Successful chemotherapy for congenital malignant gliomas: A report of two cases

Takashi Tamiya, Soichiro Takao, Tomotsugu Ichikawa, Kosuke Chayama, Isao Date

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We describe the cases of 2 patients with a congenital malignant glioma that responded to chemotherapy. In the first case, a 2-month-old boy had a conjugate deviation to the right side and nystagmus. AT1-weighted gadolinium-enhanced magnetic resonance image showed a large tumor in his right frontal lobe. The tumor was partially resected, and the histological diagnosis was malignant ganglioglioma. The child then underwent 6 cycles of chemotherapy (mainly carboplatin and etoposide), and the residual tumor shrank. The tumor was then partially resected during a second operation, after which the patient underwent 5 cycles of chemotherapy (a combination of carboplatin, etoposide, vincristine, ifosfamide, cisplatin and cyclophosphamide). The tumor has not recurred in more than 8.5 years. In the second case, a 2-month-old boy had bulging of the anterior fontanel. The T1-weighted gadolinium-enhanced magnetic resonance image showed a large suprasellar tumor. The tumor was partially resected, and the histological diagnosis was anaplastic astrocytoma. The patient underwent 8 cycles of chemotherapy (MCNU, carboplatin and etoposide) and the tumor has not recurred in more than 7.5 years. Our experience indicates that, if surgical removal and chemotherapy are done aggressively for malignant gliomas in neonates and infants, long-term survival is possible.

Original languageEnglish
Pages (from-to)240-244
Number of pages5
JournalPediatric Neurosurgery
Volume42
Issue number4
DOIs
Publication statusPublished - May 2006

Fingerprint

Glioma
Drug Therapy
Carboplatin
Etoposide
Neoplasms
Gadolinium
Magnetic Resonance Spectroscopy
Cranial Fontanelles
Ganglioglioma
Ifosfamide
Astrocytoma
Residual Neoplasm
Frontal Lobe
Vincristine
Combination Drug Therapy
Cyclophosphamide
Cisplatin
Newborn Infant
Survival

Keywords

  • Anaplastic astrocytoma
  • Chemotherapy
  • Congenital glioma
  • Malignant ganglioglioma

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

Cite this

Successful chemotherapy for congenital malignant gliomas : A report of two cases. / Tamiya, Takashi; Takao, Soichiro; Ichikawa, Tomotsugu; Chayama, Kosuke; Date, Isao.

In: Pediatric Neurosurgery, Vol. 42, No. 4, 05.2006, p. 240-244.

Research output: Contribution to journalArticle

Tamiya, Takashi ; Takao, Soichiro ; Ichikawa, Tomotsugu ; Chayama, Kosuke ; Date, Isao. / Successful chemotherapy for congenital malignant gliomas : A report of two cases. In: Pediatric Neurosurgery. 2006 ; Vol. 42, No. 4. pp. 240-244.
@article{dda621dc3b8f429da96a7536cc5e333e,
title = "Successful chemotherapy for congenital malignant gliomas: A report of two cases",
abstract = "We describe the cases of 2 patients with a congenital malignant glioma that responded to chemotherapy. In the first case, a 2-month-old boy had a conjugate deviation to the right side and nystagmus. AT1-weighted gadolinium-enhanced magnetic resonance image showed a large tumor in his right frontal lobe. The tumor was partially resected, and the histological diagnosis was malignant ganglioglioma. The child then underwent 6 cycles of chemotherapy (mainly carboplatin and etoposide), and the residual tumor shrank. The tumor was then partially resected during a second operation, after which the patient underwent 5 cycles of chemotherapy (a combination of carboplatin, etoposide, vincristine, ifosfamide, cisplatin and cyclophosphamide). The tumor has not recurred in more than 8.5 years. In the second case, a 2-month-old boy had bulging of the anterior fontanel. The T1-weighted gadolinium-enhanced magnetic resonance image showed a large suprasellar tumor. The tumor was partially resected, and the histological diagnosis was anaplastic astrocytoma. The patient underwent 8 cycles of chemotherapy (MCNU, carboplatin and etoposide) and the tumor has not recurred in more than 7.5 years. Our experience indicates that, if surgical removal and chemotherapy are done aggressively for malignant gliomas in neonates and infants, long-term survival is possible.",
keywords = "Anaplastic astrocytoma, Chemotherapy, Congenital glioma, Malignant ganglioglioma",
author = "Takashi Tamiya and Soichiro Takao and Tomotsugu Ichikawa and Kosuke Chayama and Isao Date",
year = "2006",
month = "5",
doi = "10.1159/000092362",
language = "English",
volume = "42",
pages = "240--244",
journal = "Pediatric Neurosurgery",
issn = "1016-2291",
publisher = "S. Karger AG",
number = "4",

