Successful chemotherapy for congenital malignant gliomas: A report of two cases

Takashi Tamiya, Soichiro Takao, Tomotsugu Ichikawa, Kosuke Chayama, Isao Date

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We describe the cases of 2 patients with a congenital malignant glioma that responded to chemotherapy. In the first case, a 2-month-old boy had a conjugate deviation to the right side and nystagmus. AT1-weighted gadolinium-enhanced magnetic resonance image showed a large tumor in his right frontal lobe. The tumor was partially resected, and the histological diagnosis was malignant ganglioglioma. The child then underwent 6 cycles of chemotherapy (mainly carboplatin and etoposide), and the residual tumor shrank. The tumor was then partially resected during a second operation, after which the patient underwent 5 cycles of chemotherapy (a combination of carboplatin, etoposide, vincristine, ifosfamide, cisplatin and cyclophosphamide). The tumor has not recurred in more than 8.5 years. In the second case, a 2-month-old boy had bulging of the anterior fontanel. The T1-weighted gadolinium-enhanced magnetic resonance image showed a large suprasellar tumor. The tumor was partially resected, and the histological diagnosis was anaplastic astrocytoma. The patient underwent 8 cycles of chemotherapy (MCNU, carboplatin and etoposide) and the tumor has not recurred in more than 7.5 years. Our experience indicates that, if surgical removal and chemotherapy are done aggressively for malignant gliomas in neonates and infants, long-term survival is possible.

Original languageEnglish
Pages (from-to)240-244
Number of pages5
JournalPediatric Neurosurgery
Volume42
Issue number4
DOIs
Publication statusPublished - May 1 2006

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Keywords

  • Anaplastic astrocytoma
  • Chemotherapy
  • Congenital glioma
  • Malignant ganglioglioma

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Surgery
  • Clinical Neurology

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