Studies on the sleep-inducing effect of diphenhydramine hydrochloride

C. Kamei, K. Saito, Yukio Sugimoto, Z. Chen, Q. Zhao

Research output: Contribution to journalArticle

Abstract

The present study was undertaken to clarify whether or not diphenhydramine is useful for sedative-hypnotic drug. EEG power spectra of delta band (0-4Hz) at the frontal cortex in rats was used for an index of sleep. Diphenhydramine at doses of 2-20mg/kg, p.o. caused a dose-dependent shortening of sleep latency and prolongation of sleep duration. Significant effect was observed at a dose of 10 mg/kg or more. These effects were almost the same as those of chlorpheniramine and less than those of brotizolam. The results clearly indicate that diphenhydramine is effective sedative-hypnotic drug for mild insomnia.

Original languageEnglish
Pages (from-to)15-19
Number of pages5
JournalJapanese Pharmacology and Therapeutics
Volume27
Issue number5
Publication statusPublished - 1999

Fingerprint

Diphenhydramine
Sleep
brotizolam
Hypnotics and Sedatives
Chlorpheniramine
Sleep Initiation and Maintenance Disorders
Frontal Lobe
Pharmaceutical Preparations
Electroencephalography

Keywords

  • Diphenhydramine
  • EEG power spectra
  • Sleep

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology

Cite this

Studies on the sleep-inducing effect of diphenhydramine hydrochloride. / Kamei, C.; Saito, K.; Sugimoto, Yukio; Chen, Z.; Zhao, Q.

In: Japanese Pharmacology and Therapeutics, Vol. 27, No. 5, 1999, p. 15-19.

Research output: Contribution to journalArticle

Kamei, C. ; Saito, K. ; Sugimoto, Yukio ; Chen, Z. ; Zhao, Q. / Studies on the sleep-inducing effect of diphenhydramine hydrochloride. In: Japanese Pharmacology and Therapeutics. 1999 ; Vol. 27, No. 5. pp. 15-19.
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