Successful treatment of osteonecrosis-induced fractured mandible with teriparatide therapy

A case report

Mayumi Yao, Tsuyoshi Shimo, Yuko Ono, Kyoichi Obata, Norie Yoshioka, Akira Sasaki

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Introduction: The management of medication-related osteonecrosis of the jaw (MRONJ) is controversial. To date, there is no established treatment for cases of advanced stage 3 MRONJ osteoporosis in elderly patients. Presentation: An 87-year-old osteoporotic woman with osteonecrosis-induced left mandible fracture related to minodronate therapy was referred to us for treatment. She had a vertebral compression fracture concurrently and had started subcutaneous injection of teriparatide. After 18 months of treatment with teriparatide the pathological mandible fracture was healed and functional recovery of the occlusion was obtained by complete dentures. Discussion: Teriparatide may have a powerful anabolic effect on bone, and promote bone regeneration against pathologic mandible fracture induced by MRONJ. Conclusion: Based upon these findings, teriparatide might be beneficial for advanced stage 3 MRONJ osteoporosis in elderly patients.

Original languageEnglish
JournalInternational Journal of Surgery Case Reports
DOIs
Publication statusAccepted/In press - Jan 26 2016

Fingerprint

Teriparatide
Osteonecrosis
Mandible
Jaw
Spontaneous Fractures
Osteoporosis
Therapeutics
Compression Fractures
Anabolic Agents
Complete Denture
Bone Regeneration
Subcutaneous Injections
Bone and Bones

Keywords

  • Elderly
  • MRONJ
  • Osteoporosis
  • Teriparatide

ASJC Scopus subject areas

  • Surgery

Cite this

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title = "Successful treatment of osteonecrosis-induced fractured mandible with teriparatide therapy: A case report",
abstract = "Introduction: The management of medication-related osteonecrosis of the jaw (MRONJ) is controversial. To date, there is no established treatment for cases of advanced stage 3 MRONJ osteoporosis in elderly patients. Presentation: An 87-year-old osteoporotic woman with osteonecrosis-induced left mandible fracture related to minodronate therapy was referred to us for treatment. She had a vertebral compression fracture concurrently and had started subcutaneous injection of teriparatide. After 18 months of treatment with teriparatide the pathological mandible fracture was healed and functional recovery of the occlusion was obtained by complete dentures. Discussion: Teriparatide may have a powerful anabolic effect on bone, and promote bone regeneration against pathologic mandible fracture induced by MRONJ. Conclusion: Based upon these findings, teriparatide might be beneficial for advanced stage 3 MRONJ osteoporosis in elderly patients.",
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T1 - Successful treatment of osteonecrosis-induced fractured mandible with teriparatide therapy

T2 - A case report

AU - Yao, Mayumi

AU - Shimo, Tsuyoshi

AU - Ono, Yuko

AU - Obata, Kyoichi

AU - Yoshioka, Norie

AU - Sasaki, Akira

PY - 2016/1/26

Y1 - 2016/1/26

N2 - Introduction: The management of medication-related osteonecrosis of the jaw (MRONJ) is controversial. To date, there is no established treatment for cases of advanced stage 3 MRONJ osteoporosis in elderly patients. Presentation: An 87-year-old osteoporotic woman with osteonecrosis-induced left mandible fracture related to minodronate therapy was referred to us for treatment. She had a vertebral compression fracture concurrently and had started subcutaneous injection of teriparatide. After 18 months of treatment with teriparatide the pathological mandible fracture was healed and functional recovery of the occlusion was obtained by complete dentures. Discussion: Teriparatide may have a powerful anabolic effect on bone, and promote bone regeneration against pathologic mandible fracture induced by MRONJ. Conclusion: Based upon these findings, teriparatide might be beneficial for advanced stage 3 MRONJ osteoporosis in elderly patients.

AB - Introduction: The management of medication-related osteonecrosis of the jaw (MRONJ) is controversial. To date, there is no established treatment for cases of advanced stage 3 MRONJ osteoporosis in elderly patients. Presentation: An 87-year-old osteoporotic woman with osteonecrosis-induced left mandible fracture related to minodronate therapy was referred to us for treatment. She had a vertebral compression fracture concurrently and had started subcutaneous injection of teriparatide. After 18 months of treatment with teriparatide the pathological mandible fracture was healed and functional recovery of the occlusion was obtained by complete dentures. Discussion: Teriparatide may have a powerful anabolic effect on bone, and promote bone regeneration against pathologic mandible fracture induced by MRONJ. Conclusion: Based upon these findings, teriparatide might be beneficial for advanced stage 3 MRONJ osteoporosis in elderly patients.

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KW - Osteoporosis

KW - Teriparatide

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