Subconvulsive dose of strychnine enhances the transneuronal effect of peripheral sensory nerve transection

Tomosada Sugimoto, Motohide Takemura, Johji Okubo, Akira Sakai

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The effect of transection of the inferior alveolar nerve on the trigeminal subnucleus caudalis neuron was examined under the influence of systemic strychnine in the rat. Chronic intoxication with a subconvulsive dose of strychnine induced electron dense degeneration of somata and dendrites at 30 days following transection in the area of subnucleus caudalis which received primary projection from the transected nerve. Removal of the postsynaptic inhibition appears to enhance the transneuronal effect of peripheral nerve injury.

Original languageEnglish
Pages (from-to)320-325
Number of pages6
JournalBrain Research
Volume323
Issue number2
DOIs
Publication statusPublished - Dec 10 1984
Externally publishedYes

Fingerprint

Strychnine
Peripheral Nerves
Mandibular Nerve
Peripheral Nerve Injuries
Carisoprodol
Dendrites
Electrons
Neurons

Keywords

  • peripheral nerve injury
  • subnucleus caudalis
  • transneuronal degeneration
  • trigeminal nerve

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Subconvulsive dose of strychnine enhances the transneuronal effect of peripheral sensory nerve transection. / Sugimoto, Tomosada; Takemura, Motohide; Okubo, Johji; Sakai, Akira.

In: Brain Research, Vol. 323, No. 2, 10.12.1984, p. 320-325.

Research output: Contribution to journalArticle

Sugimoto, Tomosada ; Takemura, Motohide ; Okubo, Johji ; Sakai, Akira. / Subconvulsive dose of strychnine enhances the transneuronal effect of peripheral sensory nerve transection. In: Brain Research. 1984 ; Vol. 323, No. 2. pp. 320-325.
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