Abstract
Introduction: The management of medication-related osteonecrosis of the jaw (MRONJ) is controversial. To date, there is no established treatment for cases of advanced stage 3 MRONJ osteoporosis in elderly patients. Presentation: An 87-year-old osteoporotic woman with osteonecrosis-induced left mandible fracture related to minodronate therapy was referred to us for treatment. She had a vertebral compression fracture concurrently and had started subcutaneous injection of teriparatide. After 18 months of treatment with teriparatide the pathological mandible fracture was healed and functional recovery of the occlusion was obtained by complete dentures. Discussion: Teriparatide may have a powerful anabolic effect on bone, and promote bone regeneration against pathologic mandible fracture induced by MRONJ. Conclusion: Based upon these findings, teriparatide might be beneficial for advanced stage 3 MRONJ osteoporosis in elderly patients.
| Original language | English |
|---|---|
| Journal | International Journal of Surgery Case Reports |
| DOIs | |
| Publication status | Accepted/In press - Jan 26 2016 |
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Keywords
- Elderly
- MRONJ
- Osteoporosis
- Teriparatide
ASJC Scopus subject areas
- Surgery
Cite this
Successful treatment of osteonecrosis-induced fractured mandible with teriparatide therapy : A case report. / Yao, Mayumi; Shimo, Tsuyoshi; Ono, Yuko; Obata, Kyoichi; Yoshioka, Norie; Sasaki, Akira.
In: International Journal of Surgery Case Reports, 26.01.2016.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Successful treatment of osteonecrosis-induced fractured mandible with teriparatide therapy
T2 - A case report
AU - Yao, Mayumi
AU - Shimo, Tsuyoshi
AU - Ono, Yuko
AU - Obata, Kyoichi
AU - Yoshioka, Norie
AU - Sasaki, Akira
PY - 2016/1/26
Y1 - 2016/1/26
N2 - Introduction: The management of medication-related osteonecrosis of the jaw (MRONJ) is controversial. To date, there is no established treatment for cases of advanced stage 3 MRONJ osteoporosis in elderly patients. Presentation: An 87-year-old osteoporotic woman with osteonecrosis-induced left mandible fracture related to minodronate therapy was referred to us for treatment. She had a vertebral compression fracture concurrently and had started subcutaneous injection of teriparatide. After 18 months of treatment with teriparatide the pathological mandible fracture was healed and functional recovery of the occlusion was obtained by complete dentures. Discussion: Teriparatide may have a powerful anabolic effect on bone, and promote bone regeneration against pathologic mandible fracture induced by MRONJ. Conclusion: Based upon these findings, teriparatide might be beneficial for advanced stage 3 MRONJ osteoporosis in elderly patients.
AB - Introduction: The management of medication-related osteonecrosis of the jaw (MRONJ) is controversial. To date, there is no established treatment for cases of advanced stage 3 MRONJ osteoporosis in elderly patients. Presentation: An 87-year-old osteoporotic woman with osteonecrosis-induced left mandible fracture related to minodronate therapy was referred to us for treatment. She had a vertebral compression fracture concurrently and had started subcutaneous injection of teriparatide. After 18 months of treatment with teriparatide the pathological mandible fracture was healed and functional recovery of the occlusion was obtained by complete dentures. Discussion: Teriparatide may have a powerful anabolic effect on bone, and promote bone regeneration against pathologic mandible fracture induced by MRONJ. Conclusion: Based upon these findings, teriparatide might be beneficial for advanced stage 3 MRONJ osteoporosis in elderly patients.
KW - Elderly
KW - MRONJ
KW - Osteoporosis
KW - Teriparatide
UR - http://www.scopus.com/inward/record.url?scp=84959420004&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84959420004&partnerID=8YFLogxK
U2 - 10.1016/j.ijscr.2016.02.028
DO - 10.1016/j.ijscr.2016.02.028
M3 - Article
JO - International Journal of Surgery Case Reports
JF - International Journal of Surgery Case Reports
SN - 2210-2612
ER -