Substituent effect of 3,3,3-trifluoropropyl group on organic silanols. Palladium-mediated Mizoroki-Heck type and cross-coupling reactions

Kazunori Hirabayashi, Tatsuhiro Kondo, Fumihiko Toriyama, Yasushi Nishihara, Atsunori Mori

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The Mizoroki-Heck type reaction of methyl(phenyl)(3,3,3- trifluoropropyl)silanol (1a) with ethyl acrylate in the presence of Pd(OAc)2 (10 mol%) and Cu(OAc)2/LiOAc gave ethyl cinnamate in 70% yield. The palladium-catalyzed cross-coupling of 1a with 4-iodomethoxybenzene in the presence of Ag2O also afforded 4-methoxybiphenyl in 51% yield.

Original languageEnglish
Pages (from-to)749-750
Number of pages2
JournalBulletin of the Chemical Society of Japan
Issue number3
Publication statusPublished - Mar 2000
Externally publishedYes


ASJC Scopus subject areas

  • Chemistry(all)

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