The Multi-Pixel Photon Counter (MPPC) is a novel semiconductor photon sensor belonging to the Pixelated Photon Detector (PPD) family, which also includes the Silicon-Photomultiplier . Since it has many remarkable features, we are studying and developing the MPPC, aiming to utilize it to read out a strip-scintillator calorimeter for a future linear collider experiment. We have measured the gain and photon detection efficiency of the 1600 pixel MPPC, which are comparable to the performance of conventional photomultipliers, and its dark noise rate and cross-talk, which are acceptably small. The dynamic range, a weak point of the MPPC, is confirmed to be enhanced thanks to a short recovery time. After ensuring the acceptable performance of 1600 pixel MPPCs, we built a calorimeter test module with a scintillator-strip structure and full MPPC readout, and exposed it to positron beams to evaluate its performance. Results of the beam test show good performance of the calorimeter prototype. These results indicate that the MPPC is a promising device not only for calorimeter readout, but also for photon detection in various other fields.