}

TY - JOUR

T1 - Successful chemotherapy for congenital malignant gliomas

T2 - A report of two cases

AU - Tamiya, Takashi

AU - Takao, Soichiro

AU - Ichikawa, Tomotsugu

AU - Chayama, Kosuke

AU - Date, Isao

PY - 2006/5

Y1 - 2006/5

N2 - We describe the cases of 2 patients with a congenital malignant glioma that responded to chemotherapy. In the first case, a 2-month-old boy had a conjugate deviation to the right side and nystagmus. AT1-weighted gadolinium-enhanced magnetic resonance image showed a large tumor in his right frontal lobe. The tumor was partially resected, and the histological diagnosis was malignant ganglioglioma. The child then underwent 6 cycles of chemotherapy (mainly carboplatin and etoposide), and the residual tumor shrank. The tumor was then partially resected during a second operation, after which the patient underwent 5 cycles of chemotherapy (a combination of carboplatin, etoposide, vincristine, ifosfamide, cisplatin and cyclophosphamide). The tumor has not recurred in more than 8.5 years. In the second case, a 2-month-old boy had bulging of the anterior fontanel. The T1-weighted gadolinium-enhanced magnetic resonance image showed a large suprasellar tumor. The tumor was partially resected, and the histological diagnosis was anaplastic astrocytoma. The patient underwent 8 cycles of chemotherapy (MCNU, carboplatin and etoposide) and the tumor has not recurred in more than 7.5 years. Our experience indicates that, if surgical removal and chemotherapy are done aggressively for malignant gliomas in neonates and infants, long-term survival is possible.

AB - We describe the cases of 2 patients with a congenital malignant glioma that responded to chemotherapy. In the first case, a 2-month-old boy had a conjugate deviation to the right side and nystagmus. AT1-weighted gadolinium-enhanced magnetic resonance image showed a large tumor in his right frontal lobe. The tumor was partially resected, and the histological diagnosis was malignant ganglioglioma. The child then underwent 6 cycles of chemotherapy (mainly carboplatin and etoposide), and the residual tumor shrank. The tumor was then partially resected during a second operation, after which the patient underwent 5 cycles of chemotherapy (a combination of carboplatin, etoposide, vincristine, ifosfamide, cisplatin and cyclophosphamide). The tumor has not recurred in more than 8.5 years. In the second case, a 2-month-old boy had bulging of the anterior fontanel. The T1-weighted gadolinium-enhanced magnetic resonance image showed a large suprasellar tumor. The tumor was partially resected, and the histological diagnosis was anaplastic astrocytoma. The patient underwent 8 cycles of chemotherapy (MCNU, carboplatin and etoposide) and the tumor has not recurred in more than 7.5 years. Our experience indicates that, if surgical removal and chemotherapy are done aggressively for malignant gliomas in neonates and infants, long-term survival is possible.

KW - Anaplastic astrocytoma

KW - Chemotherapy

KW - Congenital glioma

KW - Malignant ganglioglioma

UR - http://www.scopus.com/inward/record.url?scp=33646861765&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33646861765&partnerID=8YFLogxK

U2 - 10.1159/000092362

DO - 10.1159/000092362

M3 - Article

C2 - 16714866

AN - SCOPUS:33646861765

VL - 42

SP - 240

EP - 244

JO - Pediatric Neurosurgery

JF - Pediatric Neurosurgery

SN - 1016-2291

IS - 4

ER -