Studies on the total synthesis of (-)-CP-263,114

Takehiko Yoshimitsu, Shuji Sasaki, Yoshimasa Arano, Hiroto Nagaoka

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21 Citations (Scopus)

Abstract

Alkoxyl radicals have a wide range of applications in organic synthesis due to their remarkable chemical properties in molecular transformation. The present study shows two types of alkoxyl radicals (primary vs tertiary) to selectively undergo dehydrogenation and β-scission to give rise to key structural elements of (-)-CP-263,114 (1). By alkoxyl radical transformation followed by installation of the C19-C25 (CP numbering) side chain and the bridged bisacetal unit, the functionalized CP precursor 2 was obtained.

Original languageEnglish
Pages (from-to)9262-9268
Number of pages7
JournalJournal of Organic Chemistry
Volume69
Issue number26
DOIs
Publication statusPublished - Dec 24 2004

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ASJC Scopus subject areas

  • Organic Chemistry

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