Study about the efficacy of metformin to immune function in cancer patients

Mototsugu Watanabe; Hiromasa Yamamoto; Shingo Eikawa; Kazuhiko Shien; Tadahiko Shien; Junichi Soh; Katsuyuki Hotta; Jun Wada; Shiro Hinotsu; Toshiyoshi Fujiwara; Katsuyuki Kiura; Hiroyoshi Doihara; Shinichiro Miyoshi; Heiichiro Udono; Shinichi Toyooka

Study about the efficacy of metformin to immune function in cancer patients

Mototsugu Watanabe, Hiromasa Yamamoto, Shingo Eikawa, Kazuhiko Shien, Tadahiko Shien, Junichi Soh, Katsuyuki Hotta, Jun Wada, Shiro Hinotsu, Toshiyoshi Fujiwara, Katsuyuki Kiura, Hiroyoshi Doihara, Shinichiro Miyoshi, Heiichiro Udono, Shinichi Toyooka

Research output: Contribution to journal › Article

2 Citations (Scopus)

Abstract

A study to evaluate the effect of metformin on the immune system was commenced in July 2014. Metformin is one of the most commonly prescribed drugs for type 2 diabetes, and previous studies have reported that metformin has an anti-tumor effect. The aim of this study is to evaluate the efficacy of metformin on the immune system in human cancer patients in vivo. The primary outcome parameter will be the rate change in the population of CD8⁺ T cells, which produce multiple cytokines.

Original language	English
Pages (from-to)	327-330
Number of pages	4
Journal	Acta medica Okayama
Volume	70
Issue number	4
Publication status	Published - 2016

Keywords

CD8 T cells
Cancer immunology
Metformin

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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Watanabe, M., Yamamoto, H., Eikawa, S., Shien, K., Shien, T., Soh, J., Hotta, K., Wada, J., Hinotsu, S., Fujiwara, T., Kiura, K., Doihara, H., Miyoshi, S., Udono, H., & Toyooka, S. (2016). Study about the efficacy of metformin to immune function in cancer patients. Acta medica Okayama, 70(4), 327-330.

Study about the efficacy of metformin to immune function in cancer patients. / Watanabe, Mototsugu; Yamamoto, Hiromasa; Eikawa, Shingo; Shien, Kazuhiko; Shien, Tadahiko; Soh, Junichi; Hotta, Katsuyuki ; Wada, Jun; Hinotsu, Shiro; Fujiwara, Toshiyoshi ; Kiura, Katsuyuki ; Doihara, Hiroyoshi; Miyoshi, Shinichiro; Udono, Heiichiro ; Toyooka, Shinichi.

In: Acta medica Okayama, Vol. 70, No. 4, 2016, p. 327-330.

Research output: Contribution to journal › Article

Watanabe, Mototsugu ; Yamamoto, Hiromasa ; Eikawa, Shingo ; Shien, Kazuhiko ; Shien, Tadahiko ; Soh, Junichi ; Hotta, Katsuyuki ; Wada, Jun ; Hinotsu, Shiro ; Fujiwara, Toshiyoshi ; Kiura, Katsuyuki ; Doihara, Hiroyoshi ; Miyoshi, Shinichiro ; Udono, Heiichiro ; Toyooka, Shinichi. / Study about the efficacy of metformin to immune function in cancer patients. In: Acta medica Okayama. 2016 ; Vol. 70, No. 4. pp. 327-330.

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