Study of the response of superoxide dismutase in mouse organsto radon using a new large-scale facility forex posing small animals to radon

Takahiro Kataoka, Akihiro Sakoda, Yuu Ishimori, Teruaki Toyota, Yuichi Nishiyama, Hiroshi Tanaka, Fumihiro Mitsunobu, Kiyonori Yamaoka

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19 Citations (Scopus)

Abstract

We examined dose-dependent or dose rate-dependent changes of superoxide dismutase (SOD) activity using a new large-scale facility for exposing small animals to radon. Mice were exposed to radon at a concentration of 250, 500, 1000, 2000, or 4000 Bq/m 3 for 0.5, 1, 2, 4, or 8 days. When mice were exposed to radon at 2000 day•Bq/m 3, activation of SOD activities in plasma, liver, pancreas, heart, thymus, and kidney showed dose-rate effects. Our results also suggested that continuous exposure to radon increased SOD activity, but SOD activity transiently returned to normal levels at around 2 days. Moreover, we classified the organs into four groups (1. plasma, brain, lung; 2. heart, liver, pancreas, small intestine; 3. kidney, thymus; 4. stomach) based on changes in SOD activity. Thymus had the highest responsiveness and stomach had lowest. These data provide useful baseline measurements for future studies on radon effects.

Original languageEnglish
Pages (from-to)775-781
Number of pages7
JournalJournal of Radiation Research
Volume52
Issue number6
DOIs
Publication statusPublished - Nov 2011

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Keywords

  • Dose
  • Dose rate
  • Large-scale facility
  • Radon
  • Superoxide dismutase

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiation
  • Health, Toxicology and Mutagenesis

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