Styrene inhibits monoamine oxidase A, but not monoamine oxidase B in monkey brain mitochondria

Toru Egashira, Fusako Takayama, Kumiko Sakai, Yasumitsu Yamanaka

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The effects of styrene on mitochondrial monoamine oxidase (MAO) activity in rat and monkey brains were compared in vitro. After preincubation at 25°C for 20 min with 1 mM styrene monomer MAO-A activity in monkey brain was inhibited potently using 5-HT (for MAO-A substrate), but MAO-B activity in monkey brain and platelets were slightly inhibited using β-PEA (for MAO-B substrate). Styrene monomer also competitively inhibited MAO-A activity in a dose-dependent manner. MAO-A in monkey brain was inhibited by styrene in ascending order of potency: styrene trimer>styrene dimer>styrene monomer. In contrast styrene monomer slightly inhibited both MAO-A and MAO-B activities in rat brain mitochondria. In the present study styrene monomer potently inhibits MAO-A activity, but not MAO-B activity, in monkey brain mitochondria in vitro. These results indicate the inhibiting action of styrene differs depending on animal species and MAO isoforms. Copyright (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)115-119
Number of pages5
JournalToxicology Letters
Volume117
Issue number1-2
DOIs
Publication statusPublished - Sep 30 2000

Keywords

  • Mitochondrial monoamine oxidase-A
  • Mitochondrial monoamine oxidase-B
  • Monkey brain
  • Styrene

ASJC Scopus subject areas

  • Toxicology

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