Successful lung transplantation in a case with diffuse pulmonary arteriovenous malformations and hereditary hemorrhagic telangiectasia

H. Fukushima, T. Mitsuhashi, Takahiro Oto, Y. Sano, K. F. Kusano, K. Goto, M. Okazaki, H. Date, Y. Kojima, H. Yamagishi, T. Takahashi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Diffuse pulmonary arteriovenous malformations (AVMs) are associated with a poor prognosis and the therapeutic strategy remains controversial. We describe a pediatric patient with diffuse pulmonary AVMs associated with hereditary hemorrhagic telangiectasia (HHT), who presented with two cerebral AVMs in the parietal and occipital lobes as well. Of note, successful bilateral lung transplantation not only improved the hypoxemia but also resulted in size reduction of the cerebral AVMs. Although it is essential to consider involvements other than pulmonary AVMs, especially brain AVMs, to decide the indication, lung transplantation can be a viable therapeutic option for patients with diffuse pulmonary AVMs and HHT. The authors describe a successful lung transplant in a patient with diffuse pulmonary arteriovenous malformations and hereditary hemorrhagic telangiectasia, focusing on its potential to improve cerebral arteriovenous malformations.

Original languageEnglish
Pages (from-to)3278-3281
Number of pages4
JournalAmerican Journal of Transplantation
Volume13
Issue number12
DOIs
Publication statusPublished - Dec 2013

Fingerprint

Hereditary Hemorrhagic Telangiectasia
Lung Transplantation
Arteriovenous Malformations
Intracranial Arteriovenous Malformations
Lung
Occipital Lobe
Parietal Lobe
Pediatrics
Transplants
Brain
Therapeutics

Keywords

  • Cerebral arteriovenous malformation
  • Hereditary hemorrhagic telangiectasia
  • Lung transplantation
  • Pulmonary arteriovenous malformation

ASJC Scopus subject areas

  • Transplantation
  • Immunology and Allergy
  • Pharmacology (medical)

Cite this

Successful lung transplantation in a case with diffuse pulmonary arteriovenous malformations and hereditary hemorrhagic telangiectasia. / Fukushima, H.; Mitsuhashi, T.; Oto, Takahiro; Sano, Y.; Kusano, K. F.; Goto, K.; Okazaki, M.; Date, H.; Kojima, Y.; Yamagishi, H.; Takahashi, T.

In: American Journal of Transplantation, Vol. 13, No. 12, 12.2013, p. 3278-3281.

Research output: Contribution to journalArticle

Fukushima, H, Mitsuhashi, T, Oto, T, Sano, Y, Kusano, KF, Goto, K, Okazaki, M, Date, H, Kojima, Y, Yamagishi, H & Takahashi, T 2013, 'Successful lung transplantation in a case with diffuse pulmonary arteriovenous malformations and hereditary hemorrhagic telangiectasia', American Journal of Transplantation, vol. 13, no. 12, pp. 3278-3281. https://doi.org/10.1111/ajt.12499
Fukushima, H. ; Mitsuhashi, T. ; Oto, Takahiro ; Sano, Y. ; Kusano, K. F. ; Goto, K. ; Okazaki, M. ; Date, H. ; Kojima, Y. ; Yamagishi, H. ; Takahashi, T. / Successful lung transplantation in a case with diffuse pulmonary arteriovenous malformations and hereditary hemorrhagic telangiectasia. In: American Journal of Transplantation. 2013 ; Vol. 13, No. 12. pp. 3278-3281.
@article{2fb48d3a89af4f4d97ac00582f0f91c7,
title = "Successful lung transplantation in a case with diffuse pulmonary arteriovenous malformations and hereditary hemorrhagic telangiectasia",
abstract = "Diffuse pulmonary arteriovenous malformations (AVMs) are associated with a poor prognosis and the therapeutic strategy remains controversial. We describe a pediatric patient with diffuse pulmonary AVMs associated with hereditary hemorrhagic telangiectasia (HHT), who presented with two cerebral AVMs in the parietal and occipital lobes as well. Of note, successful bilateral lung transplantation not only improved the hypoxemia but also resulted in size reduction of the cerebral AVMs. Although it is essential to consider involvements other than pulmonary AVMs, especially brain AVMs, to decide the indication, lung transplantation can be a viable therapeutic option for patients with diffuse pulmonary AVMs and HHT. The authors describe a successful lung transplant in a patient with diffuse pulmonary arteriovenous malformations and hereditary hemorrhagic telangiectasia, focusing on its potential to improve cerebral arteriovenous malformations.",
keywords = "Cerebral arteriovenous malformation, Hereditary hemorrhagic telangiectasia, Lung transplantation, Pulmonary arteriovenous malformation",
author = "H. Fukushima and T. Mitsuhashi and Takahiro Oto and Y. Sano and Kusano, {K. F.} and K. Goto and M. Okazaki and H. Date and Y. Kojima and H. Yamagishi and T. Takahashi",
year = "2013",
month = "12",
doi = "10.1111/ajt.12499",
language = "English",
volume = "13",
pages = "3278--3281",
journal = "American Journal of Transplantation",
issn = "1600-6135",
publisher = "Wiley-Blackwell",
number = "12",

