Abstract
Diffuse pulmonary arteriovenous malformations (AVMs) are associated with a poor prognosis and the therapeutic strategy remains controversial. We describe a pediatric patient with diffuse pulmonary AVMs associated with hereditary hemorrhagic telangiectasia (HHT), who presented with two cerebral AVMs in the parietal and occipital lobes as well. Of note, successful bilateral lung transplantation not only improved the hypoxemia but also resulted in size reduction of the cerebral AVMs. Although it is essential to consider involvements other than pulmonary AVMs, especially brain AVMs, to decide the indication, lung transplantation can be a viable therapeutic option for patients with diffuse pulmonary AVMs and HHT. The authors describe a successful lung transplant in a patient with diffuse pulmonary arteriovenous malformations and hereditary hemorrhagic telangiectasia, focusing on its potential to improve cerebral arteriovenous malformations.
| Original language | English |
|---|---|
| Pages (from-to) | 3278-3281 |
| Number of pages | 4 |
| Journal | American Journal of Transplantation |
| Volume | 13 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - Dec 2013 |
Fingerprint
Keywords
- Cerebral arteriovenous malformation
- Hereditary hemorrhagic telangiectasia
- Lung transplantation
- Pulmonary arteriovenous malformation
ASJC Scopus subject areas
- Transplantation
- Immunology and Allergy
- Pharmacology (medical)
Cite this
Successful lung transplantation in a case with diffuse pulmonary arteriovenous malformations and hereditary hemorrhagic telangiectasia. / Fukushima, H.; Mitsuhashi, T.; Oto, Takahiro; Sano, Y.; Kusano, K. F.; Goto, K.; Okazaki, M.; Date, H.; Kojima, Y.; Yamagishi, H.; Takahashi, T.
In: American Journal of Transplantation, Vol. 13, No. 12, 12.2013, p. 3278-3281.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Successful lung transplantation in a case with diffuse pulmonary arteriovenous malformations and hereditary hemorrhagic telangiectasia
AU - Fukushima, H.
AU - Mitsuhashi, T.
AU - Oto, Takahiro
AU - Sano, Y.
AU - Kusano, K. F.
AU - Goto, K.
AU - Okazaki, M.
AU - Date, H.
AU - Kojima, Y.
AU - Yamagishi, H.
AU - Takahashi, T.
PY - 2013/12
Y1 - 2013/12
N2 - Diffuse pulmonary arteriovenous malformations (AVMs) are associated with a poor prognosis and the therapeutic strategy remains controversial. We describe a pediatric patient with diffuse pulmonary AVMs associated with hereditary hemorrhagic telangiectasia (HHT), who presented with two cerebral AVMs in the parietal and occipital lobes as well. Of note, successful bilateral lung transplantation not only improved the hypoxemia but also resulted in size reduction of the cerebral AVMs. Although it is essential to consider involvements other than pulmonary AVMs, especially brain AVMs, to decide the indication, lung transplantation can be a viable therapeutic option for patients with diffuse pulmonary AVMs and HHT. The authors describe a successful lung transplant in a patient with diffuse pulmonary arteriovenous malformations and hereditary hemorrhagic telangiectasia, focusing on its potential to improve cerebral arteriovenous malformations.
AB - Diffuse pulmonary arteriovenous malformations (AVMs) are associated with a poor prognosis and the therapeutic strategy remains controversial. We describe a pediatric patient with diffuse pulmonary AVMs associated with hereditary hemorrhagic telangiectasia (HHT), who presented with two cerebral AVMs in the parietal and occipital lobes as well. Of note, successful bilateral lung transplantation not only improved the hypoxemia but also resulted in size reduction of the cerebral AVMs. Although it is essential to consider involvements other than pulmonary AVMs, especially brain AVMs, to decide the indication, lung transplantation can be a viable therapeutic option for patients with diffuse pulmonary AVMs and HHT. The authors describe a successful lung transplant in a patient with diffuse pulmonary arteriovenous malformations and hereditary hemorrhagic telangiectasia, focusing on its potential to improve cerebral arteriovenous malformations.
KW - Cerebral arteriovenous malformation
KW - Hereditary hemorrhagic telangiectasia
KW - Lung transplantation
KW - Pulmonary arteriovenous malformation
UR - http://www.scopus.com/inward/record.url?scp=84888379941&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84888379941&partnerID=8YFLogxK
U2 - 10.1111/ajt.12499
DO - 10.1111/ajt.12499
M3 - Article
VL - 13
SP - 3278
EP - 3281
JO - American Journal of Transplantation
JF - American Journal of Transplantation
SN - 1600-6135
IS - 12
ER -