Successful treatment of genital warts with ingenol mebutate monitored with optical coherence tomography and reflectance confocal microscopy

Markus Reinholz, Benjamin M. Clanner-Engelshofen, Markus V. Heppt, Youji Hirai, Thomas Ruzicka, Carola Berking, Tanja Von Braunmühl

Research output: Contribution to journalArticle

Abstract

Ingenol mebutate (IM) is approved for the treatment of actinic keratosis and induces cell death in precancerous lesions. The efficacy of IM in the treatment of genital warts was investigated in a therapy-refractory patient. The 74-year-old male was treated with IM gel for three consecutive days. Treatment course and efficacy were evaluated by clinical inspection and non-invasive diagnostics namely optical coherence tomography (OCT) and reflectance confocal microscopy (RCM). Within 24 to 48 hours IM induced a strong local inflammatory reaction. One week later a complete response was observed. OCT and RCM showed a strong reaction after treatment with erosions, swelling of cells, and a subepidermal dark band in representative lesions. IM has the advantage of a short treatment period in contrast to other topical treatments and shows a promising clinical outcome. Larger studies are needed to validate the data.

Original languageEnglish
Pages (from-to)434-437
Number of pages4
JournalAnnals of Dermatology
Volume31
Issue number4
DOIs
Publication statusPublished - Jan 1 2019

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Condylomata Acuminata
Optical Coherence Tomography
Confocal Microscopy
Therapeutics
Actinic Keratosis
3-ingenyl angelate
Cell Death
Gels

Keywords

  • Condylomata acuminata
  • Confocal
  • Microscopy
  • Neoplasms
  • Optical coherence tomography

ASJC Scopus subject areas

  • Dermatology

Cite this

Successful treatment of genital warts with ingenol mebutate monitored with optical coherence tomography and reflectance confocal microscopy. / Reinholz, Markus; Clanner-Engelshofen, Benjamin M.; Heppt, Markus V.; Hirai, Youji; Ruzicka, Thomas; Berking, Carola; Von Braunmühl, Tanja.

In: Annals of Dermatology, Vol. 31, No. 4, 01.01.2019, p. 434-437.

Research output: Contribution to journalArticle

Reinholz, Markus ; Clanner-Engelshofen, Benjamin M. ; Heppt, Markus V. ; Hirai, Youji ; Ruzicka, Thomas ; Berking, Carola ; Von Braunmühl, Tanja. / Successful treatment of genital warts with ingenol mebutate monitored with optical coherence tomography and reflectance confocal microscopy. In: Annals of Dermatology. 2019 ; Vol. 31, No. 4. pp. 434-437.
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