Successful extracorporeal life support for life-threatening hypercapnia with Bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation

Koichi Waseda; Yasushi Tanimoto; Shingo Ichib; Nobuaki Miyahara; Toshi Murakami; Nobuaki Ochi; Michihisa Terado; Osamu Nagano; Yoshinobu Maeda; Arihiko Kanehiro; Yoshihito Ujike; Mitsune Tanimoto

Successful extracorporeal life support for life-threatening hypercapnia with Bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation

Koichi Waseda, Yasushi Tanimoto, Shingo Ichib, Nobuaki Miyahara, Toshi Murakami, Nobuaki Ochi, Michihisa Terado, Osamu Nagano, Yoshinobu Maeda, Arihiko Kanehiro, Yoshihito Ujike, Mitsune Tanimoto

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Bronchiolitis obliterans (BO) is a disease with a poor prognosis, and a key factor that limits long-term survival after allogeneic hematopoietic stem cell transplantation (HSCT). We here report a case of a 31-year woman with acute lymphatic leukemia, which was treated by chemotherapy and HSCT, and consequently developed BO 2 years after HSCT. A non-tuberculous mycobacterial infection occurred and showed gradual exacerbation. She started taking anti-mycobacterial drugs, but lost appetite, felt tired and finally lost consciousness one month after beginning medication. Arterial blood gas revealed marked hypercapnia. Using extracorporeal life support (ECLS), the carbon dioxide concentration was reduced and her consciousness recovered. To our knowledge, this is the first case in which ECLS was successfully used for hypercapnia in a patient with BO.

Original language	English
Pages (from-to)	403-406
Number of pages	4
Journal	Acta medica Okayama
Volume	65
Issue number	6
Publication status	Published - Dec 22 2011

Keywords

Bronchiolitis obliterans
Extracorporeal life support
Hypercapnia
Noninvasive positive pressure ventilation

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Cite this

@article{a5f343d908d44de09110379e8ecdc705,

title = "Successful extracorporeal life support for life-threatening hypercapnia with Bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation",

abstract = "Bronchiolitis obliterans (BO) is a disease with a poor prognosis, and a key factor that limits long-term survival after allogeneic hematopoietic stem cell transplantation (HSCT). We here report a case of a 31-year woman with acute lymphatic leukemia, which was treated by chemotherapy and HSCT, and consequently developed BO 2 years after HSCT. A non-tuberculous mycobacterial infection occurred and showed gradual exacerbation. She started taking anti-mycobacterial drugs, but lost appetite, felt tired and finally lost consciousness one month after beginning medication. Arterial blood gas revealed marked hypercapnia. Using extracorporeal life support (ECLS), the carbon dioxide concentration was reduced and her consciousness recovered. To our knowledge, this is the first case in which ECLS was successfully used for hypercapnia in a patient with BO.",

keywords = "Bronchiolitis obliterans, Extracorporeal life support, Hypercapnia, Noninvasive positive pressure ventilation",

author = "Koichi Waseda and Yasushi Tanimoto and Shingo Ichib and Nobuaki Miyahara and Toshi Murakami and Nobuaki Ochi and Michihisa Terado and Osamu Nagano and Yoshinobu Maeda and Arihiko Kanehiro and Yoshihito Ujike and Mitsune Tanimoto",

year = "2011",

month = dec,

day = "22",

language = "English",

volume = "65",

pages = "403--406",

journal = "Acta Medica Okayama",

issn = "0386-300X",

publisher = "Okayama University",

number = "6",

}

TY - JOUR

T1 - Successful extracorporeal life support for life-threatening hypercapnia with Bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation

AU - Waseda, Koichi

AU - Tanimoto, Yasushi

AU - Ichib, Shingo

AU - Miyahara, Nobuaki

AU - Murakami, Toshi

AU - Ochi, Nobuaki

AU - Terado, Michihisa

AU - Nagano, Osamu

AU - Maeda, Yoshinobu

AU - Kanehiro, Arihiko

AU - Ujike, Yoshihito

AU - Tanimoto, Mitsune

PY - 2011/12/22

Y1 - 2011/12/22

N2 - Bronchiolitis obliterans (BO) is a disease with a poor prognosis, and a key factor that limits long-term survival after allogeneic hematopoietic stem cell transplantation (HSCT). We here report a case of a 31-year woman with acute lymphatic leukemia, which was treated by chemotherapy and HSCT, and consequently developed BO 2 years after HSCT. A non-tuberculous mycobacterial infection occurred and showed gradual exacerbation. She started taking anti-mycobacterial drugs, but lost appetite, felt tired and finally lost consciousness one month after beginning medication. Arterial blood gas revealed marked hypercapnia. Using extracorporeal life support (ECLS), the carbon dioxide concentration was reduced and her consciousness recovered. To our knowledge, this is the first case in which ECLS was successfully used for hypercapnia in a patient with BO.

AB - Bronchiolitis obliterans (BO) is a disease with a poor prognosis, and a key factor that limits long-term survival after allogeneic hematopoietic stem cell transplantation (HSCT). We here report a case of a 31-year woman with acute lymphatic leukemia, which was treated by chemotherapy and HSCT, and consequently developed BO 2 years after HSCT. A non-tuberculous mycobacterial infection occurred and showed gradual exacerbation. She started taking anti-mycobacterial drugs, but lost appetite, felt tired and finally lost consciousness one month after beginning medication. Arterial blood gas revealed marked hypercapnia. Using extracorporeal life support (ECLS), the carbon dioxide concentration was reduced and her consciousness recovered. To our knowledge, this is the first case in which ECLS was successfully used for hypercapnia in a patient with BO.

KW - Bronchiolitis obliterans

KW - Extracorporeal life support

KW - Hypercapnia

KW - Noninvasive positive pressure ventilation

UR - http://www.scopus.com/inward/record.url?scp=84858163703&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84858163703&partnerID=8YFLogxK

M3 - Article

C2 - 22189481

AN - SCOPUS:84858163703

SN - 0386-300X

VL - 65

SP - 403

EP - 406

JO - Acta Medica Okayama

JF - Acta Medica Okayama

IS - 6

ER -

Successful extracorporeal life support for life-threatening hypercapnia with Bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation

Abstract

Keywords

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this