Studies toward the synthesis of toddquinoline by intramolecular cyclization

Georgeta Serban, Yasumi Shigeta, Hiromi Nishioka, Hitoshi Abe, Yasuo Takeuchi, Takashi Harayamac

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


In connection with studies on the total synthesis of toddaquinoline (1), the synthesis of [1,3]dioxolo[4',5':4,5]benzo[h]quinoline (la), which is the tetracyclic core of 1, was investigated. Intramolecular benzene-pyridine coupling reactions of the monobromide (9) and dibromide (10), using a Pd reagent and Cu reagent, were evaluated to produce la in poor to moderate yields.

Original languageEnglish
Pages (from-to)1623-1630
Number of pages8
Issue number7
Publication statusPublished - Jul 1 2007


  • Aryl-Aryl Coupling Reaction
  • Benzo[h]quinoline Alkaloid
  • Parladium-Assisted Reaction
  • Toddalia asiatica
  • Ullmann Reaction

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry


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