The method using single photon emission computed tomography (SPECT) for measurement of the hepatosplenic volume and the accumulation rate of 99mTc Sn colloid was studied, and applied to patients with liver cirrhosis. The hepatosplenic volume calculated by this method was well correlated with that by computed tomography (r=0.938). The accumulation rate obtained by this method was almost equal to that by whole body scintigraphy. In liver cirrohsis (Child B and C group) the liver volume was atrophic and the splenic volume hypertrophic. The liver accumulation rate was decreased corresponding with the degree of liver cirrohsis, but the accumulation rate per volume was decreased in Child B and C. The splenic accumulation rate was increased in Child B and C, but the accumulation rate per volume was not significant between control group and liver cirrohsis. The measurement of the hepatosplenic volume and accumulation rate by SPECT is useful to evaluate the hepatosplenic function.
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