Successful re-administration of osimertinib in osimertinib-induced interstitial lung disease with an organizing pneumonia pattern: A case report and literature review

Junko Itano, Hisao Higo, Kadoaki Ohashi, Go Makimoto, Kazuya Nishii, Katsuyuki Hotta, Nobuaki Miyahara, Yoshinobu Maeda, Katsuyuki Kiura

Research output: Contribution to journalReview article

Abstract

Osimertinib is the standard therapy for epidermal-growth-factor-receptor (EGFR)-mutant lung cancers. We herein report a case of osimertinib-induced interstitial lung disease (OsiILD) with an organizing pneumonia (OP) pattern and provide a literature-based review. Six months after osimertinib administration, a 75-year-old woman with right pleural carcinomatosis developed ILD with an OP pattern. After salvage chemotherapy, osimertinib with corticosteroid was successfully re-administered. A literature review suggested that 1) OsiILD with an OP pattern was rare but should be recognized, and 2) re-administration of osimertinib in OsiILD was successful in select patients. A criterion that determines whether a patient would benefit from re-administration is warranted.

Original languageEnglish
Pages (from-to)823-828
Number of pages6
JournalInternal Medicine
Volume59
Issue number6
DOIs
Publication statusPublished - Mar 15 2020

Keywords

  • Drug-induced ILD
  • Organizing pneumonia pattern
  • Osimertinib
  • Re-administration
  • Reversed halo sign

ASJC Scopus subject areas

  • Internal Medicine

Fingerprint Dive into the research topics of 'Successful re-administration of osimertinib in osimertinib-induced interstitial lung disease with an organizing pneumonia pattern: A case report and literature review'. Together they form a unique fingerprint.

  • Cite this