Study on Biologic Effects of Radon and Thermal Therapy on Osteoarthritis

Kiyonori Yamaoka, Fumihiro Mitsunobu, Katsumi Hanamoto, Shuji Mori, Yoshiro Tanizaki, Katsuhiko Sugita

Research output: Contribution to journalArticlepeer-review

57 Citations (Scopus)


Radon therapy uses radon (222Rn) gas, which mainly emits α-rays and induces a small amount of active oxygen in the body. We first examined the temporal changes in antioxidants, immune, vasoactive, and pain-associated substances in human blood by therapy to elucidate the mechanism of osteoarthritis in which radon therapy is used as a treatment. Results showed that radon inhalation enhanced the antioxidation and immune function, and the findings suggest that radon therapy contributes to the prevention of osteoarthritis related to peroxidation reactions and immune depression. Moreover, the changes in vasoactive and pain-associated substances indicated increases in tissue perfusion brought about by radon therapy, suggesting that radon inhalation plays a role in alleviating pain. Perspective: The findings suggest that an appropriate amount of active oxygen is produced in the body after radon inhalation, and this contributes to the alleviation of the symptoms of active oxygen diseases such as osteoarthritis.

Original languageEnglish
Pages (from-to)20-25
Number of pages6
JournalJournal of Pain
Issue number1
Publication statusPublished - Feb 2004


  • Antioxidants
  • Osteoarthritis
  • Pain-associated substance
  • Radon therapy
  • Vasoactive substance

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Anesthesiology and Pain Medicine


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