Successful Treatment of Metastatic Urothelial Carcinoma after Accurate Diagnosis by Immunohistochemistry

Research output: Contribution to journalArticle

Abstract

Urothelial carcinoma usually presents with hematuria, but cases of multiple lymphadenopathy with elevated S-pancreas-1 antigen (SPan-1) levels have not been reported. A 62-year-old Japanese man with lymphadenopathies was diagnosed with an adenocarcinoma of unknown origin and transferred to our hospital for further diagnosis. Serum carbohydrate antigen 19-9 and SPan-1 levels were extremely elevated. Uroplakin III immunostaining was positive in the inguinal lymph node, and cystoscopy revealed the presence of invasive urothelial carcinoma. Treatment with cisplatin and gemcitabine promoted a complete metabolic response for > 4 years. The detection of uroplakin III and serum SPan-1 might help diagnose urothelial carcinoma.

Original languageEnglish
Pages (from-to)279-284
Number of pages6
JournalActa medica Okayama
Volume73
Issue number3
DOIs
Publication statusPublished - Jun 1 2019

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Uroplakin III
Immunohistochemistry
Carcinoma
Antigens
Pancreas
gemcitabine
Cystoscopy
Groin
Hematuria
Therapeutics
Serum
Cisplatin
Adenocarcinoma
Lymph Nodes
Carbohydrates
Lymphadenopathy

Keywords

  • carbohydrate antigen 19-9
  • chemotherapy
  • s-pancreas-1 antigen
  • uroplakin III
  • urothelial carcinoma

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

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title = "Successful Treatment of Metastatic Urothelial Carcinoma after Accurate Diagnosis by Immunohistochemistry",
abstract = "Urothelial carcinoma usually presents with hematuria, but cases of multiple lymphadenopathy with elevated S-pancreas-1 antigen (SPan-1) levels have not been reported. A 62-year-old Japanese man with lymphadenopathies was diagnosed with an adenocarcinoma of unknown origin and transferred to our hospital for further diagnosis. Serum carbohydrate antigen 19-9 and SPan-1 levels were extremely elevated. Uroplakin III immunostaining was positive in the inguinal lymph node, and cystoscopy revealed the presence of invasive urothelial carcinoma. Treatment with cisplatin and gemcitabine promoted a complete metabolic response for > 4 years. The detection of uroplakin III and serum SPan-1 might help diagnose urothelial carcinoma.",
keywords = "carbohydrate antigen 19-9, chemotherapy, s-pancreas-1 antigen, uroplakin III, urothelial carcinoma",
author = "Go Makimoto and Hisakazu Nishimori and Reiko Kondo and Hiroyuki Yanai and Morito Sugimoto and Naohiro Oda and Toshio Kubo and Katsuyuki Hotta and Masahiro Tabata and Katsuyuki Kiura and Yoshinobu Maeda",
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TY - JOUR

T1 - Successful Treatment of Metastatic Urothelial Carcinoma after Accurate Diagnosis by Immunohistochemistry

AU - Makimoto, Go

AU - Nishimori, Hisakazu

AU - Kondo, Reiko

AU - Yanai, Hiroyuki

AU - Sugimoto, Morito

AU - Oda, Naohiro

AU - Kubo, Toshio

AU - Hotta, Katsuyuki

AU - Tabata, Masahiro

AU - Kiura, Katsuyuki

AU - Maeda, Yoshinobu

PY - 2019/6/1

Y1 - 2019/6/1

N2 - Urothelial carcinoma usually presents with hematuria, but cases of multiple lymphadenopathy with elevated S-pancreas-1 antigen (SPan-1) levels have not been reported. A 62-year-old Japanese man with lymphadenopathies was diagnosed with an adenocarcinoma of unknown origin and transferred to our hospital for further diagnosis. Serum carbohydrate antigen 19-9 and SPan-1 levels were extremely elevated. Uroplakin III immunostaining was positive in the inguinal lymph node, and cystoscopy revealed the presence of invasive urothelial carcinoma. Treatment with cisplatin and gemcitabine promoted a complete metabolic response for > 4 years. The detection of uroplakin III and serum SPan-1 might help diagnose urothelial carcinoma.

AB - Urothelial carcinoma usually presents with hematuria, but cases of multiple lymphadenopathy with elevated S-pancreas-1 antigen (SPan-1) levels have not been reported. A 62-year-old Japanese man with lymphadenopathies was diagnosed with an adenocarcinoma of unknown origin and transferred to our hospital for further diagnosis. Serum carbohydrate antigen 19-9 and SPan-1 levels were extremely elevated. Uroplakin III immunostaining was positive in the inguinal lymph node, and cystoscopy revealed the presence of invasive urothelial carcinoma. Treatment with cisplatin and gemcitabine promoted a complete metabolic response for > 4 years. The detection of uroplakin III and serum SPan-1 might help diagnose urothelial carcinoma.

KW - carbohydrate antigen 19-9

KW - chemotherapy

KW - s-pancreas-1 antigen

KW - uroplakin III

KW - urothelial carcinoma

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