Study of Amelogenin Gene Expression in Ameloblastoma

Hidetsugu Tsujigiwa; Hitoshi Nagatsuka; Mehmet Gunduz; Masao Yamada; Noriyuki Nagai; Shin Hong-In; Satoshi Ichihara

doi:10.2485/jhtb.14.192

Study of Amelogenin Gene Expression in Ameloblastoma

Hidetsugu Tsujigiwa, Hitoshi Nagatsuka, Mehmet Gunduz, Masao Yamada, Noriyuki Nagai, Shin Hong-In, Satoshi Ichihara

Research output: Contribution to journal › Article

Abstract

Although it has been known that amelogenin gene is expressed in ameloblastoma, the precise expression pattem of X and Y amelogenin genes (AMGX, AMGY) in this tumor has not yet identified. In this study, we analyzed amelogenin gene expression in 19 samples (9 male, 10 female) of oral ameloblastomas by RT-PCR and detect the chromosomal origin of amelogenin mRNA by restriction enzyme digestion of the RT-PCR product. All tumor samples expressed amelogenin mRNA. We could detect increased level of AMGY expression in all male samples, higher than that of AMEX. It is an interesting finding as in normal male tooth development, the expression of AMGY is very much lower than that of AMGX. We postulate that epigenetic change of sex chromosomes may have some correlations with tumorigenesis of ameloblastoma. We also discuss the other possible mechanisms and points for future studies on this the change in expression pattern.

Original language	English
Pages (from-to)	192-193
Number of pages	2
Journal	Journal of Hard Tissue Biology
Volume	14
Issue number	2
DOIs	https://doi.org/10.2485/jhtb.14.192
Publication status	Published - 2005

ASJC Scopus subject areas

Medicine (miscellaneous)
Biochemistry
Biomaterials
Orthopedics and Sports Medicine
Dentistry(all)
Cell Biology

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Tsujigiwa, H., Nagatsuka, H., Gunduz, M., Yamada, M., Nagai, N., Hong-In, S., & Ichihara, S. (2005). Study of Amelogenin Gene Expression in Ameloblastoma. Journal of Hard Tissue Biology, 14(2), 192-193. https://doi.org/10.2485/jhtb.14.192

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author = "Hidetsugu Tsujigiwa and Hitoshi Nagatsuka and Mehmet Gunduz and Masao Yamada and Noriyuki Nagai and Shin Hong-In and Satoshi Ichihara",

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AU - Tsujigiwa, Hidetsugu

AU - Nagatsuka, Hitoshi

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AU - Nagai, Noriyuki

AU - Hong-In, Shin

AU - Ichihara, Satoshi

PY - 2005

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