Study on the anti-dementia therapies for rats with a unilateral basal forebrain lesion - Serial changes of the cholinergic markers' activities and event-related potentials after the administration of bifemelane hydrochloride or autotransplantation of the vagal nodosal ganglion

K. Ikeda, J. Yamashita, T. Egashira, F. Takayama, Y. Yamanaka

Research output: Contribution to journalArticle

Abstract

Using rats with a unilateral lesion in the nucleus basalis magnocellularis (NBM), we examined electrophysiologically the therapeutic effects of bifemelane (BIF) and autotransplantation of the vagal nodosal ganglion (X) on the event-related potential (P300) serially for 4 weeks, and also neurochemically their effects on cholinergic markers-the specific binding of 3H QNB (quinuclidinyl benzilate) on muscarinic acetyl-choline receptor (mAChR) and the activities of acetylcholinesterase (AChE) and choline acetyltransferase (CAT). The latency of P300 was continuously delayed and its amplitude remained low voltage until 4 weeks in the NBM-lesioned rats (No Tx group). Whereas the latency and amplitude returned to normal after 2-3 weeks in the rats given daily intraperitoneal injection of 15 mg/kg BIF (BIF group) and autotransplanted ones (X group). The cortical CAT and AChE levels on the lesion side did not recover until 4 weeks in No-Tx group, but the CAT levels recovered after 3 weeks in both BIF and X group; the AChE levels, after 1 week in BIF group and after 3 weeks in X group. The cortical mAChR on the lesion side was within or more than normal range in all rats. These results might indicate as follows: 1) Compensatory postsynaptic process such as cortical mAChR increase and AChE decrease occurred after acute cholinergic depletion. 2) Administration of BIF and X autotransplantation recovered cortical CAT and AChE levels and normalized cholinergic neuronal activity of P300.

Original languageEnglish
Pages (from-to)455-463
Number of pages9
JournalBrain and Nerve
Volume47
Issue number5
Publication statusPublished - Jan 1 1995
Externally publishedYes

Keywords

  • bifemelane hydrochloride
  • cholinergic marker
  • event-related potential (P300)
  • nucleus basalis magnocellularis
  • vagal nodosal ganglion

ASJC Scopus subject areas

  • Neuroscience(all)

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