteonecrosis of the jaw (MRONJ) is controversial. To date, there is no established treatment for cases of advanced stage 3 MRONJ osteoporosis in elderly patients. Presentation An 87-year-old osteoporotic woman with osteonecrosis-induced left mandible fracture related to minodronate therapy was referred to us for treatment. She had a vertebral compression fracture concurrently and had started subcutaneous injection of teriparatide. After 18 months of treatment with teriparatide the pathological mandible fracture was healed and functional recovery of the occlusion was obtained by complete dentures. Discussion Teriparatide may have a powerful anabolic effect on bone, and promote bone regeneration against pathologic mandible fracture induced by MRONJ. Conclusion Based upon these findings, teriparatide might be beneficial for advanced stage 3 MRONJ osteoporosis in elderly patients.

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