Study on the anti-dementia therapies for rats with a unilateral basal forebrain lesion - Serial changes of the cholinergic markers' activities and event-related potentials after the administration of bifemelane hydrochloride or autotransplantation of the vagal nodosal ganglion

K. Ikeda, J. Yamashita, T. Egashira, Fusako Takayama, Y. Yamanaka

Research output: Contribution to journalArticle

Abstract

Using rats with a unilateral lesion in the nucleus basalis magnocellularis (NBM), we examined electrophysiologically the therapeutic effects of bifemelane (BIF) and autotransplantation of the vagal nodosal ganglion (X) on the event-related potential (P300) serially for 4 weeks, and also neurochemically their effects on cholinergic markers-the specific binding of 3H QNB (quinuclidinyl benzilate) on muscarinic acetyl-choline receptor (mAChR) and the activities of acetylcholinesterase (AChE) and choline acetyltransferase (CAT). The latency of P300 was continuously delayed and its amplitude remained low voltage until 4 weeks in the NBM-lesioned rats (No Tx group). Whereas the latency and amplitude returned to normal after 2-3 weeks in the rats given daily intraperitoneal injection of 15 mg/kg BIF (BIF group) and autotransplanted ones (X group). The cortical CAT and AChE levels on the lesion side did not recover until 4 weeks in No-Tx group, but the CAT levels recovered after 3 weeks in both BIF and X group; the AChE levels, after 1 week in BIF group and after 3 weeks in X group. The cortical mAChR on the lesion side was within or more than normal range in all rats. These results might indicate as follows: 1) Compensatory postsynaptic process such as cortical mAChR increase and AChE decrease occurred after acute cholinergic depletion. 2) Administration of BIF and X autotransplantation recovered cortical CAT and AChE levels and normalized cholinergic neuronal activity of P300.

Original languageEnglish
Pages (from-to)455-463
Number of pages9
JournalBrain and Nerve
Volume47
Issue number5
Publication statusPublished - 1995
Externally publishedYes

Fingerprint

Autologous Transplantation
Evoked Potentials
Ganglia
Cholinergic Agents
Dementia
Acetylcholinesterase
Choline O-Acetyltransferase
Choline
Basal Nucleus of Meynert
Therapeutics
Quinuclidinyl Benzilate
P300 Event-Related Potentials
Therapeutic Uses
Intraperitoneal Injections
bifemelane
Basal Forebrain
Reference Values

Keywords

  • bifemelane hydrochloride
  • cholinergic marker
  • event-related potential (P300)
  • nucleus basalis magnocellularis
  • vagal nodosal ganglion

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

@article{d9382aec21f64dc1a5389d0f23ca0f2e,
title = "Study on the anti-dementia therapies for rats with a unilateral basal forebrain lesion - Serial changes of the cholinergic markers' activities and event-related potentials after the administration of bifemelane hydrochloride or autotransplantation of the vagal nodosal ganglion",
abstract = "Using rats with a unilateral lesion in the nucleus basalis magnocellularis (NBM), we examined electrophysiologically the therapeutic effects of bifemelane (BIF) and autotransplantation of the vagal nodosal ganglion (X) on the event-related potential (P300) serially for 4 weeks, and also neurochemically their effects on cholinergic markers-the specific binding of 3H QNB (quinuclidinyl benzilate) on muscarinic acetyl-choline receptor (mAChR) and the activities of acetylcholinesterase (AChE) and choline acetyltransferase (CAT). The latency of P300 was continuously delayed and its amplitude remained low voltage until 4 weeks in the NBM-lesioned rats (No Tx group). Whereas the latency and amplitude returned to normal after 2-3 weeks in the rats given daily intraperitoneal injection of 15 mg/kg BIF (BIF group) and autotransplanted ones (X group). The cortical CAT and AChE levels on the lesion side did not recover until 4 weeks in No-Tx group, but the CAT levels recovered after 3 weeks in both BIF and X group; the AChE levels, after 1 week in BIF group and after 3 weeks in X group. The cortical mAChR on the lesion side was within or more than normal range in all rats. These results might indicate as follows: 1) Compensatory postsynaptic process such as cortical mAChR increase and AChE decrease occurred after acute cholinergic depletion. 2) Administration of BIF and X autotransplantation recovered cortical CAT and AChE levels and normalized cholinergic neuronal activity of P300.",
keywords = "bifemelane hydrochloride, cholinergic marker, event-related potential (P300), nucleus basalis magnocellularis, vagal nodosal ganglion",
author = "K. Ikeda and J. Yamashita and T. Egashira and Fusako Takayama and Y. Yamanaka",
year = "1995",
language = "English",
volume = "47",
pages = "455--463",
journal = "Brain and Nerve",
issn = "0006-8969",
publisher = "Igaku-Shoin Ltd",
number = "5",

