Abstract
Alkoxyl radicals have a wide range of applications in organic synthesis due to their remarkable chemical properties in molecular transformation. The present study shows two types of alkoxyl radicals (primary vs tertiary) to selectively undergo dehydrogenation and β-scission to give rise to key structural elements of (-)-CP-263,114 (1). By alkoxyl radical transformation followed by installation of the C19-C25 (CP numbering) side chain and the bridged bisacetal unit, the functionalized CP precursor 2 was obtained.
Original language | English |
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Pages (from-to) | 9262-9268 |
Number of pages | 7 |
Journal | Journal of Organic Chemistry |
Volume | 69 |
Issue number | 26 |
DOIs | |
Publication status | Published - Dec 24 2004 |
Externally published | Yes |
ASJC Scopus subject areas
- Organic Chemistry