Study about the efficacy of metformin to immune function in cancer patients

Mototsugu Watanabe; Hiromasa Yamamoto; Shingo Eikawa; Kazuhiko Shien; Tadahiko Shien; Junichi Sou; Katsuyuki Hotta; Jun Wada; shiro Hinotsu; Toshiyoshi Fujiwara; Katsuyuki Kiura; Hiroyoshi Doihara; Shinichiro Miyoshi; Heiichiro Udono; Shinichi Toyooka

Study about the efficacy of metformin to immune function in cancer patients

Mototsugu Watanabe, Hiromasa Yamamoto, Shingo Eikawa, Kazuhiko Shien, Tadahiko Shien, Junichi Sou, Katsuyuki Hotta, Jun Wada, shiro Hinotsu, Toshiyoshi Fujiwara, Katsuyuki Kiura, Hiroyoshi Doihara, Shinichiro Miyoshi, Heiichiro Udono, Shinichi Toyooka

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

A study to evaluate the effect of metformin on the immune system was commenced in July 2014. Metformin is one of the most commonly prescribed drugs for type 2 diabetes, and previous studies have reported that metformin has an anti-tumor effect. The aim of this study is to evaluate the efficacy of metformin on the immune system in human cancer patients in vivo. The primary outcome parameter will be the rate change in the population of CD8⁺ T cells, which produce multiple cytokines.

Original language	English
Pages (from-to)	327-330
Number of pages	4
Journal	Acta medica Okayama
Volume	70
Issue number	4
Publication status	Published - 2016

Keywords

CD8 T cells
Cancer immunology
Metformin

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

@article{b7d65c26c94d4388912d2a078a79fca6,

title = "Study about the efficacy of metformin to immune function in cancer patients",

abstract = "A study to evaluate the effect of metformin on the immune system was commenced in July 2014. Metformin is one of the most commonly prescribed drugs for type 2 diabetes, and previous studies have reported that metformin has an anti-tumor effect. The aim of this study is to evaluate the efficacy of metformin on the immune system in human cancer patients in vivo. The primary outcome parameter will be the rate change in the population of CD8+ T cells, which produce multiple cytokines.",

keywords = "CD8 T cells, Cancer immunology, Metformin",

author = "Mototsugu Watanabe and Hiromasa Yamamoto and Shingo Eikawa and Kazuhiko Shien and Tadahiko Shien and Junichi Sou and Katsuyuki Hotta and Jun Wada and shiro Hinotsu and Toshiyoshi Fujiwara and Katsuyuki Kiura and Hiroyoshi Doihara and Shinichiro Miyoshi and Heiichiro Udono and Shinichi Toyooka",

note = "Funding Information: This work was supported by JSPS KAKENHI Grant Number JP16K15637. Publisher Copyright: {\textcopyright} 2016 by Okayama University Medical School.",

year = "2016",

language = "English",

volume = "70",

pages = "327--330",

journal = "Acta Medica Okayama",

issn = "0386-300X",

publisher = "Okayama University",

number = "4",

}

TY - JOUR

T1 - Study about the efficacy of metformin to immune function in cancer patients

AU - Watanabe, Mototsugu

AU - Yamamoto, Hiromasa

AU - Eikawa, Shingo

AU - Shien, Kazuhiko

AU - Shien, Tadahiko

AU - Sou, Junichi

AU - Hotta, Katsuyuki

AU - Wada, Jun

AU - Hinotsu, shiro

AU - Fujiwara, Toshiyoshi

AU - Kiura, Katsuyuki

AU - Doihara, Hiroyoshi

AU - Miyoshi, Shinichiro

AU - Udono, Heiichiro

AU - Toyooka, Shinichi

PY - 2016

Y1 - 2016

N2 - A study to evaluate the effect of metformin on the immune system was commenced in July 2014. Metformin is one of the most commonly prescribed drugs for type 2 diabetes, and previous studies have reported that metformin has an anti-tumor effect. The aim of this study is to evaluate the efficacy of metformin on the immune system in human cancer patients in vivo. The primary outcome parameter will be the rate change in the population of CD8+ T cells, which produce multiple cytokines.

AB - A study to evaluate the effect of metformin on the immune system was commenced in July 2014. Metformin is one of the most commonly prescribed drugs for type 2 diabetes, and previous studies have reported that metformin has an anti-tumor effect. The aim of this study is to evaluate the efficacy of metformin on the immune system in human cancer patients in vivo. The primary outcome parameter will be the rate change in the population of CD8+ T cells, which produce multiple cytokines.

KW - CD8 T cells

KW - Cancer immunology

KW - Metformin

UR - http://www.scopus.com/inward/record.url?scp=84984848485&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84984848485&partnerID=8YFLogxK

M3 - Article

C2 - 27549683

AN - SCOPUS:84984848485

VL - 70

SP - 327

EP - 330

JO - Acta Medica Okayama

JF - Acta Medica Okayama

SN - 0386-300X

IS - 4

ER -

Study about the efficacy of metformin to immune function in cancer patients

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Other files and links

Fingerprint

Cite this