}

TY - JOUR

T1 - Study on the anti-dementia therapies for rats with a unilateral basal forebrain lesion - Serial changes of the cholinergic markers' activities and event-related potentials after the administration of bifemelane hydrochloride or autotransplantation of the vagal nodosal ganglion

AU - Ikeda, K.

AU - Yamashita, J.

AU - Egashira, T.

AU - Takayama, Fusako

AU - Yamanaka, Y.

PY - 1995

Y1 - 1995

N2 - Using rats with a unilateral lesion in the nucleus basalis magnocellularis (NBM), we examined electrophysiologically the therapeutic effects of bifemelane (BIF) and autotransplantation of the vagal nodosal ganglion (X) on the event-related potential (P300) serially for 4 weeks, and also neurochemically their effects on cholinergic markers-the specific binding of 3H QNB (quinuclidinyl benzilate) on muscarinic acetyl-choline receptor (mAChR) and the activities of acetylcholinesterase (AChE) and choline acetyltransferase (CAT). The latency of P300 was continuously delayed and its amplitude remained low voltage until 4 weeks in the NBM-lesioned rats (No Tx group). Whereas the latency and amplitude returned to normal after 2-3 weeks in the rats given daily intraperitoneal injection of 15 mg/kg BIF (BIF group) and autotransplanted ones (X group). The cortical CAT and AChE levels on the lesion side did not recover until 4 weeks in No-Tx group, but the CAT levels recovered after 3 weeks in both BIF and X group; the AChE levels, after 1 week in BIF group and after 3 weeks in X group. The cortical mAChR on the lesion side was within or more than normal range in all rats. These results might indicate as follows: 1) Compensatory postsynaptic process such as cortical mAChR increase and AChE decrease occurred after acute cholinergic depletion. 2) Administration of BIF and X autotransplantation recovered cortical CAT and AChE levels and normalized cholinergic neuronal activity of P300.

AB - Using rats with a unilateral lesion in the nucleus basalis magnocellularis (NBM), we examined electrophysiologically the therapeutic effects of bifemelane (BIF) and autotransplantation of the vagal nodosal ganglion (X) on the event-related potential (P300) serially for 4 weeks, and also neurochemically their effects on cholinergic markers-the specific binding of 3H QNB (quinuclidinyl benzilate) on muscarinic acetyl-choline receptor (mAChR) and the activities of acetylcholinesterase (AChE) and choline acetyltransferase (CAT). The latency of P300 was continuously delayed and its amplitude remained low voltage until 4 weeks in the NBM-lesioned rats (No Tx group). Whereas the latency and amplitude returned to normal after 2-3 weeks in the rats given daily intraperitoneal injection of 15 mg/kg BIF (BIF group) and autotransplanted ones (X group). The cortical CAT and AChE levels on the lesion side did not recover until 4 weeks in No-Tx group, but the CAT levels recovered after 3 weeks in both BIF and X group; the AChE levels, after 1 week in BIF group and after 3 weeks in X group. The cortical mAChR on the lesion side was within or more than normal range in all rats. These results might indicate as follows: 1) Compensatory postsynaptic process such as cortical mAChR increase and AChE decrease occurred after acute cholinergic depletion. 2) Administration of BIF and X autotransplantation recovered cortical CAT and AChE levels and normalized cholinergic neuronal activity of P300.

KW - bifemelane hydrochloride

KW - cholinergic marker

KW - event-related potential (P300)

KW - nucleus basalis magnocellularis

KW - vagal nodosal ganglion

UR - http://www.scopus.com/inward/record.url?scp=0029048646&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029048646&partnerID=8YFLogxK

M3 - Article

C2 - 7786622

AN - SCOPUS:0029048646

VL - 47

SP - 455

EP - 463

JO - Brain and Nerve

JF - Brain and Nerve

SN - 0006-8969

IS - 5

ER -