Successful treatment of brain metastasis developing after prophylactic cranial irradiation in patients with small-cell lung cancer by low-dose whole brain irradiation plus intra-arterial infusion of cisplatin

Hiroshi Ueoka, Katsuyuki Kiura, Kenichi Chikamori, Naoyuki Nogami, Haruyuki Kawai, Ichiro Takata, Takuya Nagata, Akio Hiraki, Nobukazu Fujimoto, Kohich Kunisada, Yoshio Hiraki, Katsuyoshi Sakae, Shunkichi Hirakt, Mine Harada

Research output: Contribution to journalArticlepeer-review

Abstract

Problem: Overall survival has been substantially improved in limited disease small-cell lung cancer (LD-SCLC) with a combination of thoracic irradiation and systemic chemotherapy. However, late brain relapse, developing especially after prophylactic cranial irradiation (PCI), is one of the major obstacles to achieving the further improvement. Methods: Sixty-nine patients with LD-SCLC who developed brain relapse were retrospectively analyzed to evaluate the effect of salvage treatment on survival. Of those, 55 patients have received PCI. Results: A combined modality treatment consisting of low-dose cranial irradiation plus intra-arterial infusion of cisplatin resulted in better long-term survival for SCLC patients with brain relapse after PCI compared with cranial irradiation alone or best supportive care alone. A 42-year old patient receiving the CMT has continued a complete response for 10 years. Conclusions: A combined modality treatment consisting of low-dose cranial irradiation plus intra-arterial infusion of cisplatin is effective for treatment of brain relapse and warrants further study in SCLC patients developing brain metastasis after PCI.

Original languageEnglish
Pages (from-to)227-233
Number of pages7
JournalCancer Research, Therapy and Control
Volume10
Issue number3
Publication statusPublished - Dec 1 1999

Keywords

  • Brain metastasis
  • Intra-arterial chemotherapy
  • PCI
  • Small-cell lung cancer
  • Whole brain irradiation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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