}

TY - JOUR

T1 - Successful lung transplantation in a case with diffuse pulmonary arteriovenous malformations and hereditary hemorrhagic telangiectasia

AU - Fukushima, H.

AU - Mitsuhashi, T.

AU - Oto, Takahiro

AU - Sano, Y.

AU - Kusano, K. F.

AU - Goto, K.

AU - Okazaki, M.

AU - Date, H.

AU - Kojima, Y.

AU - Yamagishi, H.

AU - Takahashi, T.

PY - 2013/12

Y1 - 2013/12

N2 - Diffuse pulmonary arteriovenous malformations (AVMs) are associated with a poor prognosis and the therapeutic strategy remains controversial. We describe a pediatric patient with diffuse pulmonary AVMs associated with hereditary hemorrhagic telangiectasia (HHT), who presented with two cerebral AVMs in the parietal and occipital lobes as well. Of note, successful bilateral lung transplantation not only improved the hypoxemia but also resulted in size reduction of the cerebral AVMs. Although it is essential to consider involvements other than pulmonary AVMs, especially brain AVMs, to decide the indication, lung transplantation can be a viable therapeutic option for patients with diffuse pulmonary AVMs and HHT. The authors describe a successful lung transplant in a patient with diffuse pulmonary arteriovenous malformations and hereditary hemorrhagic telangiectasia, focusing on its potential to improve cerebral arteriovenous malformations.

AB - Diffuse pulmonary arteriovenous malformations (AVMs) are associated with a poor prognosis and the therapeutic strategy remains controversial. We describe a pediatric patient with diffuse pulmonary AVMs associated with hereditary hemorrhagic telangiectasia (HHT), who presented with two cerebral AVMs in the parietal and occipital lobes as well. Of note, successful bilateral lung transplantation not only improved the hypoxemia but also resulted in size reduction of the cerebral AVMs. Although it is essential to consider involvements other than pulmonary AVMs, especially brain AVMs, to decide the indication, lung transplantation can be a viable therapeutic option for patients with diffuse pulmonary AVMs and HHT. The authors describe a successful lung transplant in a patient with diffuse pulmonary arteriovenous malformations and hereditary hemorrhagic telangiectasia, focusing on its potential to improve cerebral arteriovenous malformations.

KW - Cerebral arteriovenous malformation

KW - Hereditary hemorrhagic telangiectasia

KW - Lung transplantation

KW - Pulmonary arteriovenous malformation

UR - http://www.scopus.com/inward/record.url?scp=84888379941&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84888379941&partnerID=8YFLogxK

U2 - 10.1111/ajt.12499

DO - 10.1111/ajt.12499

M3 - Article

VL - 13

SP - 3278

EP - 3281

JO - American Journal of Transplantation

JF - American Journal of Transplantation

SN - 1600-6135

IS - 12

ER -