Successful lung transplantation in a case with diffuse pulmonary arteriovenous malformations and hereditary hemorrhagic telangiectasia

H. Fukushima, T. Mitsuhashi, T. Oto, Y. Sano, K. F. Kusano, K. Goto, M. Okazaki, H. Date, Y. Kojima, H. Yamagishi, T. Takahashi

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9 Citations (Scopus)

Abstract

Diffuse pulmonary arteriovenous malformations (AVMs) are associated with a poor prognosis and the therapeutic strategy remains controversial. We describe a pediatric patient with diffuse pulmonary AVMs associated with hereditary hemorrhagic telangiectasia (HHT), who presented with two cerebral AVMs in the parietal and occipital lobes as well. Of note, successful bilateral lung transplantation not only improved the hypoxemia but also resulted in size reduction of the cerebral AVMs. Although it is essential to consider involvements other than pulmonary AVMs, especially brain AVMs, to decide the indication, lung transplantation can be a viable therapeutic option for patients with diffuse pulmonary AVMs and HHT. The authors describe a successful lung transplant in a patient with diffuse pulmonary arteriovenous malformations and hereditary hemorrhagic telangiectasia, focusing on its potential to improve cerebral arteriovenous malformations.

Original languageEnglish
Pages (from-to)3278-3281
Number of pages4
JournalAmerican Journal of Transplantation
Volume13
Issue number12
DOIs
Publication statusPublished - Dec 2013

Keywords

  • Cerebral arteriovenous malformation
  • Hereditary hemorrhagic telangiectasia
  • Lung transplantation
  • Pulmonary arteriovenous malformation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

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    Fukushima, H., Mitsuhashi, T., Oto, T., Sano, Y., Kusano, K. F., Goto, K., Okazaki, M., Date, H., Kojima, Y., Yamagishi, H., & Takahashi, T. (2013). Successful lung transplantation in a case with diffuse pulmonary arteriovenous malformations and hereditary hemorrhagic telangiectasia. American Journal of Transplantation, 13(12), 3278-3281. https://doi.org/10.1111/ajt.12499