Success of Crizotinib Combined with Whole-Brain Radiotherapy for Brain Metastases in a Patient with Anaplastic Lymphoma Kinase Rearrangement-Positive Non-Small-Cell Lung Cancer

Sachi Okawa, Takuo Shibayama, Atsushi Shimonishi, Jun Nishimura, Taichi Ozeki, Kenji Takada, Hiroe Kayatani, Daisuke Minami, Ken Sato, Keiichi Fujiwara, Toshiro Yonei, Toshio Sato, Manabu Suno

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Although crizotinib shows marked antitumor activity in anaplastic lymphoma kinase (ALK) rearrangement-positive non-small-cell lung cancer (NSCLC) patients, all treated patients ultimately develop resistance to this drug. Isolated central nervous system failure without progression at extracranial sites is a common progression pattern in ALK rearrangement-positive NSCLC patients treated with crizotinib. Here, we report the success of crizotinib combined with whole-brain radiotherapy in an ALK rearrangement-positive NSCLC patient who developed leptomeningeal carcinomatosis and progression of multiple brain metastases. Additionally, we focused on the mechanism involved by examining the plasma and cerebrospinal fluid concentrations of crizotinib in the present case.

Original languageEnglish
Pages (from-to)777-783
Number of pages7
JournalCase Reports in Oncology
Volume11
Issue number3
DOIs
Publication statusPublished - Sep 1 2018

Keywords

  • ALK rearrangement-positive NSCLC
  • Blood-brain barrier permeability
  • Central nervous system failure
  • Crizotinib
  • Leptomeningeal carcinomatosis
  • Whole-brain radiotherapy

ASJC Scopus subject areas

  • Oncology

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    Okawa, S., Shibayama, T., Shimonishi, A., Nishimura, J., Ozeki, T., Takada, K., Kayatani, H., Minami, D., Sato, K., Fujiwara, K., Yonei, T., Sato, T., & Suno, M. (2018). Success of Crizotinib Combined with Whole-Brain Radiotherapy for Brain Metastases in a Patient with Anaplastic Lymphoma Kinase Rearrangement-Positive Non-Small-Cell Lung Cancer. Case Reports in Oncology, 11(3), 777-783. https://doi.org/10.1159/000492150