Successful extracorporeal life support for life-threatening hypercapnia with Bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation

Koichi Waseda, Yasushi Tanimoto, Shingo Ichib, Nobuaki Miyahara, Toshi Murakami, Nobuaki Ochi, Michihisa Terado, Osamu Nagano, Yoshinobu Maeda, Arihiko Kanehiro, Yoshihito Ujike, Mitsune Tanimoto

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Bronchiolitis obliterans (BO) is a disease with a poor prognosis, and a key factor that limits long-term survival after allogeneic hematopoietic stem cell transplantation (HSCT). We here report a case of a 31-year woman with acute lymphatic leukemia, which was treated by chemotherapy and HSCT, and consequently developed BO 2 years after HSCT. A non-tuberculous mycobacterial infection occurred and showed gradual exacerbation. She started taking anti-mycobacterial drugs, but lost appetite, felt tired and finally lost consciousness one month after beginning medication. Arterial blood gas revealed marked hypercapnia. Using extracorporeal life support (ECLS), the carbon dioxide concentration was reduced and her consciousness recovered. To our knowledge, this is the first case in which ECLS was successfully used for hypercapnia in a patient with BO.

Original languageEnglish
Pages (from-to)403-406
Number of pages4
JournalActa Medica Okayama
Volume65
Issue number6
Publication statusPublished - Dec 22 2011

Fingerprint

Bronchiolitis Obliterans
Extracorporeal Membrane Oxygenation
Hypercapnia
Hematopoietic Stem Cell Transplantation
Stem cells
Consciousness
Chemotherapy
Appetite
Carbon Dioxide
Leukemia
Blood
Gases
Drug Therapy
Survival
Infection
Pharmaceutical Preparations

Keywords

  • Bronchiolitis obliterans
  • Extracorporeal life support
  • Hypercapnia
  • Noninvasive positive pressure ventilation

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Successful extracorporeal life support for life-threatening hypercapnia with Bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation. / Waseda, Koichi; Tanimoto, Yasushi; Ichib, Shingo; Miyahara, Nobuaki; Murakami, Toshi; Ochi, Nobuaki; Terado, Michihisa; Nagano, Osamu; Maeda, Yoshinobu; Kanehiro, Arihiko; Ujike, Yoshihito; Tanimoto, Mitsune.

In: Acta Medica Okayama, Vol. 65, No. 6, 22.12.2011, p. 403-406.

Research output: Contribution to journalArticle

Waseda, K, Tanimoto, Y, Ichib, S, Miyahara, N, Murakami, T, Ochi, N, Terado, M, Nagano, O, Maeda, Y, Kanehiro, A, Ujike, Y & Tanimoto, M 2011, 'Successful extracorporeal life support for life-threatening hypercapnia with Bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation', Acta Medica Okayama, vol. 65, no. 6, pp. 403-406.
Waseda, Koichi ; Tanimoto, Yasushi ; Ichib, Shingo ; Miyahara, Nobuaki ; Murakami, Toshi ; Ochi, Nobuaki ; Terado, Michihisa ; Nagano, Osamu ; Maeda, Yoshinobu ; Kanehiro, Arihiko ; Ujike, Yoshihito ; Tanimoto, Mitsune. / Successful extracorporeal life support for life-threatening hypercapnia with Bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation. In: Acta Medica Okayama. 2011 ; Vol. 65, No. 6. pp. 403-406.
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