Study about the efficacy of metformin to immune function in cancer patients

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A study to evaluate the effect of metformin on the immune system was commenced in July 2014. Metformin is one of the most commonly prescribed drugs for type 2 diabetes, and previous studies have reported that metformin has an anti-tumor effect. The aim of this study is to evaluate the efficacy of metformin on the immune system in human cancer patients in vivo. The primary outcome parameter will be the rate change in the population of CD8+ T cells, which produce multiple cytokines.

Original languageEnglish
Pages (from-to)327-330
Number of pages4
JournalActa Medica Okayama
Volume70
Issue number4
Publication statusPublished - 2016

Fingerprint

Metformin
Immune system
Immune System
Neoplasms
T-cells
Medical problems
Type 2 Diabetes Mellitus
Tumors
Cytokines
T-Lymphocytes
Pharmaceutical Preparations
Population

Keywords

  • Cancer immunology
  • CD8 T cells
  • Metformin

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

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title = "Study about the efficacy of metformin to immune function in cancer patients",
abstract = "A study to evaluate the effect of metformin on the immune system was commenced in July 2014. Metformin is one of the most commonly prescribed drugs for type 2 diabetes, and previous studies have reported that metformin has an anti-tumor effect. The aim of this study is to evaluate the efficacy of metformin on the immune system in human cancer patients in vivo. The primary outcome parameter will be the rate change in the population of CD8+ T cells, which produce multiple cytokines.",
keywords = "Cancer immunology, CD8 T cells, Metformin",
author = "Mototsugu Watanabe and Hiromasa Yamamoto and Shingo Eikawa and Kazuhiko Shien and Tadahiko Shien and Junichi Sou and Katsuyuki Hotta and Jun Wada and Shiro Hinotsu and Toshiyoshi Fujiwara and Katsuyuki Kiura and Hiroyoshi Doihara and Shinichiro Miyoshi and Heiichiro Udono and Shinichi Toyooka",
year = "2016",
language = "English",
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pages = "327--330",
journal = "Acta Medica Okayama",
issn = "0386-300X",
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T1 - Study about the efficacy of metformin to immune function in cancer patients

AU - Watanabe, Mototsugu

AU - Yamamoto, Hiromasa

AU - Eikawa, Shingo

AU - Shien, Kazuhiko

AU - Shien, Tadahiko

AU - Sou, Junichi

AU - Hotta, Katsuyuki

AU - Wada, Jun

AU - Hinotsu, Shiro

AU - Fujiwara, Toshiyoshi

AU - Kiura, Katsuyuki

AU - Doihara, Hiroyoshi

AU - Miyoshi, Shinichiro

AU - Udono, Heiichiro

AU - Toyooka, Shinichi

PY - 2016

Y1 - 2016

N2 - A study to evaluate the effect of metformin on the immune system was commenced in July 2014. Metformin is one of the most commonly prescribed drugs for type 2 diabetes, and previous studies have reported that metformin has an anti-tumor effect. The aim of this study is to evaluate the efficacy of metformin on the immune system in human cancer patients in vivo. The primary outcome parameter will be the rate change in the population of CD8+ T cells, which produce multiple cytokines.

AB - A study to evaluate the effect of metformin on the immune system was commenced in July 2014. Metformin is one of the most commonly prescribed drugs for type 2 diabetes, and previous studies have reported that metformin has an anti-tumor effect. The aim of this study is to evaluate the efficacy of metformin on the immune system in human cancer patients in vivo. The primary outcome parameter will be the rate change in the population of CD8+ T cells, which produce multiple cytokines.

KW - Cancer immunology

KW - CD8 T cells

KW - Metformin

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